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Regulation of endothelial function by cigarette smoke and next-generation tobacco and nicotine products
Pflugers Arch. 2023 Jun 7. doi: 10.1007/s00424-023-02824-w. Online ahead of print.ABSTRACTCigarette smoking is the most important avoidable cardiovascular risk factor. It causes endothelial dysfunction and atherosclerosis and increases the risk of its severe clinical complications like coronary artery disease, myocardial infarction, stroke, and peripheral artery disease. Several next-generation tobacco and nicotine products have been developed to decrease some of the deleterious effects of regular tobacco smoking. This review article summarizes recent findings about the impact of cigarette smoking and next-generation tobac...
Source: Pflugers Archiv : European Journal of Physiology - June 7, 2023 Category: Physiology Authors: Justus Klein Patrick Diaba-Nuhoho Sindy Giebe Coy Brunssen Henning Morawietz Source Type: research

Triclosan is a KCNQ3 potassium channel activator
Pflugers Arch. 2022 Apr 22. doi: 10.1007/s00424-022-02692-w. Online ahead of print.ABSTRACTKCNQ channels participate in the physiology of several cell types. In neurons of the central nervous system, the primary subunits are KCNQ2, 3, and 5. Activation of these channels silence the neurons, limiting action potential duration and preventing high-frequency action potential burst. Loss-of-function mutations of the KCNQ channels are associated with a wide spectrum of phenotypes characterized by hyperexcitability. Hence, pharmacological activation of these channels is an attractive strategy to treat epilepsy and other hyperexci...
Source: Pflugers Archiv : European Journal of Physiology - April 23, 2022 Category: Physiology Authors: Victor De la Rosa Maria Luisa Guzm án-Hernández Elisa Carrillo Source Type: research

MiR-10b-3p alleviates cerebral ischemia/reperfusion injury by targeting Kr üppel-like factor 5 (KLF5)
Pflugers Arch. 2022 Jan 6. doi: 10.1007/s00424-021-02645-9. Online ahead of print.ABSTRACTAlthough miR-10b-3p has been identified to be involved in cerebral ischemia injury, its impact and specific mechanism in cerebral ischemia injury remain unclear. The effects of Mir-10b-3p were investigated by establishing rat and cell models of ischemia/reperfusion (I/R) injury. Oxygen-glucose deprivation/reperfusion (OGD/R) was performed on pheochromocytoma-12 (PC12) cells. MiR-10b-3p expression levels in brain tissues and PC12 cells were detected by qRT-PCR. The impacts of miR-10b-3p on neurological deficits, infarct volume, inflamm...
Source: Pflugers Archiv : European Journal of Physiology - January 6, 2022 Category: Physiology Authors: Ke Sun Jiangang Zhang Qingcheng Yang Jinzhao Zhu Xiangdong Zhang Kun Wu Zhenhua Li Weizheng Xie Xue Luo Source Type: research

Relevance of stromal interaction molecule 1 (STIM1) in experimental and human stroke
Pflugers Arch. 2021 Nov 10. doi: 10.1007/s00424-021-02636-w. Online ahead of print.ABSTRACTStroke represents a main cause of death and permanent disability worldwide. In the attempt to develop targeted preventive and therapeutic strategies, several efforts were performed over the last decades to identify the specific molecular abnormalities preceding cerebral ischemia and neuronal death. In this regard, mitochondrial dysfunction, autophagy, and intracellular calcium homeostasis appear important contributors to stroke development, as underscored by recent pre-clinical evidence. Intracellular calcium (Ca2+) homeostasis is re...
Source: Pflugers Archiv : European Journal of Physiology - November 10, 2021 Category: Physiology Authors: Rosita Stanzione Maurizio Forte Maria Cotugno Franca Bianchi Simona Marchitti Speranza Rubattu Source Type: research

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