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Total 229 results found since Jan 2013.

Protocols and Guidelines for Stroke in Children: Point and Counterpoint
Cerebrovascular diseases carry a heavy burden of disease in children with consequences that last a lifetime.1 Perinatal stroke causes most hemiparetic cerebral palsy with additional nonmotor consequences affecting diverse aspects of development and quality of life.2 Stroke during childhood is also associated with broad neurodevelopmental disabilities and morbidity. Among a myriad of potential pathophysiologic mechanisms, few are directly treatable and prevention strategies are the exception rather than the rule.
Source: Pediatric Neurology - December 24, 2018 Category: Neurology Authors: Adam Kirton, Michael Dowling Tags: Opinion Paper Source Type: research

Hemorrhagic Transformation of Arterial Ischemic and Venous Stroke in Children
Hemorrhagic transformation can complicate both arterial ischemic stroke (AIS) and cerebral sinus venous thrombosis (CSVT). Risk factors for hemorrhagic transformation after adult AIS include larger infarct volume, cardioembolic stroke, and anticoagulation in the acute period. Large hemorrhagic transformation in adults is associated with poor outcome. Therefore, hemorrhagic transformation is used as a safety endpoint of most AIS acute treatment and secondary prevention trials. Up to 30% of children with AIS have hemorrhagic transformation, most of which is petechial.
Source: Pediatric Neurology - February 7, 2019 Category: Neurology Authors: Melissa L. Hutchinson, Lauren A. Beslow Tags: Topical Review Source Type: research

Stroke after cardiac catheterization in children
Children with cardiac disease are at high risk for stroke. Approximately one-quarter of strokes in children with cardiac disease occur in the peri-procedural period; yet, risk factors, clinical presentation, and treatment of post-catheterization stroke in children have not been well-defined.
Source: Pediatric Neurology - July 17, 2019 Category: Neurology Authors: Dana B. Harrar, Catherine L. Salussolia, Patrick Vittner, Amy Danehy, Sonali Sen, Robert Whitehill, Jessica H. Chao, Miya E. Bernson-Leung, Michael J. Rivkin Tags: Original Articles Source Type: research

A Stroke Mimic: anti-MOG antibody associated disorder presenting as acute hemiparesis
Demyelinating, inflammatory, and autoimmune conditions have been implicated as pediatric stroke mimics.1 Anti-myelin oligodendrocyte glycoprotein-Associated Disorders (MOG-AD) has not yet been identified as a pediatric stroke mimic. MOG-AD is a distinct entity with varying clinical demyelinating diseases due to anti-MOG antibodies (MOG-ab).2,3 Here we describe a patient who presented with acute onset hemiparesis and respiratory failure with positive MOG-ab.
Source: Pediatric Neurology - March 10, 2020 Category: Neurology Authors: Michelle S. Tutmaher, Denise F. Chen, Jamika Hallman-Cooper, Philip J. Holt, Bryan Philbrook, Grace Y. Gombolay Tags: Short Communication Source Type: research

A Stroke Mimic: Anti-MOG Antibody-Associated Disorder Presenting as Acute Hemiparesis
Demyelinating, inflammatory, and autoimmune conditions have been implicated as pediatric stroke mimics.1 Anti-myelin oligodendrocyte glycoprotein-associated disorder (MOG-AD) has not yet been identified as a pediatric stroke mimic. MOG-AD is a distinct entity with varying clinical demyelinating diseases due to anti-MOG antibodies (MOG-ab).2,3 Here we describe a patient who presented with acute-onset hemiparesis and respiratory failure with positive MOG-ab.
Source: Pediatric Neurology - March 10, 2020 Category: Neurology Authors: Michelle S. Tutmaher, Denise F. Chen, Jamika Hallman-Cooper, Philip J. Holt, Bryan Philbrook, Grace Y. Gombolay Tags: Clinical Letter Source Type: research

Defining a Pediatric Stroke Center
Stroke was once recognized so infrequently in children that it was considered a medical curiosity, and until relatively recently, our understanding of the nature of cerebrovascular disorders in children was somewhat rudimentary. But we now know that cerebrovascular disorders are relatively common among children,1 and with the advent of less invasive diagnostic studies and more targeted treatments, stroke is now recognized as a very important clinical condition in children.
Source: Pediatric Neurology - August 11, 2020 Category: Neurology Authors: E. Steve Roach, Timothy Bernard, M.D. Gabrielle deVeber Source Type: research

Acute ischemic stroke in a pediatric patient due to osteosarcoma embolus
We report a 6-year-old with an ischemic stroke due to osteosarcoma embolus.
Source: Pediatric Neurology - April 22, 2021 Category: Neurology Authors: Min Ye Shen, Amol Mehta, Rebecca J. Zylber, Alice Lee, Randolph S. Marshall, Arezou Heshmati Tags: Short Communication Source Type: research

Acute Ischemic Stroke in a Pediatric Patient due to Osteosarcoma Embolism
We report a six-year-old with an ischemic stroke due to osteosarcoma embolism.
Source: Pediatric Neurology - April 22, 2021 Category: Neurology Authors: Min Ye Shen, Amol Mehta, Rebecca J. Zylber, Alice Lee, Randolph S. Marshall, Arezou Heshmati Tags: Clinical Letter Source Type: research

