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Source: Neuropsychologia
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Total 127 results found since Jan 2013.
Voxel-based Lesion Analysis of Brain Regions Underlying Reading and Writing
Publication date: Available online 20 March 2018 Source:Neuropsychologia Author(s): Juliana V. Baldo, Natalie Kacinik, Carl Ludy, Selvi Paulraj, Amber Moncrief, Vitória Piai, Brian Curran, And Turken, Tim Herron, Nina F. Dronkers The neural basis of reading and writing has been a source of inquiry as well as controversy in the neuroscience literature. Reading has been associated with both left posterior ventral temporal zones (termed the “visual word form area”) as well as more dorsal zones, primarily in left parietal cortex. Writing has also been associated with left parietal cortex, as well as left sensorimotor cor...
Source: Neuropsychologia - March 22, 2018 Category: Neurology Source Type: research
The impact of sample size on the reproducibility of voxel-based lesion-deficit mappings
This study investigated how sample size affects the reproducibility of findings from univariate voxel-based lesion-deficit analyses (e.g., voxel-based lesion-symptom mapping and voxel-based morphometry). Our effect of interest was the strength of the mapping between brain damage and speech articulation difficulties, as measured in terms of the proportion of variance explained. First, we identified a region of interest by searching on a voxel-by-voxel basis for brain areas where greater lesion load was associated with poorer speech articulation using a large sample of 360 right-handed English-speaking stroke survivors. We t...
Source: Neuropsychologia - March 15, 2018 Category: Neurology Source Type: research
Neural Mechanisms of Two Different Verbal Working Memory Tasks: A VLSM Study
Publication date: Available online 8 March 2018 Source:Neuropsychologia Author(s): M.V. Ivanova, O.V. Dragoy, S.V. Kuptsova, S. Akinina Yu., A.G. Petrushevskii, O.N. Fedina, A. Turken, V.M. Shklovsky, N.F. Dronkers Currently, a distributed bilateral network of frontal-parietal areas is regarded as the neural substrate of working memory (WM), with the verbal WM network being more left-lateralized. This conclusion is based primarily on functional magnetic resonance imaging (fMRI) data that provides correlational evidence for brain regions involved in a task. However, fMRI cannot differentiate the areas that are fundamentall...
Source: Neuropsychologia - March 9, 2018 Category: Neurology Source Type: research
How distributed processing produces false negatives in voxel-based lesion-deficit analyses
In this study, we hypothesized that if the same deficit can be caused by damage to one or another part of a distributed neural system, then voxel-based analyses might miss critical lesion sites because preservation of each site will not be consistently associated with preserved function. The first part of our investigation used voxel-based multiple regression analyses of data from 359 right-handed stroke survivors to identify brain regions where lesion load is associated with picture naming abilities after factoring out variance related to object recognition, semantics and speech articulation so as to focus on deficits ari...
Source: Neuropsychologia - March 3, 2018 Category: Neurology Source Type: research
The neuroimaging basis of apathy: Empirical findings and conceptual challenges
Publication date: Available online 2 February 2018 Source:Neuropsychologia Author(s): Sergio E. Starkstein, Simone Brockman Apathy, usually defined as loss of motivation, is common in both neurodegenerative conditions such as Alzheimer's disease, and acute neurological disorders such as stroke. Neuroradiological studies on the imaging correlates of apathy have used a variety of methods such as structural and functional magnetic resonance imaging, diffusion tensor imaging, and single photon and positron emission tomography to assess brain metabolic activity and specific synaptic receptors. Dysfunction of the anterior cingu...
Source: Neuropsychologia - February 2, 2018 Category: Neurology Source Type: research
The Spatial Distribution of Perseverations in Neglect Patients during a Nonverbal Fluency Task Depends on the Integrity of the Right Putamen
Publication date: Available online 31 January 2018 Source:Neuropsychologia Author(s): B.C. Kaufmann, J. Frey, T. Pflugshaupt, P. Wyss, R.E. Paladini, T. Vanbellingen, S. Bohlhalter, M. Chechlacz, T. Nef, R.M. Müri, D. Cazzoli, T. Nyffeler Deficient inhibitory control leading to perseverative behaviour is often observed in neglect patients. Previous studies investigating the relationship between response inhibition and visual attention have reported contradictory results: some studies found a linear relationship between neglect severity and perseverative behaviour whereas others could not replicate this result. The aim of...
Source: Neuropsychologia - January 31, 2018 Category: Neurology Source Type: research
The structure of the mental lexicon: what primary progressive aphasias reveal
Publication date: Available online 11 December 2017 Source:Neuropsychologia Author(s): Clara Sanches, Alexandre Routier, Olivier Colliot, Marc Teichmann Like recursive syntax, a structured mental lexicon is specific to the human species but its internal organization remains unclear. It is thought to contain information about the semantic, syntactic (e.g., gender) and formal (orthographic/phonological) features of a word. Previous studies suggested that these three components might be separated at the behavioral level and that they might be implemented by temporal cortices. However, the available investigations are based o...
