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Source: Stroke
Therapy: Stem Cell Therapy
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Total 28 results found since Jan 2013.
Stem Cell-Based Immunomodulation After Stroke Topical Review
Source: Stroke - May 25, 2018 Category: Neurology Authors: Marieke C.S. Boshuizen, Gary K. Steinberg Tags: Inflammation, Stem Cells, Ischemic Stroke Topical Reviews Source Type: research
Are Stem Cells the Next Generation of Stroke Therapeutics? Focused Updates in Cerebrovascular Disease
Source: Stroke - April 23, 2018 Category: Neurology Authors: Sean I. Savitz Tags: Stem Cells Focused Updates in Cerebrovascular Disease Source Type: research
Customized Brain Cells for Stroke Patients Using Pluripotent Stem Cells Focused Updates in Cerebrovascular Disease
Source: Stroke - April 23, 2018 Category: Neurology Authors: Zaal Kokaia, Irene L. Llorente, S. Thomas Carmichael Tags: Basic Science Research, Cell Therapy, Ischemia, Stem Cells Focused Updates in Cerebrovascular Disease Source Type: research
Future of Animal Modeling for Poststroke Tissue Repair Focused Updates in Cerebrovascular Disease
Source: Stroke - April 23, 2018 Category: Neurology Authors: Michel M. Modo, Jukka Jolkkonen, Marietta Zille, Johannes Boltze Tags: Animal Models of Human Disease, Basic Science Research, Cell Therapy, Stem Cells, Translational Studies Focused Updates in Cerebrovascular Disease Source Type: research
Human Neural Stem Cell Extracellular Vesicles Improve Recovery in a Porcine Model of Ischemic Stroke Basic Sciences
Conclusions—This study demonstrated for the first time that in a large animal model novel NSC EVs significantly improved neural tissue preservation and functional levels post-MCAO, suggesting NSC EVs may be a paradigm changing stroke therapeutic.
Source: Stroke - April 23, 2018 Category: Neurology Authors: Robin L. Webb, Erin E. Kaiser, Brian J. Jurgielewicz, Samantha Spellicy, Shelley L. Scoville, Tyler A. Thompson, Raymond L. Swetenburg, David C. Hess, Franklin D. West, Steven L. Stice Tags: Animal Models of Human Disease, Basic Science Research, Translational Studies, Treatment, Ischemic Stroke Original Contributions Source Type: research
Accelerating Cell Therapy for Stroke in Japan Special Reports
Source: Stroke - March 26, 2018 Category: Neurology Authors: Kiyohiro Houkin, Hideo Shichinohe, Koji Abe, Teruyo Arato, Mari Dezawa, Osamu Honmou, Nobutaka Horie, Yasuo Katayama, Kohsuke Kudo, Satoshi Kuroda, Tomohiro Matsuyama, Ichiro Miyai, Izumi Nagata, Kuniyasu Niizuma, Ken Sakushima, Masanori Sasaki, Norihiro Tags: Cell Therapy, Clinical Studies, Stem Cells, Translational Studies, Ischemic Stroke Special Report Source Type: research
Acute or Delayed Systemic Administration of Human Amnion Epithelial Cells Improves Outcomes in Experimental Stroke Basic Sciences
Conclusions—Systemic poststroke administration of hAECs elicits marked neuroprotection and facilitates mechanisms of repair and recovery.
Source: Stroke - February 26, 2018 Category: Neurology Authors: Megan A. Evans, Rebecca Lim, Hyun Ah Kim, Hannah X. Chu, Chantelle V. Gardiner-Mann, Kimberly W.E. Taylor, Christopher T. Chan, Vanessa H. Brait, Seyoung Lee, Quynh Nhu Dinh, Antony Vinh, Thanh G. Phan, Velandai K. Srikanth, Henry Ma, Thiruma V. Arumugam, Tags: Animal Models of Human Disease, Cell Therapy, Stem Cells, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research
Integrin {alpha}4 Overexpression on Rat Mesenchymal Stem Cells Enhances Transmigration and Reduces Cerebral Embolism After Intracarotid Inȷection Brief Report
Conclusions—ITGA4 overexpression on MSCs enhances transendothelial migration in vitro, but not in vivo, although it improves safety after intracarotid transplantation into stroke rats.
