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Racial-Ethnic Disparities in Acute Stroke Care in the Florida-Puerto Rico Collaboration to Reduce Stroke Disparities Study Epidemiology
We examined race‐ethnic disparities in acute stroke performance metrics in a voluntary stroke registry among Florida and Puerto Rico Get With the Guidelines‐Stroke hospitals.Methods and ResultsSeventy‐five sites in the Florida Puerto Rico Stroke Registry (66 Florida and 9 Puerto Rico) recorded 58 864 ischemic stroke cases (2010–2014). Logistic regression models examined racial‐ethnic differences in acute stroke performance measures and defect‐free care (intravenous tissue plasminogen activator treatment, in‐hospital antithrombotic therapy, deep vein thrombosis prophylaxis, discharge antithrombotic therapy, a...
Source: JAHA:Journal of the American Heart Association - February 14, 2017 Category: Cardiology Authors: Sacco, R. L., Gardener, H., Wang, K., Dong, C., Ciliberti-Vargas, M. A., Gutierrez, C. M., Asdaghi, N., Burgin, W. S., Carrasquillo, O., Garcia-Rivera, E. J., Nobo, U., Oluwole, S., Rose, D. Z., Waters, M. F., Zevallos, J. C., Robichaux, M., Waddy, S. P., Tags: Epidemiology, Race and Ethnicity, Treatment, Cerebrovascular Disease/Stroke Original Research Source Type: research

"Life's Simple 7" and Long-Term Mortality After Stroke Stroke
Conclusions Achieving a greater number of ideal cardiovascular health metrics is associated with lower long-term risk of dying after stroke. Specifically targeting "Life's Simple 7" goals might have a profound impact, extending survival after stroke.
Source: JAHA:Journal of the American Heart Association - November 20, 2015 Category: Cardiology Authors: Lin, M. P., Ovbiagele, B., Markovic, D., Towfighi, A. Tags: Stroke Source Type: research

Impact of Increased Early Statin Administration on Ischemic Stroke Outcomes: A Multicenter Electronic Medical Record Intervention Stroke
Conclusions A simple EMR change increased early statin administration in ischemic stroke and was associated with improved clinical outcomes. This is, to our knowledge, the first EMR intervention study to show that a modification of an electronic order set resulted in improved clinical outcomes.
Source: JAHA:Journal of the American Heart Association - July 28, 2016 Category: Cardiology Authors: Flint, A. C., Conell, C., Klingman, J. G., Rao, V. A., Chan, S. L., Kamel, H., Cullen, S. P., Faigeles, B. S., Sidney, S., Johnston, S. C. Tags: Ischemic Stroke, Neuroprotectants Source Type: research

Impact of Insurance Status on Outcomes and Use of Rehabilitation Services in Acute Ischemic Stroke: Findings From Get With The Guidelines-Stroke Health Services and Outcomes Research
The objective was to determine whether patients without insurance or with government‐sponsored insurance had worse quality of care or in‐hospital outcomes in acute ischemic stroke.Methods and ResultsMultivariable logistic regressions with generalized estimating equations stratified by age under or at least 65 years were adjusted for patient demographics and comorbidities, presenting factors, and hospital characteristics to determine differences in in‐hospital mortality and postdischarge destination. We included 589 320 ischemic stroke patients treated at 1604 US hospitals participating in the Get With The Guideline...
Source: JAHA:Journal of the American Heart Association - November 13, 2016 Category: Cardiology Authors: Medford-Davis, L. N., Fonarow, G. C., Bhatt, D. L., Xu, H., Smith, E. E., Suter, R., Peterson, E. D., Xian, Y., Matsouaka, R. A., Schwamm, L. H. Tags: Ischemic Stroke Original Research Source Type: research

Elucidating the Association Between Depressive Symptoms, Coronary Heart Disease, and Stroke in Black and White Adults: The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study Epidemiology
Conclusions Proximal depressive symptoms were associated with incident fatal and nonfatal stroke and CVD death even after controlling for multiple explanatory factors, further supporting the urgent need for timely management of depressive symptoms.
Source: JAHA:Journal of the American Heart Association - August 11, 2016 Category: Cardiology Authors: Moise, N., Khodneva, Y., Richman, J., Shimbo, D., Kronish, I., Safford, M. M. Tags: Quality and Outcomes Epidemiology Source Type: research

The American Heart Association Life's Simple 7 and Incident Cognitive Impairment: The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study Epidemiology
Conclusions Compared with low CVH, intermediate and high CVH were both associated with substantially lower incidence of cognitive impairment. We did not observe a dose-response pattern; people with intermediate and high levels of CVH had similar incidence of cognitive impairment. This suggests that even when high CVH is not achieved, intermediate levels of CVH are preferable to low CVH.
Source: JAHA:Journal of the American Heart Association - June 11, 2014 Category: Cardiology Authors: Thacker, E. L., Gillett, S. R., Wadley, V. G., Unverzagt, F. W., Judd, S. E., McClure, L. A., Howard, V. J., Cushman, M. Tags: Epidemiology Source Type: research

HDL-3 is a Superior Predictor of Carotid Artery Disease in a Case-Control Cohort of 1725 Participants Stroke
Conclusions This study is the first to contrast the associations of HDL-2 and HDL-3 with CAAD. We found that HDL-3 levels were more predictive of CAAD status than HDL-2, HDL-C, or apolipoprotein A1. In addition, for men, paraoxonase 1 activity improved the overall model prediction for CAAD independently and additively with HDL-3 levels. Further investigation into the molecular mechanisms through which HDL-3 is associated with protection from CAAD is warranted.
Source: JAHA:Journal of the American Heart Association - June 25, 2014 Category: Cardiology Authors: Kim, D. S., Burt, A. A., Rosenthal, E. A., Ranchalis, J. E., Eintracht, J. F., Hatsukami, T. S., Furlong, C. E., Marcovina, S., Albers, J. J., Jarvik, G. P. Tags: Stroke Source Type: research

