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Prevalence of Cardiovascular Disease and Its Risk Factors in Primary AldosteronismNovelty and Significance Primary Aldosteronism
There have been several clinical studies examining the factors associated with cardiovascular disease (CVD) in patients with primary aldosteronism (PA); however, their results have left it unclear whether CVD is affected by the plasma aldosterone concentration or hypokalemia. We assessed the PA database established by the multicenter JPAS (Japan Primary Aldosteronism Study) and compared the prevalence of CVD among patients with PA with that among age-, sex-, and blood pressure-matched essential hypertension patients and participants with hypertension in a general population cohort. We also performed binary logistic regress...
Source: Hypertension - February 7, 2018 Category: Cardiology Authors: Youichi Ohno, Masakatsu Sone, Nobuya Inagaki, Toshinari Yamasaki, Osamu Ogawa, Yoshiyu Takeda, Isao Kurihara, Hiroshi Itoh, Hironobu Umakoshi, Mika Tsuiki, Takamasa Ichiȷo, Takuyuki Katabami, Yasushi Tanaka, Norio Wada, Yui Shibayama, Takanobu Yosh Tags: Cardiovascular Disease, Risk Factors, Hypertension, Vascular Disease Original Articles Source Type: research

Uric Acid Is a Strong Risk Marker for Developing Hypertension From PrehypertensionNovelty and Significance Hyperuricemia and Prehypertension
Prehypertension frequently progresses to hypertension, a condition associated with high morbidity and mortality from cardiovascular diseases and stroke. However, the risk factors for developing hypertension from prehypertension remain poorly understood. We conducted a retrospective cohort study using the data from 3584 prehypertensive Japanese adults (52.1±11.0 years, 2081 men) found to be prehypertensive in 2004 and reexamined in 2009. We calculated the cumulative incidences of hypertension over 5 years, examined risk factors, and calculated odds ratios (ORs) for developing hypertension after adjustments for age, sex, bo...
Source: Hypertension - December 13, 2017 Category: Cardiology Authors: Masanari Kuwabara, Ichiro Hisatome, Koichiro Niwa, Shigeko Hara, Carlos A. Roncal-Jimenez, Petter Bjornstad, Takahiko Nakagawa, Ana Andres-Hernando, Yuka Sato, Thomas Jensen, Gabriela Garcia, Bernardo Rodriguez-Iturbe, Minoru Ohno, Miguel A. Lanaspa, Rich Tags: Cardiovascular Disease, Epidemiology, Risk Factors, High Blood Pressure, Hypertension Original Articles Source Type: research

Day-by-Day Variability of Home Blood Pressure and Incident Cardiovascular Disease in Clinical PracticeNovelty and Significance Blood Pressure Variability
We assessed the relationship between day-by-day home blood pressure (BP) variability and incident cardiovascular disease (CVD) in clinical practice. J-HOP study (Japan Morning Surge-Home Blood Pressure) participants underwent home BP monitoring in the morning and evening for a 14-day period, and their BP levels and BP variability independent of the mean (VIM) were assessed. Incident CVD events included coronary heart disease and stroke. Cox models were fitted to assess the home BP variability–CVD risk association. Among 4231 participants (mean±SD age, 64.9±10.9 years; 53.3% women; 79.1% taking antihypertensive medicati...
Source: Hypertension - December 13, 2017 Category: Cardiology Authors: Satoshi Hoshide, Yuichiro Yano, Hiroyuki Mizuno, Hiroshi Kanegae, Kazuomi Kario Tags: Hypertension Original Articles Source Type: research

Abstract P146: Uric Acid is an Independent Risk Factor for Developing Hypertension From Prehypertension: A 5-year Japanese Cohort Study Session Title: Onsite Poster Competition I With Reception
This study is conducted to clarify the risks.Methods: We conducted a retrospective 5-year cohort study using the data from 3,584 prehypertensive Japanese adults (52.1±11.0 years, 2,081 men) in 2004 and reevaluated it 5 years later. We calculated the cumulative incidences of hypertension over 5 years, then, we detected the risk factors and calculated odds ratios (ORs) for developing hypertension by crude analysis and after adjustments for age, sex, body mass index, smoking and drinking habits, baseline systolic and diastolic blood pressure, pulse rate, diabetes mellitus, dyslipidemia, chronic kidney disease, and serum uric...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Masanari Kuwabara, Shigeko Hara, Koichiro Niwa, Minoru Ohno, Ichiro Hisatome Tags: Poster Abstract Presentations Source Type: research

