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Interventions for the uptake of evidence-based recommendations in acute stroke settings
CONCLUSIONS: We are uncertain whether a multifaceted implementation intervention compared to no intervention improves adherence to evidence-based recommendations in acute stroke settings, because the certainty of evidence is very low.PMID:37565934 | PMC:PMC10416310 | DOI:10.1002/14651858.CD012520.pub2
Source: Cochrane Database of Systematic Reviews - August 11, 2023 Category: General Medicine Authors: Elizabeth A Lynch Lemma N Bulto Heilok Cheng Louise Craig Julie A Luker Kathleen L Bagot Tharshanah Thayabaranathan Heidi Janssen Elizabeth McInnes Sandy Middleton Dominique A Cadilhac Source Type: research

Peroxisome proliferator-activated receptor gamma agonists for preventing recurrent stroke and other vascular events in people with stroke or transient ischaemic attack
CONCLUSIONS: Peroxisome proliferator-activated receptor gamma agonists probably reduce recurrent stroke and total events of cardiovascular death, non-fatal myocardial infarction or non-fatal stroke, and may improve insulin sensitivity and the stabilisation of carotid plaques. Their effects on adverse events are uncertain. Our conclusions should be interpreted with caution considering the small number and the quality of the included studies. Further well-designed, double-blind RCTs with large samples are required to assess the efficacy and safety of PPAR-γ agonists in the secondary prevention of stroke and related vascular...
Source: Cochrane Database of Systematic Reviews - January 10, 2023 Category: General Medicine Authors: Jia Liu Lu-Ning Wang Source Type: research

Surgical decompression for malignant cerebral oedema after ischaemic stroke
CONCLUSIONS: Surgical decompression improves outcomes in the management of malignant oedema after acute ischaemic stroke, including a considerable reduction in death or severe disability (mRS > 4) and a reduction in death or moderate disability (mRS > 3). Whilst there is evidence that this positive treatment effect is present in patients > 60 years old, it is important to take into account that these patients have a poorer prospect of functional survival independent of this treatment effect. In interpreting these results it must also be considered that the data demonstrating benefit are drawn from a unique patient...
Source: Cochrane Database of Systematic Reviews - November 17, 2022 Category: General Medicine Authors: Ashraf Dower Michael Mulcahy Monish Maharaj Hui Chen Chi Eung Danforn Lim Yingda Li Mark Sheridan Source Type: research

Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage
CONCLUSIONS: The current evidence does not support the routine use of antifibrinolytic drugs in the treatment of people with aneurysmal subarachnoid haemorrhage. More specifically, early administration with concomitant treatment strategies to prevent delayed cerebral ischaemia does not improve clinical outcome. There is sufficient evidence from multiple randomised controlled trials to incorporate this conclusion in treatment guidelines.PMID:36350005 | DOI:10.1002/14651858.CD001245.pub3
Source: Cochrane Database of Systematic Reviews - November 9, 2022 Category: General Medicine Authors: Menno R Germans Wouter J Dronkers Merih I Baharoglu Ren é Post Dagmar Verbaan Gabriel Je Rinkel Yvo Bwem Roos Source Type: research

Repetitive peripheral magnetic stimulation for impairment and disability in people after stroke
CONCLUSIONS: There is insufficient evidence to permit the drawing of any conclusions about routine use of rPMS for people after stroke. Additional trials with large sample sizes are needed to provide robust evidence for rPMS after stroke.PMID:36169558 | PMC:PMC9518012 | DOI:10.1002/14651858.CD011968.pub4
Source: Cochrane Database of Systematic Reviews - September 28, 2022 Category: General Medicine Authors: Tomohiko Kamo Yoshitaka Wada Masatsugu Okamura Kotomi Sakai Ryo Momosaki Shunsuke Taito Source Type: research

Effects of a gluten-reduced or gluten-free diet for the primary prevention of cardiovascular disease
CONCLUSIONS: Very low-certainty evidence suggested that it is unclear whether gluten intake is associated with all-cause mortality. Our findings also indicate that low-certainty evidence may show little or no association between gluten intake and cardiovascular mortality and non-fatal myocardial infarction. Low-certainty evidence suggested that a lower compared with a higher gluten intake may be associated with a slightly increased risk to develop type 2 diabetes - a major cardiovascular risk factor. For other cardiovascular risk factors it is unclear whether there is a difference between a gluten-free and normal diet. Giv...
Source: Cochrane Database of Systematic Reviews - February 24, 2022 Category: General Medicine Authors: Christine Schmucker Angelika Eisele-Metzger Joerg J Meerpohl Cornelius Lehane Daniela Kuellenberg de Gaudry Szimonetta Lohner Lukas Schwingshackl Source Type: research

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