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Source: The Lancet Neurology
Condition: Stroke

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Total 244 results found since Jan 2013.

Diagnosis of atrial fibrillation after stroke and transient ischaemic attack: a systematic review and meta-analysis
Publication date: Available online 4 March 2015 Source:The Lancet Neurology Author(s): Luciano A Sposato , Lauren E Cipriano , Gustavo Saposnik , Estefanía Ruíz Vargas , Patricia M Riccio , Vladimir Hachinski Background Among patients with atrial fibrillation, the risk of stroke is highest for those with a history of stroke; however, oral anticoagulants can lower the risk of recurrent stroke by two-thirds. No consensus has been reached about how atrial fibrillation should be investigated in patients with stroke, and its prevalence after a stroke remains uncertain. We did a systematic review and meta-analysis to estimat...
Source: The Lancet Neurology - March 5, 2015 Category: Neurology Source Type: research

Alteplase versus tenecteplase for thrombolysis after ischaemic stroke (ATTEST): a phase 2, randomised, open-label, blinded endpoint study
This study is registered with ClinicalTrials.gov, number NCT01472926. Findings Between Jan 1, 2012, and Sept 7, 2013, 355 patients were screened, of whom 157 were eligible for intravenous thrombolysis, and 104 patients were enrolled. 52 were assigned to the alteplase group and 52 to tenecteplase. Of 71 patients (35 assigned tenecteplase and 36 assigned alteplase) contributing to the primary endpoint, no significant differences were noted for percentage of penumbral salvaged (68% [SD 28] for the tenecteplase group vs 68% [23] for the alteplase group; mean difference 1·3% [95% CI −9·6 to 12·1]; p=0·81). Neither incide...
Source: The Lancet Neurology - February 26, 2015 Category: Neurology Source Type: research

Breaking up is hard to do: tenecteplase in acute stroke
Publication date: Available online 26 February 2015 Source:The Lancet Neurology Author(s): Lee H Schwamm
Source: The Lancet Neurology - February 26, 2015 Category: Neurology Source Type: research

Antiplatelet treatment compared with anticoagulation treatment for cervical artery dissection (CADISS): a randomised trial
Publication date: Available online 12 February 2015 Source:The Lancet Neurology Background Extracranial carotid and vertebral artery dissection is an important cause of stroke, especially in young people. In some observational studies it has been associated with a high risk of recurrent stroke. Both antiplatelet drugs and anticoagulant drugs are used to reduce risk of stroke but whether one treatment strategy is more effective than the other is unknown. We compared their efficacy in the Cervical Artery Dissection in Stroke Study (CADISS), with the additional aim of establishing the true risk of recurrent stroke. Methods W...
Source: The Lancet Neurology - February 13, 2015 Category: Neurology Source Type: research

Constraint-induced movement therapy after stroke
Publication date: February 2015 Source:The Lancet Neurology, Volume 14, Issue 2 Author(s): Gert Kwakkel , Janne M Veerbeek , Erwin E H van Wegen , Steven L Wolf Constraint-induced movement therapy (CIMT) was developed to overcome upper limb impairments after stroke and is the most investigated intervention for the rehabilitation of patients. Original CIMT includes constraining of the non-paretic arm and task-oriented training. Modified versions also apply constraining of the non-paretic arm, but not as intensive as original CIMT. Behavioural strategies are mostly absent for both modified and original CIMT. With forced us...
Source: The Lancet Neurology - January 12, 2015 Category: Neurology Source Type: research

Stroke: an emphasis on guidelines
Publication date: January 2015 Source:The Lancet Neurology, Volume 14, Issue 1 Author(s): Philip B Gorelick , Muhammad U Farooq
Source: The Lancet Neurology - December 9, 2014 Category: Neurology Source Type: research

Migraine pathophysiology: lessons from mouse models and human genetics
Publication date: January 2015 Source:The Lancet Neurology, Volume 14, Issue 1 Author(s): Michel D Ferrari , Roselin R Klever , Gisela M Terwindt , Cenk Ayata , Arn M J M van den Maagdenberg Summary Migraine is a common, disabling, and undertreated episodic brain disorder that is more common in women than in men. Unbiased genome-wide association studies have identified 13 migraine-associated variants pointing at genes that cluster in pathways for glutamatergic neurotransmission, synaptic function, pain sensing, metalloproteinases, and the vasculature. The individual pathogenetic contribution of each gene variant is diffi...
Source: The Lancet Neurology - December 9, 2014 Category: Neurology Source Type: research

