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Lower 25-hydroxyvitamin D is associated with severer white matter hyperintensity and cognitive function in patients with non-disabling ischemic cerebrovascular events
Vascular cognitive impairment (VCI) is the second most common type of cognitive impairment, referring to the entire spectrum of cognitive impairment contributed by cerebrovascular pathology1. Due to the progressively higher incidence of stroke and cerebrovascular diseases, VCI, including post-stroke cognitive impairment are the leading causes of disability epidemic worldwide2-3. White matter lesions, manifested as white matter hyperintensities (WMH) on T2-weighted magnetic resonance imaging (MRI) scans, are one of the most common pathological characteristics of VCI4.
Source: Journal of Stroke and Cerebrovascular Diseases - August 31, 2023 Category: Neurology Authors: Zhengsheng Gu, Xu Sun, Chenghao Wu, Binghan Li, Jingjing Chen, Weisen Wang, Xin Gao, Yuhao Tan, Bin Li, Ge Yin, Yawen Xu, Chenrui Song, Bingying Du, Xiaoying Bi Source Type: research

Post-stroke pneumonia: Factors associated with readmission within 90 days of stroke discharge
Stroke is the fifth leading cause of death and a leading cause of disability within the United States.1,2 On average, a stroke occurs every 40 seconds and accounts for approximately 1 in every 19 deaths.2 The prevalence of stroke is projected to increase by 20.5% from 2012 to 2030.2 Post-stroke complications are prevalent; infection occurs among 30% of acute cases.3 Pneumonia is one of the most common post-stroke infections and is associated with increased morbidity.4,5 Moreover, pneumonia is recognized as an independent risk factor for stroke-related mortality.
Source: Journal of Stroke and Cerebrovascular Diseases - August 21, 2023 Category: Neurology Authors: Tiffany Bouddhara, LeighAnn Persondek, Elizabeth Ablah, Hayrettin Okut, Liuqiang Lu, James Walker Source Type: research

Risk of suicide among stroke survivors in the United States
Stroke is the largest cause of disability and the 5th leading cause of death in the United States. Suicide is the 12th leading cause of death in the United States. However, little is known about the risk of suicide among people with a prior stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - August 19, 2023 Category: Neurology Authors: Ben Grobman, Neeharika Kothapalli, Arian Mansur, Christine Y Lu Source Type: research

Importance of microRNAs by mRNA-microRNA integration analysis in acute ischemic stroke patients
Acute ischemic stroke is common, and severe forms of the condition are becoming notably widespread due to the aging population.1 Patients with severe ischemic stroke are at high risk of mortality or disability due to neurological deficits, requiring long-term care; neurological deficits are typically associated with increased medical costs.1, 2 Recently, the treatment of severe hyperacute ischemic stroke has been established due to the introduction of recombinant tissue plasminogen activators3,4 and endovascular treatment,5 –7 but only selected population can benefit from these treatments.
Source: Journal of Stroke and Cerebrovascular Diseases - August 8, 2023 Category: Neurology Authors: Hideaki Kanki, Hisatake Matsumoto, Yuki Togami, Daisuke Okuzaki, Hiroshi Ogura, Tsutomu Sasaki, Hideki Mochizuki Source Type: research

Association of underlying untreated cardiovascular risk factors with mortality and functional outcome in ischaemic stroke patients
Stroke is the third leading cause of death after ischaemic heart disease (IHD) and pneumonia in Malaysia.1 Aziz et al. reported that Malaysia's prevalence of ischaemic stroke had increased from 42.8 to 118.7 in 100,000 from 2010 to 2014. The report showed that 8-11% of ischaemic stroke patients died within 30 days while 56-61% survived with significant disability in Malaysia.2 Our previous study showed that patients with ischaemic stroke in Malaysia were younger, but the mortality rate was higher than in other countries.
Source: Journal of Stroke and Cerebrovascular Diseases - July 19, 2023 Category: Neurology Authors: Teck Long King, Lee Len Tiong, Zariah Abdul  Aziz, Wan Chung Law Source Type: research