Capacity Building for Primary Stroke Prevention Teams in Children Living with Sickle Cell Anemia in Africa
We describe capacity-building strategies in conjunction with two National Institutes of Health-funded primary stroke prevention trials (a feasibility trial and phase III randomized controlled trial) with initial hydroxyurea treatment for children with SCA and abnormal transcranial Doppler (TCD) velocities in Nigeria.
Source: Pediatric Neurology - September 3, 2021 Category: Neurology Authors: Djamila L. Ghafuri, Brittany Covert Greene, Bilya Musa, Awwal Gambo, Abdulrasheed Sani, Shehu Abdullahi, Binta J. Widil, Halima Bello-Manga, Safiya Gambo, Matin Ghafuri, Holly Cassell, Kathleen Neville, Fenella Kirkham, Adetola A. Kassim, Muktar H. Aliyu, Tags: Research Paper Source Type: research

Inherited thrombophilia associated with ischemic pediatric stroke in parents-child pairs
We aimed to examine inherited thrombophilia frequencies by extending genetic profile to previously rarely or not-investigated polymorphisms, in children with ischemic pediatric stroke (IPS) and their parents.The study included 33 children: 23 with perinatal (PAIS), 8 with childhood arterial ischemic stroke (CAIS) and 2 with sinovenous thrombosis (SVT) and their parents (33 mother-child, 12 father-child and 12 mother-father-child pairs). Genotyping of FV-Leiden, FV-H1299R, FII-G20210A, β-fibrinogen-455G>A, FXIII-A-Val34Leu, PAI-1(4G/5G), HPA-1, MTHFR-C677T, MTHFR-A1298C, ACE(I/D) and APOE( ε2-4) was performed using CVD St...
Source: Pediatric Neurology - June 27, 2023 Category: Neurology Authors: Jasna Lenicek Krleza, Desiree Coen Herak, Ivana Đakovic, Katarina Vulin, Goran Roic, Ana Tripalo Batoš, Andrea Čeri, Renata Zadro, Vlasta Đuranovic Tags: Research Paper Source Type: research

Stroke by Carotid Artery Complete Occlusion in Kawasaki Disease: Case Report and Review of Literature
Conclusion: Stroke is a rare neurological complication in Kawasaki disease. Optimal treatment should be begun as soon as possible after diagnosis. Intravenous immunoglobulins seem to reduce the cerebrovascular complications, but evaluation of hydration status is strongly recommended before performing such treatment.
Source: Pediatric Neurology - October 7, 2013 Category: Neurology Authors: Isabelle Sabatier, Stéphane Chabrier, Amandine Brun, Laure Hees, Anne Cheylus, Randy Gollub, Nouchine Hadjikhani, Jian Kong, Vincent des Portes, Daniel Floret, Aurore Curie Tags: Clinical Observations Source Type: research

An atypical case of Canavan disease with stroke-like presentation
Canavan disease is an autosomal recessive leukodystrophy caused by a deficiency of aspartoacylase. The disease has a severe course, with death occurring in the first few years of life. Atypical patients with mild courses have been reported, but acute presentations similar to stroke have not been well-described.
Source: Pediatric Neurology - October 25, 2014 Category: Neurology Authors: Katherine E. Delaney, Stephen F. Kralik, Bryan E. Hainline, Meredith R. Golomb Tags: Clinical Observations Source Type: research

Spinal cord stroke presenting with acute monoplegia in a seventeen-year-old tennis player
Acute monoplegia is a rare presentation for spinal cord stroke, which usually presents with paraplegia or paraparesis.
Source: Pediatric Neurology - November 26, 2015 Category: Neurology Authors: Julie Nelson, Chang Y. Ho, Meredith R. Golomb Tags: Clinical Observations Source Type: research

Preparing for a “Pediatric Stroke Alert”
Childhood arterial ischemic stroke (AIS) is an important cause of morbidity and mortality in children. Hyperacute treatment strategies remain controversial and challenging, especially in the setting of increasingly proven medical and endovascular options in adults. Although national and international pediatric guidelines have given initial direction about acute therapy and management,1;2 pediatric centers have traditionally lacked the infrastructure to triage, diagnose and treat childhood AIS quickly.
Source: Pediatric Neurology - December 11, 2015 Category: Neurology Authors: Timothy J. Bernard, Neil R. Friedman, Nicholas V. Stence, William Jones, Rebecca Ichord, Catherine Amlie-Lefond, Michael M. Dowling, Michael J. Rivkin Tags: Topical Review Source Type: research

Spinal Cord Stroke Presenting With Acute Monoplegia in a 17-Year-Old Tennis Player
Acute monoplegia is a rare presentation for spinal cord stroke, which usually presents with paraplegia or paraparesis.
Source: Pediatric Neurology - November 26, 2015 Category: Neurology Authors: Julie A. Nelson, Chang Y. Ho, Meredith R. Golomb Tags: Clinical Observations Source Type: research