Filtered By:
Source: Neuroscience Letters

This page shows you your search results in order of date. This is page number 4.

Order by Relevance | Date

Total 146 results found since Jan 2013.

Clinical and research applications of magnetic resonance imaging in the study of CADASIL
Publication date: Available online 8 January 2019Source: Neuroscience LettersAuthor(s): Dorothee Schoemaker, Yakeel T. Quiroz, Heirangi Torrico-Teave, Joseph F. Arboleda-VelasquezAbstractCerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is an inherited small vessel disease that leads to early cerebrovascular events and functional disability. It is the most common single-gene disorder leading to stroke. Magnetic resonance imaging (MRI) is a central component of the diagnosis and monitoring of CADASIL. Here we provide a descriptive review of the literature on three important...
Source: Neuroscience Letters - January 9, 2019 Category: Neuroscience Source Type: research

Neurofilament changes in serum and cerebrospinal fluid after acute ischemic stroke
ConclusionNFL and pNFH in CSF and serum are promising biomarkers for axonal injury following stroke. Further studies in larger populations are needed to fully understand the progression of the neuronal damage after acute ischemic stroke and to evaluate if these biomarkers can provide additive information and how they relate to outcome.
Source: Neuroscience Letters - December 30, 2018 Category: Neuroscience Source Type: research

Upregulation of miR-496 decreases cerebral ischemia/reperfusion injury by negatively regulating BCL2L14
In conclusions, our results suggest that miR-496 alleviates cerebral I/R injury possibly via inhibiting BCL2L14 expression.
Source: Neuroscience Letters - December 29, 2018 Category: Neuroscience Source Type: research

Glutamate receptors and white matter stroke
Publication date: Available online 23 November 2018Source: Neuroscience LettersAuthor(s): Robert Fern, Carlos MatuteAbstractWhite matter (WM) damage during ischemia occurs at multiple sites including myelin, oligodendrocytes, astrocytes and axons. A major driver of WM demise is excitoxicity as a consequence of excessive glutamate release by vesicular and non-vesicular mechanisms from axons and glial cells. This results in over-activation of ionotropic glutamate receptors profusely expressed by all cell compartments in WM. Thus, blocking excitotoxicity in WM with selective antagonists of those receptors has a potential ther...
Source: Neuroscience Letters - November 24, 2018 Category: Neuroscience Source Type: research

Activation of the α7 nicotinic acetylcholine receptor upregulates blood-brain barrier function through increased claudin-5 and occludin expression in rat brain endothelial cells
Publication date: Available online 16 November 2018Source: Neuroscience LettersAuthor(s): Ikuya Kimura, Shinya Dohgu, Fuyuko Takata, Junichi Matsumoto, Yohei Kawahara, Megumi Nishihira, Shohei Sakada, Takuya Saisho, Atsushi Yamauchi, Yasufumi KataokaAbstractThe blood-brain barrier (BBB) is formed by brain endothelial cells (BECs) and regulates brain homeostasis by restricting the entry of blood-borne substances into the brain. Recent in vivo studies have shown that administration of nicotinic acetylcholine receptor (nAChR) agonists protects against BBB disruption and neuroinflammation induced by stroke and traumatic brain ...
Source: Neuroscience Letters - November 16, 2018 Category: Neuroscience Source Type: research

Altered baseline activity and connectivity associated with cognitive impairment following acute cerebellar infarction: A resting-state fMRI study
Publication date: Available online 12 November 2018Source: Neuroscience LettersAuthor(s): Lin Fan, Jun Hu, Wenying Ma, Donghao Wang, Qun Yao, Jingping ShiAbstractThe aims of this study were to investigated the changes of brain function and cognitive function in patients with acute posterior cerebellar infarction using the functional magnetic resonance imaging (fMRI) tecniques: fractional amplitude of low-frequency fluctuation (fALFF) and functional connectivity (FC). Forty acute cerebellar infarction patients and 40 healthy controls were included. The differences of fALFF were compared. The regions showed significant diffe...
Source: Neuroscience Letters - November 14, 2018 Category: Neuroscience Source Type: research

Inhibition of protease-activated receptor 1 ameliorates behavioral deficits and restores hippocampal synaptic plasticity in a rat model of status epilepticus
Publication date: Available online 1 November 2018Source: Neuroscience LettersAuthor(s): Marharyta Semenikhina, Ruslan Bogovyk, Mykhailo Fedoriuk, Oksana Nikolaienko, Lina T. AlKury, Alina Savotchenko, Oleg Krishtal, Elena IsaevaAbstractThe blood-brain barrier (BBB) is a unique structure that controls substances exchange between the systemic circulation and the brain. Disruption of its integrity contributes to the development and progression of a variety of brain disorders including stroke, epilepsy and neurodegenerative diseases. It was shown that intracerebral thrombin level substantially increases following status epile...
Source: Neuroscience Letters - November 2, 2018 Category: Neuroscience Source Type: research

The role of TRP channels in white matter function and ischaemia
Publication date: Available online 23 October 2018Source: Neuroscience LettersAuthor(s): Marion Cornillot, Vincenzo Giacco, Nicola B. HamiltonAbstractTransient receptor potential (TRP) proteins are a large family of tetrameric non-selective cation channels that are widely expressed in the grey and white matter of the CNS, and are increasingly considered as potential therapeutic targets in brain disorders. Here we briefly review the evidence for TRP channel expression in glial cells and their possible role in both glial cell physiology and stroke. Despite their contribution to important functions, our understanding of the r...
Source: Neuroscience Letters - October 24, 2018 Category: Neuroscience Source Type: research