Relative contributions of positive, negative, and adaptive features to limitations in upper-limb function three months after stroke
Stroke is the second leading cause of disability and death around the world, representing an immense burden for the individuals1. In 2010, the estimated incidence of stroke worldwide was 16.9 million, with the majority occurring in low- and middle-income countries1. In 2016, the number of new stroke cases was 13.7 million, with 5.5 million deaths worldwide attributable to stroke2.
Source: Journal of Stroke and Cerebrovascular Diseases - July 18, 2023 Category: Neurology Authors: Christine VO Matozinho, Patrick R Avelino, Christina Danielli Coelho de Morais Faria, Luci F Teixeira-Salmela, K ênia KP de Menezes, Romeu Sant'Anna, Aline Alvim Scianni Source Type: research

Effect of race/ethnicity on arterial recanalization following intravenous thrombolysis in acute ischemic stroke patients
Several reports have identified that clinical outcomes such as death or disability in acute ischemic stroke (AIS) patients following intravenous (IV) tissue plasminogen activator (tPA) treatment can vary according to race and ethnicities. We determined the effect of race/ethnicity on rates of arterial recanalization in AIS patients with large vessel occlusion (LVO) after IV tPA.
Source: Journal of Stroke and Cerebrovascular Diseases - July 13, 2023 Category: Neurology Authors: Rami Fakih, Xiaoyu Ma, Abdullah Lodhi, Navpreet Bains, Brandi R. French, Farhan Siddiq, Camilo R. Gomez, Adnan I. Qureshi Source Type: research

Factors related to unfavorable outcome in minor ischemic stroke
Stroke recurrence and disability are important challenges to overcome in patients with minor ischemic stroke. The aim of our study was to determine the factors associated with unfavorable outcomes in patients with minor ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - July 11, 2023 Category: Neurology Authors: Mai Duy Ton, Dao Viet Phuong, Vu Thi Thom, Nguyen Tien Dung, Pham Quang Tho, Le Duc Thuan, Thanh N. Nguyen Source Type: research

Bone marrow mesenchymal stem cell-derived exosomal miR-193b-5p reduces pyroptosis after ischemic stroke by targeting AIM2
Ischemic stroke is a frequently occurring cerebrovascular disease (CVD) linked to high mortality, disability, and incidence rates, and the second factor causing global mortality41,3. There are two common sources of embolism in ischamic strokes: large artery atherosclerosis and small artery atherosclerosis. Ischemic stroke can be treated clinically with thrombolytic therapy4. Although ischemic stroke is treatable, post-cerebral ischemia blood reperfusion frequently induces inflammation, oxidative stress (OS) or additional unfavorable events that may exacerbate brain injury20,24.
Source: Journal of Stroke and Cerebrovascular Diseases - June 30, 2023 Category: Neurology Authors: Yingju Wang, Hongping Chen, Xuehui Fan, Chen Xu, Meng Li, Hongxue Sun, Jihe Song, Feihong Jia, Wan Wei, Fangchao Jiang, Guozhong Li, Di Zhong Source Type: research

Hospital Discharge and Readmissions Before and During the COVID-19 Pandemic for California Acute Stroke Inpatients
Stroke is a leading cause of death and disability in the United States, with approximately 795,000 new strokes occurring annually, including acute ischemic stroke (AIS), intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH).1 The Coronavirus Disease 2019 (COVID-19) pandemic has impacted all levels of care for stroke patients, such as delays in initial presentation, reduction in acute therapies, limitations of in-patient resources, delays or lack of initiation of secondary stroke prevention therapy, and limitations in rehabilitation services after hospital discharge.
Source: Journal of Stroke and Cerebrovascular Diseases - June 23, 2023 Category: Neurology Authors: George P. Albert, Daryl C. McHugh, Debra E. Roberts, Adam G. Kelly, Remi Okwechime, Robert G. Holloway, Benjamin P. George Source Type: research

