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Source: Neuropsychologia
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Total 127 results found since Jan 2013.
Neural correlates of visuospatial bias in patients with left hemisphere stroke: a causal functional contribution analysis based on game theory
Publication date: 1 July 2018Source: Neuropsychologia, Volume 115Author(s): C. Malherbe, R.M. Umarova, M. Zavaglia, C.P. Kaller, L. Beume, G. Thomalla, C. Weiller, C.C. HilgetagAbstractStroke patients frequently display spatial neglect, an inability to report, or respond to, relevant stimuli in the contralesional space. Although this syndrome is widely considered to result from the dysfunction of a large-scale attention network, the individual contributions of damaged grey and white matter regions to neglect are still being disputed. Moreover, while the neuroanatomy of neglect in right hemispheric lesions is well studied, ...
Source: Neuropsychologia - July 10, 2018 Category: Neurology Source Type: research
How distributed processing produces false negatives in voxel-based lesion-deficit analyses
In this study, we hypothesized that if the same deficit can be caused by damage to one or another part of a distributed neural system, then voxel-based analyses might miss critical lesion sites because preservation of each site will not be consistently associated with preserved function. The first part of our investigation used voxel-based multiple regression analyses of data from 359 right-handed stroke survivors to identify brain regions where lesion load is associated with picture naming abilities after factoring out variance related to object recognition, semantics and speech articulation so as to focus on deficits ari...
Source: Neuropsychologia - July 10, 2018 Category: Neurology Source Type: research
Corrections for multiple comparisons in voxel-based lesion-symptom mapping
Publication date: 1 July 2018Source: Neuropsychologia, Volume 115Author(s): Daniel Mirman, Jon-Frederick Landrigan, Spiro Kokolis, Sean Verillo, Casey Ferrara, Dorian PustinaAbstractVoxel-based lesion-symptom mapping (VLSM) is an important method for basic and translational human neuroscience research. VLSM leverages modern neuroimaging analysis techniques to build on the classic approach of examining the relationship between location of brain damage and cognitive deficits. Testing an association between deficit severity and lesion status in each voxel involves very many individual tests and requires statistical correction...
Source: Neuropsychologia - July 10, 2018 Category: Neurology Source Type: research
The impact of sample size on the reproducibility of voxel-based lesion-deficit mappings
This study investigated how sample size affects the reproducibility of findings from univariate voxel-based lesion-deficit analyses (e.g., voxel-based lesion-symptom mapping and voxel-based morphometry). Our effect of interest was the strength of the mapping between brain damage and speech articulation difficulties, as measured in terms of the proportion of variance explained. First, we identified a region of interest by searching on a voxel-by-voxel basis for brain areas where greater lesion load was associated with poorer speech articulation using a large sample of 360 right-handed English-speaking stroke survivors. We t...
Source: Neuropsychologia - July 10, 2018 Category: Neurology Source Type: research
Improved accuracy of lesion to symptom mapping with multivariate sparse canonical correlations
In this study, we propose a multivariate optimization technique known as sparse canonical correlation analysis for neuroimaging (SCCAN) for lesion to symptom mapping. To validate the method and compare it with mass-univariate results, we used data from 131 patients with chronic stroke lesions in the territory of the middle cerebral artery, and created synthetic behavioral scores based on the lesion load of 93 brain regions (putative functional units). LSM analyses were performed with univariate VLSM or SCCAN, and the accuracy of the two methods was compared in terms of both overlap and displacement from the simulated funct...
Source: Neuropsychologia - July 5, 2018 Category: Neurology Source Type: research
Neural correlates of visuospatial bias in patients with left hemisphere stroke: a causal functional contribution analysis based on game theory
Publication date: 1 July 2018Source: Neuropsychologia, Volume 115Author(s): C. Malherbe, R.M. Umarova, M. Zavaglia, C.P. Kaller, L. Beume, G. Thomalla, C. Weiller, C.C. HilgetagAbstractStroke patients frequently display spatial neglect, an inability to report, or respond to, relevant stimuli in the contralesional space. Although this syndrome is widely considered to result from the dysfunction of a large-scale attention network, the individual contributions of damaged grey and white matter regions to neglect are still being disputed. Moreover, while the neuroanatomy of neglect in right hemispheric lesions is well studied, ...
Source: Neuropsychologia - July 5, 2018 Category: Neurology Source Type: research
How distributed processing produces false negatives in voxel-based lesion-deficit analyses
In this study, we hypothesized that if the same deficit can be caused by damage to one or another part of a distributed neural system, then voxel-based analyses might miss critical lesion sites because preservation of each site will not be consistently associated with preserved function. The first part of our investigation used voxel-based multiple regression analyses of data from 359 right-handed stroke survivors to identify brain regions where lesion load is associated with picture naming abilities after factoring out variance related to object recognition, semantics and speech articulation so as to focus on deficits ari...
Source: Neuropsychologia - July 5, 2018 Category: Neurology Source Type: research
Corrections for multiple comparisons in voxel-based lesion-symptom mapping
Publication date: 1 July 2018Source: Neuropsychologia, Volume 115Author(s): Daniel Mirman, Jon-Frederick Landrigan, Spiro Kokolis, Sean Verillo, Casey Ferrara, Dorian PustinaAbstractVoxel-based lesion-symptom mapping (VLSM) is an important method for basic and translational human neuroscience research. VLSM leverages modern neuroimaging analysis techniques to build on the classic approach of examining the relationship between location of brain damage and cognitive deficits. Testing an association between deficit severity and lesion status in each voxel involves very many individual tests and requires statistical correction...