Source: Neuropsychologia - December 11, 2017 Category: Neurology Source Type: research
Does it fit? – Impaired affordance perception after stroke
Publication date: 8 January 2018 Source:Neuropsychologia, Volume 108 Author(s): Jennifer Randerath, Lisa Finkel, Cheryl Shigaki, Joe Burris, Ashish Nanda, Peter Hwang, Scott H. Frey Affordance perception comprises the evaluation of whether our given bodily capabilities and properties of the environment allow particular actions. Typical impairments after left brain damage in motor cognition as well as after right brain damage in visuo-spatial abilities may affect the evaluation of whether interactions with objects are possible. Further it is unclear whether deficient motor function is accounted for when deciding upon actio...
Source: Neuropsychologia - December 7, 2017 Category: Neurology Source Type: research
Does it fit? - Impaired affordance perception after stroke
Publication date: Available online 2 December 2017 Source:Neuropsychologia Author(s): Jennifer Randerath, Lisa Finkel, Cheryl Shigaki, Joe Burris, Ashish Nanda, Peter Hwang, Scott H. Frey
Source: Neuropsychologia - December 3, 2017 Category: Neurology Source Type: research
Neural correlates of improvements in personality and behavior following a neurological event
Publication date: Available online 21 November 2017 Source:Neuropsychologia Author(s): Marcie L. King, Kenneth Manzel, Joel Bruss, Daniel Tranel Research on changes in personality and behavior following brain damage has focused largely on negative outcomes, such as increased irritability, moodiness, and social inappropriateness. However, clinical observations suggest that some patients may actually show positive personality and behavioral changes following a neurological event. In the current work, we investigated neuroanatomical correlates of positive personality and behavioral changes following a discrete neurological e...
Source: Neuropsychologia - November 23, 2017 Category: Neurology Source Type: research
Neural correlates of visuospatial bias in patients with left hemisphere stroke: a causal functional contribution analysis based on game theory
Publication date: Available online 12 October 2017 Source:Neuropsychologia Author(s): C. Malherbe, R. Umarova, M. Zavaglia, C. Kaller, L. Beume, G. Thomalla, C. Weiller, C.C. Hilgetag Stroke patients frequently display spatial neglect, an inability to report, or respond to, relevant stimuli in the contralesional space. Although this syndrome is widely considered to result from the dysfunction of a large-scale attention network, the individual contributions of damaged grey and white matter regions to neglect are still being disputed. Moreover, while the neuroanatomy of neglect in right hemispheric lesions is well studied, ...
Source: Neuropsychologia - October 13, 2017 Category: Neurology Source Type: research
Timing independent spatial motor sequence learning is preserved in left hemisphere stroke
Publication date: Available online 28 September 2017 Source:Neuropsychologia Author(s): Anna Dovern, Eva Niessen, Jana M. Ant, Jochen Saliger, Hans Karbe, Gereon R. Fink, Iring Koch, Peter H. Weiss During neurorehabilitation, the re-learning of motor sequences is crucial for patients with motor deficits, enabling them to master again complex movements. A recent study showed that patients with left hemisphere (LH) stroke exhibited preserved motor sequence learning (as assessed by the serial reaction time (SRT) task) when the timing of the stimuli was comparable in the training and later test phase. However, patients showed...
Source: Neuropsychologia - September 28, 2017 Category: Neurology Source Type: research
Improved accuracy of lesion to symptom mapping with multivariate sparse canonical correlations
In this study, we propose a multivariate optimization technique known as sparse canonical correlation analysis for neuroimaging (SCCAN) for lesion to symptom mapping. To validate the method and compare it with mass-univariate results, we used data from 131 patients with chronic stroke lesions in the territory of the middle cerebral artery, and created synthetic behavioral scores based on the lesion load of 93 brain regions (putative functional units). LSM analyses were performed with univariate VLSM or SCCAN, and the accuracy of the two methods was compared in terms of both overlap and and displacement from the simulated f...
Source: Neuropsychologia - September 5, 2017 Category: Neurology Source Type: research
Corrections for multiple comparisons in voxel-based lesion-symptom mapping
Publication date: Available online 26 August 2017 Source:Neuropsychologia Author(s): Daniel Mirman, Jon-Frederick Landrigan, Spiro Kokolis, Sean Verillo, Casey Ferrara, Dorian Pustina Voxel-based lesion-symptom mapping (VLSM) is an important method for basic and translational human neuroscience research. VLSM leverages modern neuroimaging analysis techniques to build on the classic approach of examining the relationship between location of brain damage and cognitive deficits. Testing an association between deficit severity and lesion status in each voxel involves very many individual tests and requires statistical correct...
Source: Neuropsychologia - August 27, 2017 Category: Neurology Source Type: research
Artificial grammar learning in vascular and progressive non-fluent aphasias
Publication date: Available online 24 August 2017 Source:Neuropsychologia Author(s): Thomas E. Cope, Benjamin Wilson, Holly Robson, Rebecca Drinkall, Lauren Dean, Manon Grube, P. Simon Jones, Karalyn Patterson, Timothy D. Griffiths, James B. Rowe, Christopher I. Petkov Patients with non-fluent aphasias display impairments of expressive and receptive grammar. This has been attributed to deficits in processing configurational and hierarchical sequencing relationships. This hypothesis had not been formally tested. It was also controversial whether impairments are specific to language, or reflect domain general deficits in pr...
Source: Neuropsychologia - August 24, 2017 Category: Neurology Source Type: research
