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Source: Neuroscience Letters
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Total 146 results found since Jan 2013.
A novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitor protects against cerebral ischemia–reperfusion injury in mice
Publication date: 8 April 2016 Source:Neuroscience Letters, Volume 618 Author(s): Dmitriy N. Atochin, Igor A. Schepetkin, Andrei I. Khlebnikov, Victor I. Seledtsov, Helen Swanson, Mark T. Quinn, Paul L. Huang The c-Jun N-terminal kinase (JNK) has been shown to be an important regulator of neuronal cell death. Previously, we synthesized the sodium salt of 11H-indeno[1,2-b]quinoxalin-11-one (IQ-1S) and demonstrated that it was a high-affinity inhibitor of the JNK family. In the present work, we found that IQ-1S could release nitric oxide (NO) during its enzymatic metabolism by liver microsomes. Moreover, serum nitri...
Source: Neuroscience Letters - March 4, 2016 Category: Neuroscience Source Type: research
Intravenous PEP-1-GDNF is protective after focal cerebral ischemia in rats
Publication date: 23 March 2016 Source:Neuroscience Letters, Volume 617 Author(s): Yaning Liu, Shangwu Wang, Shijian Luo, Zhendong Li, Fengyin Liang, Yanan Zhu, Zhong Pei, Ruxun Huang Glial cell line-derived neurotrophic factor (GDNF) is a potential therapeutic protein on a variety of central nervous system diseases including ischemic stroke. However, GDNF is a large molecule that cannot cross the blood–brain barrier (BBB), which is still intact in the early hours after stroke when neural rescue is possible. PEP-1 protein transduction domain can deliver protein cargo across the cell membrane and the BBB. In the...
Source: Neuroscience Letters - February 20, 2016 Category: Neuroscience Source Type: research
Role of contralesional hemisphere in paretic arm reaching in patients with severe arm paresis due to stroke: A preliminary report
Publication date: 23 March 2016 Source:Neuroscience Letters, Volume 617 Author(s): Sambit Mohapatra, Rachael Harrington, Evan Chan, Alexander W. Dromerick, Erika Y. Breceda, Michelle Harris-Love Stroke is highly prevalent and a leading cause of serious, long-term disability among American adults. Impaired movement (i.e. paresis) of the stroke-affected arm is a major contributor to post-stroke disability, yet the mechanisms of upper extremity motor recovery are poorly understood, particularly in severely impaired patients who lack hand function. To address this problem, we examined the functional relevance of the co...
Source: Neuroscience Letters - February 18, 2016 Category: Neuroscience Source Type: research
Longitudinal study on modulated corticospinal excitability throughout recovery in supratentorial stroke
This study demonstrates the quick improvement in the CSE via estimation of interhemispheric asymmetry; however, the recovery in the asymmetry continues to normalize even after reaching the threshold for normal values in CSE.
Source: Neuroscience Letters - February 18, 2016 Category: Neuroscience Source Type: research
Serum miR-132 is a risk marker of post-stroke cognitive impairment
Conclusions These results indicated that there was a substantial correlation between serum miR-132 expression and post-stroke cognitive functionality, suggesting that miR-132 may be a risk marker for PSCI. Because of the limitations of this study, the results should be treated with caution.
Source: Neuroscience Letters - January 30, 2016 Category: Neuroscience Source Type: research
Functional lateralization in cingulate cortex predicts motor recovery after basal ganglia stroke
Publication date: 2 February 2016 Source:Neuroscience Letters, Volume 613 Author(s): Yao Li, Zengai Chen, Xin Su, Xiaoliu Zhang, Ping Wang, Yajing Zhu, Qun Xu, Jianrong Xu, Shanbao Tong The basal ganglia (BG) is involved in higher order motor control such as movement planning and execution of complex motor synergies. Neuroimaging study on stroke patients specifically with BG lesions would help to clarify the consequence of BG damage on motor control. In this paper, we performed a longitudinal study in the stroke patients with lesions in BG regions across three motor recovery stages, i.e., less than 2week (Sessio...
Source: Neuroscience Letters - January 13, 2016 Category: Neuroscience Source Type: research
Clostridium butyricum pretreatment attenuates cerebral ischemia/reperfusion injury in mice via anti-oxidation and anti-apoptosis
This study aims to determine whether Clostridium butyricum (C. butyricum) could attenuate cerebral ischemia/reperfusion (I/R) injury and its possible mechanisms. Male ICR mice were intragastrically pretreated with C. butyricum for 2 successive weeks, and then subjected to cerebral I/R injury induced by the bilateral common carotid artery occlusion (BCCAO) for 20min. After 24h of the reperfusion, neurological deficit scores were evaluated. Histopathological changes of the hippocampus neurons were observed using Hematoxylin and eosin (H&E) and TUNEL staining. Malondialdehyde (MDA) contents and superoxide dismutase (S...
Source: Neuroscience Letters - January 13, 2016 Category: Neuroscience Source Type: research
siRNA mediated down-regulation of Sprouty2/4 diminishes ischemic brain injury
In this study, siRNAs directed against Sprouty2 and -4 were stereotactically injected along with the vasoconstrictive peptide endothelin-1 to create cortical infarcts in the adult rat brain. A single injection of Sprouty2/4 siRNAs (25μM each) significantly decreased Spry2 and Spry4 mRNA levels two days later and diminished the size of the injury area in the subchronic phase following vasoconstriction. Reducing Spry2/4 genetically in mice is neuroprotective and stimulates injury-induced astrogliosis which limits neuronal cell death and lesion size. The present results are consistent with the established functions of negati...
