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Source: Journal of Ethnopharmacology

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Total 77 results found since Jan 2013.

Anti-atherosclerosis and cardio-protective effects of the Angong Niuhuang Pill on a high fat and vitamin D3 induced rodent model of atherosclerosis
Conclusions We have demonstrated that ANP has robust ant-atherosclerosis and cardio-protective effects on a high-fat and vitamin D3 – induced rodent model of atherosclerosis due to its antiplatelet aggregation, lipid regulatory, antioxidant, anti-inflammatory and anti-apoptotic properties. Graphical abstract
Source: Journal of Ethnopharmacology - December 24, 2016 Category: Drugs & Pharmacology Source Type: research

Locally and traditionally used Ligusticum species – A review of their phytochemistry, pharmacology and pharmacokinetics
Conclusion The pthalides, organic acids and alkaloids of Ligusticum species have emerged as a good source of traditional medicines for the management of cardio- and cerebrovascular conditions, inflammation and neurogenerative disorders. The species discussed in this review have demonstrated wide pharmacological actions and have great potential to yield multipotent drugs if challenges such as poor bioavailability, solubility and toxicological profiles are addressed. Apart from the rhizomes, pharmacological activities of other botanical parts also need to be studied further. Expansion of research to cover other species in th...
Source: Journal of Ethnopharmacology - October 26, 2016 Category: Drugs & Pharmacology Source Type: research

Mechanistic understanding of the effect of Dengzhan Shengmai capsule on the pharmacokinetics of clopidogrel in rats
Conclusions DZSM significantly affects the pharmacokinetics of clopidogrel and its active metabolite by inhibiting the P-gp-mediated efflux transport and CYP450-mediated metabolism of clopidogrel. Thus, caution is needed when DZSM is co-administered with clopidogrel in the clinic because the interaction of these drugs may result in altered plasma concentrations of clopidogrel and its active metabolite. Graphical abstract
Source: Journal of Ethnopharmacology - August 7, 2016 Category: Drugs & Pharmacology Source Type: research

Neuroprotective effect and mechanism of Mu-Xiang-You-Fang on cerebral ischemia-reperfusion injury in rats
Conclusions The above data suggested that MXYF has potential neuroprotective activities by the regulation of apoptotic pathway, MXYF is a promising agent in treatment of stroke. Graphical abstract
Source: Journal of Ethnopharmacology - July 26, 2016 Category: Drugs & Pharmacology Source Type: research

Catalpol stimulates VEGF production via the JAK2/STAT3 pathway to improve angiogenesis in rats ’ stroke model
Conclusion Catalpol affects neuroprotection and angiogenesis via the JAK2/STAT3 signaling pathway, which is mediated by STAT3 activation and VEGF expression. Catalpol may be used as a potential therapeutic drug for stroke. Graphical abstract
Source: Journal of Ethnopharmacology - July 20, 2016 Category: Drugs & Pharmacology Source Type: research

Inhibitory activities of major anthraquinones and other constituents from Cassia obtusifolia against β-secretase and cholinesterases
Conclusion The findings of the present study suggest the potential of C. obtusifolia and its major constituents for use in the development of therapeutic or preventive agents for AD, especially through inhibition of AChE, BChE and BACE1 activities. Graphical abstract
Source: Journal of Ethnopharmacology - June 23, 2016 Category: Drugs & Pharmacology Source Type: research

Catalpol stimulates VEGF production via the JAK2/STAT3 pathway to improve angiogenesis in rats’ stroke model
Conclusion Catalpol affects neuroprotection and angiogenesis via the JAK2/STAT3 signaling pathway, which is mediated by STAT3 activation and VEGF expression. Catalpol may be used as a potential therapeutic drug for stroke. Graphical abstract
Source: Journal of Ethnopharmacology - June 23, 2016 Category: Drugs & Pharmacology Source Type: research