Management of Vascular Risk Factors in the Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST) Stroke
Conclusions Site-based risk-factor control improved significantly in the first 6 months and over the long term in CREST but was often suboptimal. Intensive medical management should be considered for future trials of carotid revascularization. Clinical Trial Registration URL: ClinicalTrials.gov. Unique identifier: NCT00004732.
Source: JAHA:Journal of the American Heart Association - November 26, 2014 Category: Cardiology Authors: Meschia, J. F., Voeks, J. H., Leimgruber, P. P., Mantese, V. A., Timaran, C. H., Chiu, D., Demaerschalk, B. M., Howard, V. J., Hughes, S. E., Longbottom, M., Howard, A. G., Brott, T. G. Tags: Stroke Source Type: research

ABCA1-Mediated Cholesterol Efflux Capacity to Cerebrospinal Fluid Is Reduced in Patients With Mild Cognitive Impairment and Alzheimer's Disease Stroke
Conclusions In people with MCI and AD, the capacity of CSF to facilitate ABCA1-mediated cholesterol efflux is impaired. This lesser cholesterol efflux in MCI supports a pathophysiological role for ABCA1-mediated cholesterol transport in early neurodegeneration.
Source: JAHA:Journal of the American Heart Association - February 12, 2016 Category: Cardiology Authors: Yassine, H. N., Feng, Q., Chiang, J., Petrosspour, L. M., Fonteh, A. N., Chui, H. C., Harrington, M. G. Tags: Lipids and Cholesterol Stroke Source Type: research

Concentration of Smaller High-Density Lipoprotein Particle (HDL-P) Is Inversely Correlated With Carotid Intima Media Thickening After Confounder Adjustment: The Multi Ethnic Study of Atherosclerosis (MESA) Stroke
Conclusions Small+medium HDL-P is significantly and inversely correlated with cIMT measurements. Correlation of small+medium HDL-P with cardioprotective paraoxonase 1 activity may reflect a functional aspect of HDL responsible for this finding.
Source: JAHA:Journal of the American Heart Association - May 19, 2016 Category: Cardiology Authors: Kim, D. S., Li, Y. K., Bell, G. A., Burt, A. A., Vaisar, T., Hutchins, P. M., Furlong, C. E., Otvos, J. D., Polak, J. F., Arnan, M. K., Kaufman, J. D., McClelland, R. L., Longstreth, W. T., Jarvik, G. P. Tags: Lipids and Cholesterol, Oxidant Stress, Cardiovascular Disease, Cerebrovascular Disease/Stroke Source Type: research

Cardiovascular Health and Healthcare Utilization and Expenditures Among Medicare Beneficiaries: The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study Health Services and Outcomes Research
ConclusionsBetter cardiovascular health is associated with lower risk for inpatient encounters and lower inpatient and outpatient healthcare expenditures.
Source: JAHA:Journal of the American Heart Association - February 1, 2017 Category: Cardiology Authors: Aaron, K. J., Colantonio, L. D., Deng, L., Judd, S. E., Locher, J. L., Safford, M. M., Cushman, M., Kilgore, M. L., Becker, D. J., Muntner, P. Tags: Cardiovascular Disease, Risk Factors, Cost-Effectiveness, Health Services, Statements and Guidelines Original Research Source Type: research

Race-Sex Differences in Statin Use and Low-Density Lipoprotein Cholesterol Control Among People With Diabetes Mellitus in the Reasons for Geographic and Racial Differences in Stroke Study Health Services and Outcomes Research
BackgroundStatin therapy is a cornerstone of cardiovascular disease risk reduction for people with diabetes mellitus. Past reports have shown race‐sex differences in statin use in general populations, but statin patterns by race and sex in those with diabetes mellitus have not been thoroughly studied.Methods and ResultsOur sample of 4288 adults ≥45 years of age with diagnosed diabetes mellitus who had low‐density lipoprotein cholesterol (LDL‐C)>100 mg/dL or were taking statins recruited for the Reasons for Geographic and Racial Differences in Stroke study from 2003 to 2007. Exposures included race‐sex groups (w...
Source: JAHA:Journal of the American Heart Association - May 10, 2017 Category: Cardiology Authors: Gamboa, C. M., Colantonio, L. D., Brown, T. M., Carson, A. P., Safford, M. M. Tags: Lipids and Cholesterol, Diabetes, Type 2, Epidemiology, Race and Ethnicity, Health Services Original Research Source Type: research

Gastric Bypass Surgery Produces a Durable Reduction in Cardiovascular Disease Risk Factors and Reduces the Long-Term Risks of Congestive Heart Failure Preventive Cardiology
ConclusionsGastric bypass is associated with a reduced risk of major cardiovascular events and the development of congestive heart failure.
Source: JAHA:Journal of the American Heart Association - May 23, 2017 Category: Cardiology Authors: Benotti, P. N., Wood, G. C., Carey, D. J., Mehra, V. C., Mirshahi, T., Lent, M. R., Petrick, A. T., Still, C., Gerhard, G. S., Hirsch, A. G. Tags: Cardiomyopathy, Heart Failure, Metabolic Syndrome, Remodeling, Cerebrovascular Disease/Stroke Original Research Source Type: research

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