Cerebral White Matter Hyperintensities and Microbleeds in Acute Ischemic Stroke: Impact on Recanalization Therapies. A Review of the Literature
Publication date: 20 November 2018Source: Neuroscience Letters, Volume 687Author(s): J. Fladt, C. Kronlage, G.M. De MarchisAbstractCerebral white matter hyperintensities (WMH) and cerebral microbleeds (CMBs) are frequently seen on brain imaging acquired for acute ischemic stroke. Given the raising use of recanalization therapies - both intravenous and endovascular - the interest on the impact of WMH and CMBs on the risk of intracerebral hemorrhage and on functional outcome is growing. In this review, we will discuss the relevance of WMH and CMBs among patients with an acute ischemic stroke, focusing on the implications for...
Source: Neuroscience Letters - October 4, 2018 Category: Neuroscience Source Type: research

A new central post-stroke pain rat model: autologous blood injected thalamic hemorrhage involved increased expression of P2X4 receptor
Publication date: 20 November 2018Source: Neuroscience Letters, Volume 687Author(s): Hai-Feng Lu, Chun-Yang Xu, Lei Zhang, Lei Gan, Chan Chen, Man-Yun Yan, Xiao-Ning Guo, Qi Fang, Guang-Yin Xu, Yan-Bo Zhang, Jian-Qiang Ni, Hong-Ru ZhaoAbstractStroke is the leading cause of disability and death in the world. Central post-stroke pain (CPSP), a central neuropathic pain syndrome occurring after cerebral stroke, is a serious problem. But on account of the lack of reliable animal models, the mechanisms underlying CPSP remains poorly understood. To better understand of the pathophysiological basis of CPSP, we developed and charac...
Source: Neuroscience Letters - October 4, 2018 Category: Neuroscience Source Type: research

Miconazole stimulates post-ischemic neurogenesis and promotes functional restoration in rats
Publication date: 20 November 2018Source: Neuroscience Letters, Volume 687Author(s): Ning Li, Xiubao Song, Liangmiao Wu, Tao Zhang, Chen Zhao, Xifei Yang, Luchen Shan, Pei Yu, Yewei Sun, Yuqiang Wang, Gaoxiao Zhang, Zaijun ZhangAbstractMiconazole, a frequently used antifungal drug, has been identified with new functions to promote oligodendrocyte progenitor cells differentiation and to enhance remyelination. However, the neuroregenerative and therapeutic benefit of miconazole on ischemic stroke model have not been tested. In the present study, the effects of miconazole on a rat model of transient middle cerebral artery occ...
Source: Neuroscience Letters - October 4, 2018 Category: Neuroscience Source Type: research

Vitamin D status and its association with season, depression in stroke
ConclusionsVitamin D deficiency and insufficiency occur at high rates in acute stroke patients. Low serum vitamin D levels were associated with depression in patients with acute stroke as analyzed by both the absolute level of vitamin D and month-specific tertiles. Intervention studies are needed to determine the benefits of vitamin D supplementation for depression in poststroke patients.
Source: Neuroscience Letters - October 4, 2018 Category: Neuroscience Source Type: research

Involvement of angiotensin-(1–7) in the neuroprotection of captopril against focal cerebral ischemia
In this study, we evaluated this hypothesis using a rat model of focal cerebral ischemia. We revealed that brain ACE2 activity and Ang-(1–7) levels were significantly elevated following captopril treatment in rats with focal cerebral ischemia. More importantly, we showed that the neuroprotection provided by captopril was partially reversed by A-779, an antagonist for Ang-(1–7) receptor MAS1, indicating that Ang-(1–7) was involved in the neuroprotection of captopril. These findings have uncovered new mechanisms by which captopril protects against focal cerebral ischemia and further suggest that captopril may have prac...
Source: Neuroscience Letters - September 21, 2018 Category: Neuroscience Source Type: research

Involvement of angiotensin-(1-7) in the neuroprotection of captopril against focal cerebral ischemia
In this study, we evaluate this hypothesis using a rat model of focal cerebral ischemia. We revealed that brain ACE2 activity and Ang-(1-7) levels were significantly elevated following captopril treatment in rats with focal cerebral ischemia. More importantly, we showed that the neuroprotection provided by captopril was partially reversed by A-779, an antagonist for Ang-(1-7) receptor MAS1, indicating that Ang-(1-7) was involved in the neuroprotection of captopril. These findings have uncovered new mechanisms by which captopril protects against focal cerebral ischemia and further suggest that captopril may have practical c...
Source: Neuroscience Letters - September 14, 2018 Category: Neuroscience Source Type: research

Alterations of static functional connectivity and dynamic functional connectivity in motor execution regions after stroke
Publication date: Available online 6 September 2018Source: Neuroscience LettersAuthor(s): Jing Chen, Dalong Sun, Yonghui Shi, Wei Jin, Yanbin Wang, Qian Xi, Chuancheng RenAbstractThe aims of this study were to examine both static functional connectivity (FC) and dynamic FC alterations in motor execution regions after stroke and to investigate whether the altered static or dynamic FC was associated with the clinical behaviors in stroke patients. Seventy-six stroke patients and 55 healthy controls (HC) were recruited. Static FC and dynamic FC maps were computed based on the seeds of six core regions in motor execution networ...
Source: Neuroscience Letters - September 7, 2018 Category: Neuroscience Source Type: research