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Source: Journal of Ethnopharmacology
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Total 77 results found since Jan 2013.
Anti-inflammatory and anti-allergic effects and underlying mechanisms of Huang-Lian-Jie-Du extract: Implication for atopic dermatitis treatment
Conclusions HLJDE exerted significant anti-inflammatory and anti-allergic effects through suppressing the production of allergic and inflammatory mediators via the NF-κB and MAPKs inactivation and IκBα degradation in the LPS-stimulated RAW24.7 cells, inactivation of MAPKs and Lyn pathway in antigen-induced RBL-2H3 cells. The present study provides in vitro experimental evidence to support the use of HLJDE for the clinical treatment of AD. Graphical abstract
Source: Journal of Ethnopharmacology - March 21, 2016 Category: Drugs & Pharmacology Source Type: research
Geniposide attenuates inflammatory response by suppressing P2Y14 receptor and downstream ERK1/2 signaling pathway in oxygen and glucose deprivation-induced brain microvascular endothelial cells
Conclusion Geniposide exerted anti-inflammatory effects by interfering with the expression of P2Y14 receptor, which subsequently inhibits the downstream ERK1/2 signaling pathways and the release of the pro-inflammatory cytokines IL-8, MCP-1, IL-1β. Therefore, this study provides the evidence for gardenia's clinical application in cerebral ischemia. Graphical abstract
Source: Journal of Ethnopharmacology - March 21, 2016 Category: Drugs & Pharmacology Source Type: research
Effects of salvianolic acid B and tanshinone IIA on the pharmacokinetics of losartan in rats by regulating the activities and expression of CYP3A4 and CYP2C9
Publication date: 2 March 2016 Source:Journal of Ethnopharmacology, Volume 180 Author(s): Rong Wang, Hai Zhang, Yujie Wang, Xiaoyan Yu, Yongfang Yuan Losartan (LST) is a common chemical drug used to treat high blood pressure and reduce the risk of stroke in certain people with heart disease. Danshen, prepared from the dried root and rhizome of Salvia miltiorrhiza Bunge, has been widely used for prevention and treatment of various cardiovascular and cerebrovascular diseases. There are more than 35 formulations containing Danshen indexed in the 2010 Chinese Pharmacopoeia, which are often combined with LST to treat car...
Source: Journal of Ethnopharmacology - February 6, 2016 Category: Drugs & Pharmacology Source Type: research
Anti-platelet and anti-thrombotic effect of a traditional herbal medicine Kyung-Ok-Ko
Conclusions These findings suggest that KOK elicits remarkable anti-platelet and anti-thrombotic effects with less side effect of bleeding, and therefore, it may have a therapeutic potential for the prevention of platelet-associated cardiovascular diseases. Graphical abstract
Source: Journal of Ethnopharmacology - December 17, 2015 Category: Drugs & Pharmacology Source Type: research
Cassia obtusifolia seed ameliorates amyloid β-induced synaptic dysfunction through anti-inflammatory and Akt/GSK-3β pathways
Conclusion These results suggest that COE exhibits neuroprotective activities against Aβ-induced brain disorders. Graphical abstract
Source: Journal of Ethnopharmacology - December 15, 2015 Category: Drugs & Pharmacology Source Type: research
Induced cortical neurogenesis after focal cerebral ischemia – Three active components from Huang-Lian-Jie-Du Decoction
Conclusions Total alkaloids, iridoids and flavonoids from HLJDD promoted functional recovery likely via enhancing cortical neurogenesis and thus have potential as a treatment for ischemic brain injury. Graphical abstract
Source: Journal of Ethnopharmacology - December 15, 2015 Category: Drugs & Pharmacology Source Type: research
Outcomes after stroke in patients receiving adjuvant therapy with traditional Chinese medicine: A nationwide matched interventional cohort study
Conclusions Hospitalized stroke patients who received routine care and adjuvant TCM therapy exhibited reduced adverse outcomes after admission within a 6-month follow-up period. Graphical abstract
Source: Journal of Ethnopharmacology - November 30, 2015 Category: Drugs & Pharmacology Source Type: research
Anti-apoptotic effect of modified Chunsimyeolda-tang, a traditional Korean herbal formula, on MPTP-induced neuronal cell death in a Parkinson's disease mouse model
Publication date: 24 December 2015 Source:Journal of Ethnopharmacology, Volume 176 Author(s): Huan Li, Gunhyuk Park, Nayoung Bae, Joonki Kim, Myung Sook Oh, Hyun Ok Yang Ethnopharmacological relevance The modified-Chungsimyeolda-tang (DG) is an important traditional Korean herbal formula used in traditional oriental medicine for treatment of cerebrovascular disorders, including stroke. The formula is based on the book “Dongui Sasang Shinpyun”. Aim of the study In the previous studies, the neuroprotective effect of DG is demonstrated in an in vitro Parkinson's disease (PD) model, and in this study, the 1-Methyl...
