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Source: Journal of Neurosurgery

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Total 581 results found since Jan 2013.

Upregulation of miR-216a exerts neuroprotective effects against ischemic injury through negatively regulating JAK2/STAT3-involved apoptosis and inflammatory pathways.
CONCLUSIONS These findings suggest that upregulation of miR-216a, which targets JAK2, could induce neuroprotection against ischemic injury in vitro and in vivo, which provides a potential therapeutic target for ischemic stroke. PMID: 29521586 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - March 9, 2018 Category: Neurosurgery Authors: Tian YS, Zhong D, Liu QQ, Zhao XL, Sun HX, Jin J, Wang HN, Li GZ Tags: J Neurosurg Source Type: research

MicroRNA-195 protection against focal cerebral ischemia by targeting CX3CR1.
CONCLUSIONSTaken together, these findings suggest that miR-195 promotes neuronal cell survival against chronic cerebral ischemic damage by inhibiting CX3CR1-mediated neuroinflammation. This indicates that miR-195 may represent a novel target that regulates neuroinflammation and brain injury, thus offering a new treatment strategy for cerebral ischemic disorders. PMID: 30497184 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - November 1, 2018 Category: Neurosurgery Tags: J Neurosurg Source Type: research

Genetic variation in soluble epoxide hydrolase: association with outcome after aneurysmal subarachnoid hemorrhage.
Conclusions Genetic polymorphisms of sEH are associated with neurological and vital outcomes after aneurysmal SAH. PMID: 25216066 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - September 12, 2014 Category: Neurosurgery Authors: Martini RP, Ward J, Siler DA, Eastman JM, Nelson JW, Borkar RN, Alkayed NJ, Dogan A, Cetas JS Tags: J Neurosurg Source Type: research

Clinical utility of a screening protocol for blunt cerebrovascular injury using computed tomography angiography.
CONCLUSIONS The results of this study suggest that a CTA screening protocol for BCVI may be of clinical benefit with possible reduction in ischemic complications. The treatment of BCVI with antiplatelet agents appears to be safe. PMID: 27104846 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - April 21, 2016 Category: Neurosurgery Authors: Tso MK, Lee MM, Ball CG, Morrish WF, Mitha AP, Kirkpatrick AW, Wong JH Tags: J Neurosurg Source Type: research

Long-term and delayed functional recovery in patients with severe cerebrovascular and traumatic brain injury requiring tracheostomy.
CONCLUSIONS Among patients with severe brain injury requiring tracheostomy and tube feeding at ICU discharge, 46% regained the ability to walk and 37% performed B-ADLs 2-3 years after injury. DFR beyond 1-3 and 6-12 months was seen in over 30% of survivors, with no significant difference between sTBI and severe stroke. PMID: 29979120 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - July 6, 2018 Category: Neurosurgery Authors: Wabl R, Williamson CA, Pandey AS, Rajajee V Tags: J Neurosurg Source Type: research

Revascularization surgery for symptomatic non-moyamoya intracranial arterial stenosis or occlusion.
CONCLUSIONSProphylactic arterial pedicle bypass surgery for anterior circulation ischemia is associated with high graft patency and low stroke and surgical complication rates. Higher risks are associated with acute procedures, typically for posterior circulation pathology and requiring VIGs. A carefully selected subgroup of individuals with hemodynamic insufficiency and ischemic symptoms is likely to benefit from cerebral revascularization surgery. PMID: 30738386 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - February 8, 2019 Category: Neurosurgery Authors: Gunawardena M, Rogers JM, Stoodley MA, Morgan MK Tags: J Neurosurg Source Type: research

dl-3-n-butylphthalide for alleviation of neurological deficit after combined extracranial-intracranial revascularization for moyamoya disease: a propensity score-matched analysis.
CONCLUSIONSPostoperative administration of NBP may alleviate perioperative neurological deficits after revascularization surgery for MMD, especially in patients with ischemic MMD and unfavorable preoperative status. The results of this study suggest that randomized controlled trials to assess the potential benefit of NBP in patients with MMD may be warranted. PMID: 30771781 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - February 15, 2019 Category: Neurosurgery Authors: Li Z, Lu J, Ma L, Wu C, Xu Z, Chen X, Ye X, Wang R, Zhao Y Tags: J Neurosurg Source Type: research