Pheretima aspergillum decoction suppresses inflammation and relieves asthma in a mouse model of bronchial asthma by NF-κB inhibition
Conclusions PAD effectively inhibited the activation of NF-κB signaling in the lungs of mice with OVA-induced asthma, and mitigated AHR and Th2 type inflammatory reactions. Therefore, PAD may serve as a drug candidate for asthma treatment. Graphical abstract
Source: Journal of Ethnopharmacology - May 19, 2016 Category: Drugs & Pharmacology Source Type: research

Neuroprotective effects of Danggui-Jakyak-San on rat stroke model through antioxidant/antiapoptotic pathway
Conclusion These suggest that DJ ameliorate the neurological dysfunction of cerebral ischemia through augmentation of antioxidant defense system and up-regulation of STAT3 and Pim-1. Graphical abstract
Source: Journal of Ethnopharmacology - May 16, 2016 Category: Drugs & Pharmacology Source Type: research

Emodin from Polygonum multiflorum ameliorates oxidative toxicity in HT22 cells and deficits in photothrombotic ischemia
Conclusions These results suggest that emodin may afford a significant neuroprotective effect against glutamate-induced apoptosis through activation of the PI3K/Akt signaling pathway, and subsequently enhance behavioral function in cerebral ischemia. Graphical abstract
Source: Journal of Ethnopharmacology - May 11, 2016 Category: Drugs & Pharmacology Source Type: research

Characteristics of traditional Chinese medicine usage in patients with stroke in Taiwan: A nationwide population-based study
Conclusion Adjunctive TCM use may reduce the risk of mortality rate among stroke patients. Bu-yang-huan-wu-tang and Dan-shen are the most common prescribed Chinese herbal formula and single herb for stroke patients, respectively. Future study investigating the anti-inflammatory and neuroprotective efficacy of Bu-yang-huan-wu-tang and Dan-shen in stroke is warranted. Graphical abstract
Source: Journal of Ethnopharmacology - April 22, 2016 Category: Drugs & Pharmacology Source Type: research

1H NMR-based metabonomics revealed protective effect of Naodesheng bioactive extract on ischemic stroke rats
Conclusions These results revealed that Naodesheng had protective effect on ischemic stroke rats and the underlying mechanisms involved multiple metabolic pathways, including energy metabolism, amino acid metabolism, oxidative stress and inflammatory injury. The present study could provide evidence that metabonomics revealed its capacity to evaluate the holistic efficacy of traditional Chinese medicine and explore the underlying mechanisms. Graphical abstract
Source: Journal of Ethnopharmacology - April 17, 2016 Category: Drugs & Pharmacology Source Type: research

Wuling powder prevents the depression-like behavior in learned helplessness mice model through improving the TSPO mediated-mitophagy
Conclusions Our results suggested that Wuling powder exhibited an obvious antidepressant effect, which could be due to the improvement of TSPO-mediated mitophagy signaling pathway.
Source: Journal of Ethnopharmacology - April 13, 2016 Category: Drugs & Pharmacology Source Type: research

Post-ischemic treatment of WIB801C, standardized Cordyceps extract, reduces cerebral ischemic injury via inhibition of inflammatory cell migration
Conclusions In summary, post-ischemic treatment of WIB801C reduced infiltration of inflammatory cells into ischemic lesions via inhibition of chemotaxis, which confers long-lasting histological and neurological protection in ischemic brain. WIB801C may be a promising anti-ischemic drug candidate with clinically relevant therapeutic time window and safety. Graphical abstract
Source: Journal of Ethnopharmacology - April 12, 2016 Category: Drugs & Pharmacology Source Type: research

Decreased risk of stroke in patients receiving traditional Chinese medicine for vertigo: A population-based cohort study
Conclusions Results of this population-based study support the effects of TCM on reducing stroke risk, and may provide a reference for stroke prevention strategies. The study results may also help to integrate TCM into clinical intervention programs that provide a favorable prognosis for vertigo patients. Graphical abstract
Source: Journal of Ethnopharmacology - March 22, 2016 Category: Drugs & Pharmacology Source Type: research