Source: Journal of Ethnopharmacology - November 23, 2015 Category: Drugs & Pharmacology Source Type: research
Prescription patterns of traditional Chinese medicine for peptic ulcer disease in Taiwan: A nationwide population-based study
Conclusions Our study identified the core prescription patterns of TCM for patients with peptic ulcer disease in Taiwan. Further basic and clinical studies are necessary to elucidate the efficacy and mechanisms. Graphical abstract
Source: Journal of Ethnopharmacology - November 18, 2015 Category: Drugs & Pharmacology Source Type: research
Common and unique mechanisms of Chinese herbal remedies on ischemic stroke mice revealed by transcriptome analyses
Conclusion: Our results suggest that using CHR, a combinatory cocktail therapy, is a better way than rt-PA for treating cerebral ischemic-associated diseases through modulating a common as well as a specific group of genes/pathways that may partially explain the syndrome differentiation and treatment principle in TCM. Graphical abstract
Source: Journal of Ethnopharmacology - September 16, 2015 Category: Drugs & Pharmacology Source Type: research
Medicinal uses, phytochemistry and pharmacology of the genus Uncaria
Conclusion Preliminary investigations on pharmacological properties of the Uncaria species have enlightened their efficacious remedy for hypertension, asthma, cancer, diabetes, rheumatism and neurodegenerative diseases. To ensure the safety and effectiveness in clinical application, research on bioactive compounds, pharmacological mechanisms and toxicity of the genus Uncaria as well as the stereo-chemistry and structure-activity relationships of indole alkaloids seem very important. Graphical abstract
Source: Journal of Ethnopharmacology - July 26, 2015 Category: Drugs & Pharmacology Source Type: research
Prescription patterns of Chinese herbal products for patients with fractures in Taiwan: A nationwide population-based study
Conclusions Our study identified the TCM utilization for patients with fractures in Taiwan. Integration of TCM treatment reduced the medical costs for hospitalization. Further basic research and clinical studies to investigate the mechanism and clinical efficacies of CHPs are warranted. Graphical abstract
Source: Journal of Ethnopharmacology - July 26, 2015 Category: Drugs & Pharmacology Source Type: research
Alteration of glutamate/GABA balance during acute alcohol intoxication in rats: Effect of Xingnaojing injection
Conclusions The current changes in glutamate, GABA and mRNA expressions of related receptors in LHA after injection of XNJI suggest that changes in these neurotransmitters and receptors as a potential mechanism of action for AAI. Graphical abstract
Source: Journal of Ethnopharmacology - April 5, 2015 Category: Drugs & Pharmacology Source Type: research
Persimmon (Diospyros kaki L.) leaves: A review on traditional uses, phytochemistry and pharmacological properties
Conclusions Persimmon leaves probably have therapeutic potential in the prevention and treatment for cerebral arteriosclerosis, diabetes, hypertension. It showed significant neuroprotection against ischemia/reperfusion injury in vivo and in vitro. Moreover, it can regulate immune function and inhibite inflammation. Further investigations are needed to explore individual bioactive compounds responsible for these pharmacological effects in vitro and in vivo and the mode of actions. Further safety assessments and clinical trials should be performed before it can be integrated into medicinal practices. Graphical abstract
Source: Journal of Ethnopharmacology - February 21, 2015 Category: Drugs & Pharmacology Source Type: research
Neuroprotective effect of modified Chungsimyeolda-tang, a traditional Korean herbal formula, via autophagy induction in models of Parkinson׳s disease
This study suggests that DG is an attractive candidate drug for inducing autophagy and, therefore, may represent a promising strategy to prevent diseases associated with misfolded/aggregated proteins in various neurodegenerative disorders, including Parkinson׳s disease. Graphical abstract
Source: Journal of Ethnopharmacology - November 28, 2014 Category: Drugs & Pharmacology Source Type: research
