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Source: CNS Neuroscience and Therapeutics
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Total 476 results found since Jan 2013.
Potential nanotherapeutic strategies for perioperative stroke
CONCLUSION: In this review, the pathological processes and mechanisms of ischemic stroke during perioperative stroke onset were systematically sorted. As a potential treatment strategy for perioperative stroke, the review also summarizes the multifunctional nanodelivery systems based on ischemic stroke, thus providing insight into the nanotherapeutic strategies for perioperative stroke.PMID:35243774 | DOI:10.1111/cns.13819
Source: CNS Neuroscience and Therapeutics - March 4, 2022 Category: Neuroscience Authors: Jingyi An Ling Zhao Ranran Duan Ke Sun Wenxin Lu Jiali Yang Yan Liang Junjie Liu Zhenzhong Zhang Li Li Jinjin Shi Source Type: research
Dysphagia screening and pneumonia after subarachnoid hemorrhage: Findings from the Chinese stroke center alliance
CONCLUSION: More than a quarter of patients with SAH did not have documented DS, while one-fifth developed pneumonia. DS performance was associated with a lower risk of pneumonia. Randomized controlled trials may be needed to determine the effectiveness of DS.PMID:35233938 | DOI:10.1111/cns.13822
Source: CNS Neuroscience and Therapeutics - March 2, 2022 Category: Neuroscience Authors: Mei-Ru Wu Yi-Tong Chen Zi-Xiao Li Hong-Qiu Gu Kai-Xuan Yang Yun-Yun Xiong Yong-Jun Wang Chun-Juan Wang Source Type: research
Perioperative stroke: A perspective on challenges and opportunities for experimental treatment and diagnostic strategies
CNS Neurosci Ther. 2022 Feb 27. doi: 10.1111/cns.13816. Online ahead of print.ABSTRACTPerioperative stroke is an ischemic or hemorrhagic cerebral event during or up to 30 days after surgery. It is a feared condition due to a relatively high incidence, difficulties in timely detection, and unfavorable outcome compared to spontaneously occurring stroke. Recent preclinical data suggest that specific pathophysiological mechanisms such as aggravated neuroinflammation contribute to the detrimental impact of perioperative stroke. Conventional treatment options are limited in the perioperative setting due to difficult diagnosis an...
Source: CNS Neuroscience and Therapeutics - February 28, 2022 Category: Neuroscience Authors: Xia Jin Peiying Li Dominik Michalski Shen Li Yueman Zhang Jukka Jolkkonen Lili Cui Nadine Didwischus Wei Xuan Johannes Boltze Source Type: research
Progranulin promotes hippocampal neurogenesis and alleviates anxiety-like behavior and cognitive impairment in adult mice subjected to cerebral ischemia
CONCLUSIONS: Progranulin alleviates ischemia-induced anxiety-like behavior and spatial learning and memory impairment in mice, probably via stimulation of hippocampal neurogenesis mediated by activation of MAPK/ERK and PI3K/Akt pathways. PGRN might be a promising candidate for coping with ischemic stroke-induced mood and cognitive impairment in clinic.PMID:35146924 | DOI:10.1111/cns.13810
Source: CNS Neuroscience and Therapeutics - February 11, 2022 Category: Neuroscience Authors: Siqi Sun Jinlong Zhou Zhongqi Li Yuzi Wu Hao Wang Qi Zheng Frank Adu-Nti Juan Fan Yingfang Tian Source Type: research
Recent highlights in periopeative neurological disorders, from bench to bedside
CNS Neurosci Ther. 2022 Feb 11. doi: 10.1111/cns.13771. Online ahead of print.ABSTRACTPerioperative neurological disorders are important causes of postoperative disability and even perioperative death, bringing a huge challenge to the vulnerable and increasing aging population. Perioperative neurological disorders usually contain ischemic stroke, hemorrhagic stroke, and neurocognitive disorders during the perioperative period. Although a few prevention and treatment strategies have been developed for each disorder, there is still a lack of effective treatments and the underlying mechanisms are far from well-understood. Thi...
Source: CNS Neuroscience and Therapeutics - February 11, 2022 Category: Neuroscience Authors: Yunlu Guo Peiying Li Source Type: research