Source: Neuroscience Letters - December 4, 2015 Category: Neuroscience Source Type: research
Intraventricular Infusion of a Low Fraction of Serum Enhances Neurogenesis and Improves Recovery in a Rodent Stroke Model
In this study, we further evaluated the efficacy of intraventricular administration of 100K with bFGF (100K/bFGF) in a rat model of transient middle cerebral artery occlusion (MCAO). Rats administered 100K/bFGF on post-stroke day 1 exhibited a higher number of Ki67 and Nestin immunoreactive cells at the subventricular zone (SVZ) area and in the infarcted brain, indicating promotion of NSPCs proliferation. The 100K/bFGF treatment also predominantly increased the number of MAP-2 immunoreactive cells rather than GFAP immunoreactive cells at the SVZ area and in the infarcted regions, implying that 100K/bFGF dominated NSPCs dif...
Source: Neuroscience Letters - November 20, 2015 Category: Neuroscience Source Type: research
A new middle cerebral artery occlusion model for intra-arterial drug infusion in rats
Publication date: 21 October 2015 Source:Neuroscience Letters, Volume 607 Author(s): Wen-hao Sun, Hui-sheng Chen With the wide application of intra-arterial therapy for cerebrovascular disorders, preclinical intra-arterial drug-delivery studies based on middle cerebral artery occlusion (MCAO) models have become urgent. In the present study, a novel stroke model was developed for intra-arterial drug delivery: MCAO and drug delivery were accomplished using a microcatheter device. MCAO was induced in Sprague-Dawley rats using the microcatheter device (cMCAO group, n =10) or a nylon suture (sMCAO group, n =10). After 24-h ...
Source: Neuroscience Letters - October 4, 2015 Category: Neuroscience Source Type: research
ELR-CXC chemokine antagonism is neuroprotective in a rat model of ischemic stroke
Publication date: 8 October 2015 Source:Neuroscience Letters, Volume 606 Author(s): Barry J. Connell, John R. Gordon, Tarek M. Saleh Inflammation-related cerebral damage mediated by infiltrating neutrophils following reperfusion plays a role in reperfusion-induced brain damage subsequent to a stroke event. The ELR-CXC family of chemokines are CXCR1 and CXCR2 agonists that are known to drive neutrophil migration and activation. The present study demonstrated the benefit of anti-inflammatory therapy in the treatment of ischemic stroke with the administration of the competitive ELR-CXC chemokine antagonist, CXCL8(3–72)...
Source: Neuroscience Letters - September 4, 2015 Category: Neuroscience Source Type: research
Neuroprotective effects and dynamic expressions of MMP9 and TIMP1 associated with atorvastatin pretreatment in ischemia–reperfusion rats
In conclusion, Oral administration of atorvastatin before stroke may reduce the severity in I/R injury and improve neurological outcome by lowering MMP9 levels and elevating TIMP1 levels.
Source: Neuroscience Letters - July 30, 2015 Category: Neuroscience Source Type: research
Fluoxetine enhanced neurogenesis is not translated to functional outcome in stroke rats
Publication date: 31 August 2015 Source:Neuroscience Letters, Volume 603 Author(s): Xiaoyu Sun, Xuan Sun, Tingting Liu, Mei Zhao, Shanshan Zhao, Ting Xiao, Jukka Jolkkonen, Chuansheng Zhao Fluoxetine is widely used in clinical practice. It regulates hippocampal neurogenesis, however, the effect of fluoxetine on neurogenesis in the subventricular zone (SVZ) remains controversial. We aimed to study the effect of fluoxetine on neurogenesis in the SVZ and subgranular zone (SGZ) of dentate gyrus (DG) in relation to behavioral recovery after stroke in rats. Adult male Wistar rats were randomly assigned to four groups: ...
Source: Neuroscience Letters - July 25, 2015 Category: Neuroscience Source Type: research
Neuroprotective effects of bisperoxovanadium on cerebral ischemia by inflammation inhibition
In conclusions, Bpv treatment demonstrates neuroprotective effects on cerebral ischemia and reperfusion injury of ischemic stroke rats and is associated with its modulation of inflammatory mediator production and up-regulation of PTEN downstream proteins PI3K, Akt and p-GSK-3β.
Source: Neuroscience Letters - July 17, 2015 Category: Neuroscience Source Type: research
Association between two promoter polymorphisms (rs1893219 and rs1893220) of MC2R gene and intracerebral hemorrhage in Korean population
Publication date: 18 August 2015 Source:Neuroscience Letters, Volume 602 Author(s): Hyun-Kyung Park , Jinmann Chon , Hae Jeong Park , Joo-Ho Chung , Hyung Hwan Baik The hypothalamic–pituitary–adrenal (HPA) axis has an important role in the pathogenesis of stroke. We investigated whether single nucleotide polymorphisms (SNPs) of melanocortin 2 receptor (MC2R), also known as adrenocorticotropic hormone (ACTH) receptor, were associated with the development of intracerebral hemorrhage (ICH) in Korean population. Two promoter SNPs [rs1893219 (−853A/G) and rs1893220 (−759G/T)] were genotyped in 145 ICH patients and 331...
Source: Neuroscience Letters - July 10, 2015 Category: Neuroscience Source Type: research