Abstract P451: Cerebrovasuclular Events in Patients With Primary Aldosteronism: Results of the PA Sendai Study Registry Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Background: Hyperaldosteronism is associated with the risk of cardio-and cerebrovascular events (CVE) that is independent of blood pressure levels and Primary aldosteronism (PA) display a higher risk of CVE compared with essential hypertension (EH).Objective: Our objective was to elucidate the prevalence of symptomatic stroke in PA patients and to characterize their clinical features.Design and Setting: This was a retrospective cross-sectional single center study (PA Sendai Study registry) between 2007 and 2016 in Japan.Patient: 807 patients with PA were registered and analyzed. The all patients were performed adrenal veno...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Masataka Kudo, Ryo Morimoto, Syuji Mugikura, Yuta Tezuka, Kei Omata, Mashiro Nezu, Yasuhiro Igarashi, Kazumasa Seiji, Kei Takase, Sadayoshi Ito, Fumitoshi Satoh Tags: Poster Abstract Presentations Source Type: research

Abstract P351: Cornell Product in Electrocardiogram is More Strongly Related to LV Regional Wall Motion Than Sokolow-Lyon Voltage Session Title: Cardiac Hypertrophy and Dysfunction and Coronary Artery Disease and Hypertension
Backgrounds: Left ventricular hypertrophy (LVH) evaluated by Cornell product in electrocardiogram predicted future stroke events greater than LVH by Sokolow-Lyon voltage. Therefore, we evaluated whether Cornell product was related to regional myocardial wall motion greater than Sokolow-Lyon voltage.Methods: We enrolled 288 hypertensive patients who were performed echocardiography for evaluating target organ damage. Cornell product was calculated as follows; R in aVL lead + S in V3 lead (0.6 mV added in female)хQRS duration; Sokolow-Lyon voltage, R in V5 lead + S in lead V1. We evaluated left ventricular mass index (LVMI),...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Joji Ishikawa, Yuko Yamanaka, Shintaro Watanabe, Kazumasa Harada Tags: Poster Abstract Presentations Source Type: research

Combined Effect of Blood Pressure and Total Cholesterol Levels on Long-Term Risks of Subtypes of Cardiovascular Death: Evidence for Cardiovascular Prevention From Observational Cohorts in Japan Epidemiology/Population
No large-scale, longitudinal studies have examined the combined effects of blood pressure (BP) and total cholesterol levels on long-term risks for subtypes of cardiovascular death in an Asian population. To investigate these relationships, a meta-analysis of individual participant data, which included 73 916 Japanese subjects (age, 57.7 years; men, 41.1%) from 11 cohorts, was conducted. During a mean follow-up of 15.0 years, deaths from coronary heart disease, ischemic stroke, and intraparenchymal hemorrhage occurred in 770, 724, and 345 cases, respectively. Cohort-stratified Cox proportional hazard models were used. After...
Source: Hypertension - February 11, 2015 Category: Cardiology Authors: Satoh, M., Ohkubo, T., Asayama, K., Murakami, Y., Sakurai, M., Nakagawa, H., Iso, H., Okayama, A., Miura, K., Imai, Y., Ueshima, H., Okamura, T., on behalf of the Evidence for Cardiovascular Prevention From Observational Cohorts in Japan (EPOCH-JAPAN) Res Tags: Lipids, Epidemiology Epidemiology/Population Source Type: research

Cardiovascular Risk With and Without Antihypertensive Drug Treatment in the Japanese General Population: Participant-Level Meta-Analysis Epidemiology/Population
To evaluate the cardiovascular mortality risk in association with blood pressure level among people with and without antihypertensive treatment, we performed the participant-level meta-analysis that included 39 705 Japanese from 6 cohorts (58.4% women; mean age, 60.1 years; 20.4% treated). Multivariable-adjusted Cox models were used to analyze the risk of cardiovascular mortality and its subtypes among 6 blood pressure levels according to recent guidelines, optimal to Grade 3 hypertension, and the usage of antihypertensive medication at baseline. During median 10.0 years of follow-up, there were 2032 cardiovascular deaths ...
Source: Hypertension - May 7, 2014 Category: Cardiology Authors: Asayama, K., Satoh, M., Murakami, Y., Ohkubo, T., Nagasawa, S.-y., Tsuji, I., Nakayama, T., Okayama, A., Miura, K., Imai, Y., Ueshima, H., Okamura, T., on behalf of the Evidence for Cardiovascular Prevention From Observational Cohorts in Japan (EPOCH-JAPA Tags: Epidemiology Epidemiology/Population Source Type: research