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Source: CNS Neuroscience and Therapeutics

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Total 476 results found since Jan 2013.

Recent advances and perspectives of postoperative neurological disorders in the elderly surgical patients
CNS Neurosci Ther. 2021 Dec 3. doi: 10.1111/cns.13763. Online ahead of print.ABSTRACTPostoperative neurological disorders, including postoperative delirium (POD), postoperative cognitive dysfunction (POCD), postoperative covert ischemic stroke, and hemorrhagic stroke, are challenging clinical problems in the emerging aged surgical population. These disorders can deteriorate functional outcomes and long-term quality of life after surgery, resulting in a substantial social and financial burden to the family and society. Understanding predisposing and precipitating factors may promote individualized preventive treatment for e...
Source: CNS Neuroscience and Therapeutics - December 4, 2021 Category: Neuroscience Authors: Biying Liu Dan Huang Yunlu Guo Xiaoqiong Sun Caiyang Chen Xiaozhu Zhai Xia Jin Hui Zhu Peiying Li Weifeng Yu Source Type: research

Does variability in automated perfusion software outputs for acute ischemic stroke matter? Reanalysis of EXTEND perfusion imaging
CONCLUSIONS: These data reinforce the benefit of alteplase in the later time window, and suggest that differences in automated perfusion imaging software outputs may be clinically relevant.PMID:34786868 | DOI:10.1111/cns.13756
Source: CNS Neuroscience and Therapeutics - November 17, 2021 Category: Neuroscience Authors: Andrew Bivard Leonid Churilov Henry Ma Christopher Levi Bruce Campbell Nawaf Yassi Atte Meretoja Henry Zhao Gagan Sharma Chushuang Chen Stephen Davis Geoffrey Donnan Bernard Yan Mark Parsons EXTEND investigators Source Type: research

Predictive value of different bilirubin subtypes for clinical outcomes in patients with acute ischemic stroke receiving thrombolysis therapy
CONCLUSION: Increased DBIL pre-thrombolysis had a stronger association with, as well as greater incremental predictive value for, poor outcomes than TBIL and IBIL did in AIS patients after thrombolysis, which should be understood in the context of retrospective design. The effect of DBIL on targeted populations should be investigated in further researches.PMID:34779141 | DOI:10.1111/cns.13759
Source: CNS Neuroscience and Therapeutics - November 15, 2021 Category: Neuroscience Authors: Qiwei Peng Rentang Bi Shengcai Chen Jiefang Chen Zhifang Li Jianzhuang Li Huijuan Jin Bo Hu Source Type: research

Effect of Ginkgolide in Ischemic Stroke patients with large Artery Atherosclerosis: Results from a randomized trial
CONCLUSIONS: Ginkgolide, working as PAF antagonist, may reduce recurrent stroke in AIS with ICAS patients within 72 hours after onset. It might be an optional treatment in moderate-to-severe AIS patients with ICAS. (http://www.chictr.org.cn Number as ChiCTR-IPR-17012310).PMID:34676982 | DOI:10.1111/cns.13742
Source: CNS Neuroscience and Therapeutics - October 22, 2021 Category: Neuroscience Authors: Yi Dong Jingyu Zhang Yanxia Wang Lihong Zhao Runhui Li Chunhua Wei Qingke Bai Lishu Wan Liping Sun Shejun Feng Mingyao You Chun Wang Hongtian Zhang Qing He Ming Yu Qiang Dong GISAA committee Source Type: research

Imperatorin inhibits mitogen-activated protein kinase and nuclear factor kappa-B signaling pathways and alleviates neuroinflammation in ischemic stroke
CONCLUSIONS: Imperatorin downregulated MAPK and NF-κB signaling pathways and exerted anti-inflammatory effects in ischemic stroke, which indicated that imperatorin might be a potential compound for the treatment of stroke.PMID:34674376 | DOI:10.1111/cns.13748
Source: CNS Neuroscience and Therapeutics - October 21, 2021 Category: Neuroscience Authors: Jian-Wei Ge Shi-Ji Deng Zhi-Wei Xue Pin-Yi Liu Lin-Jie Yu Jiang-Nan Li Sheng-Nan Xia Yue Gu Xin-Yu Bao Zhen Lan Yun Xu Xiao-Lei Zhu Source Type: research

Alterations in the gut microbiome with hemorrhagic transformation in experimental stroke
CONCLUSION: This study provides important information about the gut microbiota profiles and SCFA levels of MCAO rats with HT or non-HT. The susceptibility to HT in MCAO rats is associated with inflammation and gut microbiota modulation.PMID:34591349 | DOI:10.1111/cns.13736
Source: CNS Neuroscience and Therapeutics - September 30, 2021 Category: Neuroscience Authors: Qin Huang Liao Di Fang Yu Xianjing Feng Zeyu Liu Minping Wei Yunfang Luo Jian Xia Source Type: research

Morinda officinalis oligosaccharides alleviate depressive-like behaviors in post-stroke rats via suppressing NLRP3 inflammasome to inhibit hippocampal inflammation
CONCLUSION: Overall, our study reveals the antidepressive effect of MOOs on PSD rats through modulation of microglial NLRP3 inflammasome. We also provide a novel insight into hippocampal inflammation response in PSD pathology and put forward NLRP3 inflammasome as a potential therapeutic target for PSD.PMID:34559953 | DOI:10.1111/cns.13732
Source: CNS Neuroscience and Therapeutics - September 24, 2021 Category: Neuroscience Authors: Zhifang Li Hexiang Xu Yi Xu Guanfeng Lu Qiwei Peng Jiefang Chen Rentang Bi Jianzhuang Li Shengcai Chen Hongkai Li Huijuan Jin Bo Hu Source Type: research

Identification of embolic stroke in patients with large vessel occlusion: The Chinese embolic stroke score, CHESS
CONCLUSION: CHESS could reliably and independently identify embolic stroke as the cause of large vessel occlusion.PMID:34559949 | DOI:10.1111/cns.13729
Source: CNS Neuroscience and Therapeutics - September 24, 2021 Category: Neuroscience Authors: Lan Hong Longting Lin Gang Li Jianhong Yang Yu Geng Min Lou Mark Parsons Xin Cheng Qiang Dong Source Type: research

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