Klotho gene might antagonize ischemic injury in stroke rats by reducing the expression of AQP4 via P38MAPK pathway

Epidemiological studies have shown that ischemic stroke (IS) is a disease with high morbidity, disability, and mortality. Approximately 16.9 million people suffer from IS, and 2.7 million die from this disease each year worldwide; 50% of survivors are disabled, putting a heavy financial burden on patients' families and society.1 Ischemic stroke is caused by a series of harmful signal cascade reactions triggered by a sudden interruption of blood supply to brain tissue, resulting in irreversible brain tissue damage and neurological impairments.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research