Difference in acute and chronic stage ischemic stroke metabolic markers with controls
Acute Ischemic Stroke (AIS), a major cause of disability, was previously associated with multiple metabolomic changes, but many findings were contradictory. Case-control and longitudinal study designs could have played a role in that. To clarify metabolomic changes, we performed a simultaneous comparison of ischemic stroke metabolome in acute, chronic stages of stroke and controls.
Source: Journal of Stroke and Cerebrovascular Diseases - June 16, 2023 Category: Neurology Authors: Evgeny V. Sidorov, Madhusmita Rout, Chao Xu, Larsen Jordan, Evan Fields, Blair Apple, Kyle Smith, David Gordon, Juliane Chainakul, Dharambir K. Sanghera Source Type: research

Autonomic function may mediate the neuroprotection of remote ischemic postconditioning in stroke: A randomized controlled trial
Acute ischemic stroke(AIS) is one of the leading causes of death and long-lasting disability on a global level, with an increased global burden in the past two decades.1,2 Early restoration of blood flow is currently recognized as the most effective therapy for AIS. However, rapid reperfusion after a certain period of ischemia could paradoxically induce ischemia-perfusion injury (IRI), which can promote neurovascular inflammation by inducing the generation of cytokines, and thus aggravate stroke severity and adverse neurological outcomes.
Source: Journal of Stroke and Cerebrovascular Diseases - June 15, 2023 Category: Neurology Authors: Hao Liang, Richun Ye, Xiaopei Zhang, Huanwen Ye, Wenwei Ouyang, Shuang Cai, Lin Wei Source Type: research

Klotho gene might antagonize ischemic injury in stroke rats by reducing the expression of AQP4 via P38MAPK pathway
Epidemiological studies have shown that ischemic stroke (IS) is a disease with high morbidity, disability, and mortality. Approximately 16.9 million people suffer from IS, and 2.7 million die from this disease each year worldwide; 50% of survivors are disabled, putting a heavy financial burden on patients' families and society.1 Ischemic stroke is caused by a series of harmful signal cascade reactions triggered by a sudden interruption of blood supply to brain tissue, resulting in irreversible brain tissue damage and neurological impairments.
Source: Journal of Stroke and Cerebrovascular Diseases - June 6, 2023 Category: Neurology Authors: Guanghua Zhu, Tao Xiang, Shengjiao Liang, Kai Liu, Zijian Xiao, Qing Ye Source Type: research

Risk assessment of mechanic thrombectomy on post-stroke seizures: a systematical review and meta-analysis
Acute ischemic stroke is a leading cause of disability, with over a third of survivors developing new post-stroke disabilities around the world.1 Many post-stroke patients have a significant higher risk of developing post-stroke seizures of which the incidence has also been increasing over the past decades.2 Cerebrovascular disease is the leading cause of seizures in adults over 60-year-old, which has been shown to account for nearly 50% of newly diagnosed epilepsy in this age group.3
Source: Journal of Stroke and Cerebrovascular Diseases - May 10, 2023 Category: Neurology Authors: Wen Jiang, Xiaoyan Zhu, Chunyan Lei, Guoliang Jiang, Linming Zhang, Song Mei, Lianmei Zhong Source Type: research

Social and health determinants related to adverse short-term outcomes after a first-ever stroke in adults younger than 65 years
Stroke-related mortality and disability-adjusted life years in adults younger than 65 have increased over the last decade. However, geographical differences in distributing these outcomes could reflect dissimilarity in determinants. Therefore, this cross-sectional study of secondary data from Chilean hospitals aims to analyze the association of sociodemographic and clinical factors with in-hospital case-fatality risk or acquired neurologic deficits (adverse outcomes) in inpatients aged 18 to 64 who experienced their first-ever stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - May 10, 2023 Category: Neurology Authors: Mauricio Lopez-Espejo, Rodrigo Poblete, Gabriel Bastias Source Type: research

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