Revascularization and functional outcomes after mechanical thrombectomy: an update to key metrics.
CONCLUSIONS: As MT has established acute ischemic stroke as a neurosurgical disease, there is a pressing need to understand the hospital course, hospital- and procedure-related complications, and outcomes for this new patient population. The authors provide a detailed account of key metrics for MT with the latest device technology and identify the predictors of unfavorable outcomes and inpatient mortality. PMID: 31518981 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - September 12, 2019 Category: Neurosurgery Authors: Mouchtouris N, Al Saiegh F, Fitchett E, Andrews CE, Lang MJ, Ghosh R, Schmidt RF, Chalouhi N, Barros G, Zarzour H, Romo V, Herial N, Jabbour P, Tjoumakaris SI, Rosenwasser RH, Gooch MR Tags: J Neurosurg Source Type: research

Moyamoya disease versus moyamoya syndrome: comparison of presentation and outcome in 338 hemispheres.
CONCLUSIONS: MMD and MMS have largely comparable clinical and angiographic phenotypes with analogously favorable responses to surgical revascularization. PMID: 31585423 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - October 3, 2019 Category: Neurosurgery Authors: Feghali J, Xu R, Yang W, Liew JA, Blakeley J, Ahn ES, Tamargo RJ, Huang J Tags: J Neurosurg Source Type: research

Late (5-20 years) outcomes after STA-MCA anastomosis and encephalo-duro-myo-arterio-pericranial synangiosis in patients with moyamoya disease.
CONCLUSIONS: The study results indicate that STA-MCA anastomosis and EDMAPS would be the best choice to prevent further ischemic and hemorrhagic stroke for longer than 10 years on the basis of the demonstrated widespread improvement in cerebral hemodynamics in both the MCA and ACA territories in the study patients. However, after 10 years postsurgery regular follow-up is essential to detect disease progression in the territory of the contralateral carotid artery and PCA and prevent late cerebrovascular events. PMID: 32168480 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - March 12, 2020 Category: Neurosurgery Authors: Kuroda S, Nakayama N, Yamamoto S, Kashiwazaki D, Uchino H, Saito H, Hori E, Akioka N, Kuwayama N, Houkin K Tags: J Neurosurg Source Type: research

Direct versus indirect bypass procedure for the treatment of ischemic moyamoya disease: results of an individualized selection strategy.
CONCLUSIONS: The selective use of an indirect bypass procedure for iMMD did not decrease the perioperative stroke rate. Direct bypass provided a significantly higher degree of revascularization. The authors conclude that direct bypass is the treatment of choice for iMMD. PMID: 32534489 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - June 11, 2020 Category: Neurosurgery Authors: Nielsen TH, Abhinav K, Sussman ES, Han SS, Weng Y, Bell-Stephens T, CNRN, Heit JJ, Steinberg GK Tags: J Neurosurg Source Type: research

Endarterectomy for symptomatic internal carotid artery web.
CONCLUSIONS: CEA is a safe and feasible treatment for symptomatic carotid webs and should be considered a viable alternative to CAS in this patient population. PMID: 32858515 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - August 27, 2020 Category: Neurosurgery Authors: Haynes J, Raz E, Tanweer O, Shapiro M, Esparza R, Zagzag D, Riina HA, Henderson C, Lillemoe K, Zhang C, Rostanski S, Yaghi S, Ishida K, Torres J, Mac Grory B, Nossek E Tags: J Neurosurg Source Type: research

Predicting neuroimaging eligibility for extended-window endovascular thrombectomy
CONCLUSIONS: Despite the limited sample size, compared with perfusion-based examinations, the clinical variables identified in this study accurately predicted which stroke patients would have salvageable penumbra (C statistic 71%-86%) in a range of clinical scenarios and treatment cutoffs. This prediction improved (C statistic 85%-86%) when utilized in patients with confirmed LVO or a less stringent tissue mismatch (TM < 1.2) cutoff. Larger patient registries should be used to validate and improve the predictive ability of these models.PMID:33636705 | DOI:10.3171/2020.8.JNS20386
Source: Journal of Neurosurgery - February 26, 2021 Category: Neurosurgery Authors: Adam de Havenon Kole Mickolio Steven O'Donnell Greg Stoddard J Scott McNally Matthew Alexander Philipp Taussky Al-Wala Awad Source Type: research