Paediatric stroke: pressing issues and promising directions
Publication date: January 2015 Source:The Lancet Neurology, Volume 14, Issue 1 Author(s): Adam Kirton , Gabrielle deVeber Summary Stroke occurs across the lifespan with unique issues in the fetus, neonate, and child. The past decade has seen substantial advances in paediatric stroke research and clinical care, but many unanswered questions and controversies remain. The pathobiology of perinatal stroke needs to be better understood if prevention strategies are to be realised. Similarly, enhanced understanding of the mechanisms underlying childhood stroke, including cerebral arteriopathies, could inform the development of ...
Source: The Lancet Neurology - December 9, 2014 Category: Neurology Source Type: research

Effects of long-term blood pressure lowering and dual antiplatelet treatment on cognitive function in patients with recent lacunar stroke: a secondary analysis from the SPS3 randomised trial
Publication date: December 2014 Source:The Lancet Neurology, Volume 13, Issue 12 Author(s): Lesly A Pearce , Leslie A McClure , David C Anderson , Claudia Jacova , Mukul Sharma , Robert G Hart , Oscar R Benavente Background The primary outcome results for the SPS3 trial suggested that a lower systolic target blood pressure (<130 mm Hg) might be beneficial for reducing the risk of recurrent stroke compared with a higher target (130–149 mm Hg), but that the addition of clopidogrel to aspirin was not beneficial compared with aspirin plus placebo. In this prespecified secondary outcome analysis of the SPS3 trial, we...
Source: The Lancet Neurology - December 8, 2014 Category: Neurology Source Type: research

Effect of intermittent pneumatic compression on disability, living circumstances, quality of life, and hospital costs after stroke: secondary analyses from CLOTS 3, a randomised trial
Publication date: December 2014 Source:The Lancet Neurology, Volume 13, Issue 12 Background The results of the CLOTS 3 trial showed that intermittent pneumatic compression (IPC) reduced the risk of deep vein thrombosis and improved survival in immobile patients with stroke. IPC is now being widely used in stroke units. Here we describe the disability, living circumstances, quality of life, and hospital costs of patients in CLOTS 3. Methods In CLOTS 3, a parallel group trial in 94 UK hospitals, immobile patients with stroke from days 0 to 3 of admission were assigned with a computer-generated allocation sequence in a 1:1 r...
Source: The Lancet Neurology - December 8, 2014 Category: Neurology Source Type: research

Prediction of manifest Huntington's disease with clinical and imaging measures: a prospective observational study
Publication date: December 2014 Source:The Lancet Neurology, Volume 13, Issue 12 Author(s): Jane S Paulsen , Jeffrey D Long , Christopher A Ross , Deborah L Harrington , Cheryl J Erwin , Janet K Williams , Holly James Westervelt , Hans J Johnson , Elizabeth H Aylward , Ying Zhang , H Jeremy Bockholt , Roger A Barker Background Although the association between cytosine-adenine-guanine (CAG) repeat length and age at onset of Huntington's disease is well known, improved prediction of onset would be advantageous for clinical trial design and prognostic counselling. We compared various measures for tracking progression and pr...
Source: The Lancet Neurology - December 8, 2014 Category: Neurology Source Type: research

Blood pressure control after stroke: too little, too late, or too soon to tell?
Publication date: December 2014 Source:The Lancet Neurology, Volume 13, Issue 12 Author(s): Argye E Hillis
Source: The Lancet Neurology - December 8, 2014 Category: Neurology Source Type: research

Intermittent pneumatic compression after stroke
Publication date: December 2014 Source:The Lancet Neurology, Volume 13, Issue 12 Author(s): Graeme J Hankey
Source: The Lancet Neurology - December 8, 2014 Category: Neurology Source Type: research

Neuropsychiatric outcomes after stroke
Publication date: December 2014 Source:The Lancet Neurology, Volume 13, Issue 12 Author(s): Merja E Kallio
Source: The Lancet Neurology - December 8, 2014 Category: Neurology Source Type: research

Neuropsychiatric outcomes after stroke – Authors' reply
Publication date: December 2014 Source:The Lancet Neurology, Volume 13, Issue 12 Author(s): Sebastian Köhler , Maree L Hackett , John T O'Brien , Gillian E Mead
Source: The Lancet Neurology - December 8, 2014 Category: Neurology Source Type: research