Source: Neuropsychologia - July 5, 2018 Category: Neurology Source Type: research
The impact of sample size on the reproducibility of voxel-based lesion-deficit mappings
This study investigated how sample size affects the reproducibility of findings from univariate voxel-based lesion-deficit analyses (e.g., voxel-based lesion-symptom mapping and voxel-based morphometry). Our effect of interest was the strength of the mapping between brain damage and speech articulation difficulties, as measured in terms of the proportion of variance explained. First, we identified a region of interest by searching on a voxel-by-voxel basis for brain areas where greater lesion load was associated with poorer speech articulation using a large sample of 360 right-handed English-speaking stroke survivors. We t...
Source: Neuropsychologia - July 5, 2018 Category: Neurology Source Type: research
Lesion mapping in acute stroke aphasia and its implications for recovery
Publication date: 1 July 2018Source: Neuropsychologia, Volume 115Author(s): Stephanie J. Forkel, Marco CataniAbstractPatients with stroke offer a unique window into understanding human brain function. Mapping stroke lesions poses several challenges due to the complexity of the lesion anatomy and the mechanisms causing local and remote disruption on brain networks. In this prospective longitudinal study, we compare standard and advanced approaches to white matter lesion mapping applied to acute stroke patients with aphasia. Eighteen patients with acute left hemisphere stroke were recruited and scanned within two weeks from ...
Source: Neuropsychologia - July 5, 2018 Category: Neurology Source Type: research
Voxel-based lesion analysis of brain regions underlying reading and writing
Publication date: 1 July 2018Source: Neuropsychologia, Volume 115Author(s): Juliana V. Baldo, Natalie Kacinik, Carl Ludy, Selvi Paulraj, Amber Moncrief, Vitória Piai, Brian Curran, And Turken, Tim Herron, Nina F. DronkersAbstractThe neural basis of reading and writing has been a source of inquiry as well as controversy in the neuroscience literature. Reading has been associated with both left posterior ventral temporal zones (termed the “visual word form area”) as well as more dorsal zones, primarily in left parietal cortex. Writing has also been associated with left parietal cortex, as well as left sensorimotor corte...
Source: Neuropsychologia - July 5, 2018 Category: Neurology Source Type: research
The spatial distribution of perseverations in neglect patients during a nonverbal fluency task depends on the integrity of the right putamen
Publication date: 1 July 2018Source: Neuropsychologia, Volume 115Author(s): B.C. Kaufmann, J. Frey, T. Pflugshaupt, P. Wyss, R.E. Paladini, T. Vanbellingen, S. Bohlhalter, M. Chechlacz, T. Nef, R.M. Müri, D. Cazzoli, T. NyffelerAbstractDeficient inhibitory control leading to perseverative behaviour is often observed in neglect patients. Previous studies investigating the relationship between response inhibition and visual attention have reported contradictory results: some studies found a linear relationship between neglect severity and perseverative behaviour whereas others could not replicate this result. The aim of the...
Source: Neuropsychologia - July 5, 2018 Category: Neurology Source Type: research
Neural mechanisms of two different verbal working memory tasks: A VLSM study
Publication date: 1 July 2018Source: Neuropsychologia, Volume 115Author(s): M.V. Ivanova, O. Dragoy, S.V. Kuptsova, S. Yu. Akinina, A.G. Petrushevskii, O.N. Fedina, A. Turken, V.M. Shklovsky, N.F. DronkersAbstractCurrently, a distributed bilateral network of frontal-parietal areas is regarded as the neural substrate of working memory (WM), with the verbal WM network being more left-lateralized. This conclusion is based primarily on functional magnetic resonance imaging (fMRI) data that provides correlational evidence for brain regions involved in a task. However, fMRI cannot differentiate the areas that are fundamentally ...
Source: Neuropsychologia - July 5, 2018 Category: Neurology Source Type: research
Silent pauses in aphasia
Publication date: Available online 7 April 2018 Source:Neuropsychologia Author(s): Georgia Angelopoulou, Dimitrios Kasselimis, George Makrydakis, Maria Varkanitsa, Petros Roussos, Dionysis Goutsos, Ioannis Evdokimidis, Constantin Potagas Pauses may be studied as an aspect of the temporal organization of speech, as well as an index of internal cognitive processes, such as word access, selection and retrieval, monitoring, articulatory planning, and memory. Several studies have demonstrated specific distributional patterns of pauses in typical speech. However, evidence from patients with language impairment is sparse and res...
Source: Neuropsychologia - April 8, 2018 Category: Neurology Source Type: research
Lesion mapping in acute stroke aphasia and its implications for recovery
Publication date: Available online 30 March 2018 Source:Neuropsychologia Author(s): Stephanie J Forkel, Marco Catani Patients with stroke lesions offer a unique window into understanding human brain function. Studying stroke lesions poses several challenges due to the complexity of the lesion anatomy and the mechanisms causing local and remote disruptions on brain networks. In this prospective longitudinal study, we compare standard and advanced approaches to white matter lesion mapping applied to acute stroke patients with aphasia. Eighteen patients with acute left hemisphere stroke were recruited and scanned within two ...
Source: Neuropsychologia - March 31, 2018 Category: Neurology Source Type: research