Source: Stroke - September 25, 2017 Category: Neurology Authors: Li–li Cui, Franziska Nitzsche, Evgeny Pryazhnikov, Marina Tibeykina, Laura Tolppanen, Jussi Rytkonen, Tuulia Huhtala, Jing–wei Mu, Leonard Khiroug, Johannes Boltze, Jukka Jolkkonen Tags: Cell Therapy, Translational Studies, Ischemic Stroke Brief Reports Source Type: research
Poststroke Sonic Hedgehog Agonist Treatment Improves Functional Recovery by Enhancing Neurogenesis and Angiogenesis Basic Sciences
Conclusions—These data confirm an important role for the hedgehog pathway in poststroke brain repair and functional recovery, suggesting a prolonged treatment window for potential treatment strategy to modulate sonic hedgehog pathway after stroke.
Source: Stroke - May 22, 2017 Category: Neurology Authors: Yongming Jin, Austin Barnett, Yifan Zhang, Xin Yu, Yu Luo Tags: Cerebrovascular Disease/Stroke, Cognitive Impairment, Ischemic Stroke, Neurogenesis Original Contributions Source Type: research
MicroRNA cluster miR-17-92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats Basic Sciences
Conclusions—Our data suggest that treatment of stroke with tailored exosomes enriched with the miR-17–92 cluster increases neural plasticity and functional recovery after stroke, possibly via targeting phosphatase and tensin homolog to activate the PI3K/protein kinase B/mechanistic target of rapamycin/glycogen synthase kinase 3β signaling pathway.
Source: Stroke - February 26, 2017 Category: Neurology Authors: Hongqi Xin, Mark Katakowski, Fengjie Wang, Jian-Yong Qian, Xian Shuang Liu, Meser M. Ali, Benjamin Buller, Zheng Gang Zhang, Michael Chopp Tags: Animal Models of Human Disease, Cell Signaling/Signal Transduction, Cell Therapy, Stem Cells, Translational Studies Original Contributions Source Type: research
Human Muse Cells Reconstruct Neuronal Circuitry in Subacute Lacunar Stroke Model Basic Sciences
Conclusions—Transplantation at the delayed subacute phase showed muse cells differentiated into neural cells, facilitated neural reconstruction, improved functions, and displayed solid safety outcomes over prolonged graft maturation period, indicating their therapeutic potential for lacunar stroke.
Source: Stroke - January 22, 2017 Category: Neurology Authors: Hiroki Uchida, Kuniyasu Niizuma, Yoshihiro Kushida, Shohei Wakao, Teiji Tominaga, Cesario V. Borlongan, Mari Dezawa Tags: Cell Therapy, Stem Cells, Translational Studies, Ischemic Stroke Original Contributions Source Type: research
Cannabinoid Type-2 Receptor Drives Neurogenesis and Improves Functional Outcome After Stroke Basic Sciences
Conclusions—Our data support that CB2R is fundamental for driving neuroblast migration and suggest that an endocannabinoid tone is required for poststroke neurogenesis by promoting neuroblast migration toward the injured brain tissue, increasing the number of new cortical neurons and, conceivably, enhancing motor functional recovery after stroke.
Source: Stroke - December 22, 2016 Category: Neurology Authors: Isabel Bravo–Ferrer, Maria I. Cuartero, Juan G. Zarruk, Jesus M. Pradillo, Olivia Hurtado, Victor G. Romera, Javier Diaz–Alonso, Juan M. Garcia–Segura, Manuel Guzman, Ignacio Lizasoain, Ismael Galve–Roperh, Maria A. Moro Tags: Stem Cells, Pharmacology, Neurogenesis Original Contributions Source Type: research
Letter by Clark Regarding Article, “Clinical Outcomes of Transplanted Modified Bone Marrow-Derived Mesenchymal Stem Cells in Stroke: A Phase 1/2a Study” Letter to the Editor
Source: Stroke - November 27, 2016 Category: Neurology Authors: Ian A. Clark Tags: Ischemic Stroke Letters to the Editor Source Type: research
Response by Steinberg et al to Letter Regarding Article, “Clinical Outcomes of Transplanted Modified Bone Marrow-Derived Mesenchymal Stem Cells in Stroke: A Phase 1/2A Study” Letter to the Editor
Source: Stroke - November 27, 2016 Category: Neurology Authors: Gary K. Steinberg, Douglas Kondziolka, Damien Bates, on behalf of the SB623 Stroke Phase 1/2A Study Group Tags: Stem Cells Letters to the Editor Source Type: research
Neurorestorative Responses to Delayed Human Mesenchymal Stromal Cells Treatment of Stroke in Type 2 Diabetic Rats Basic Sciences
Conclusions—In T2DM stroke rats, delayed hMSC treatment significantly improves neurological functional outcome and increases neurorestorative effects and M2 macrophage polarization. Increasing brain platelet-derived growth factor expression may contribute to hMSC-induced neurorestoration.
Source: Stroke - October 23, 2016 Category: Neurology Authors: Yan, T., Venkat, P., Chopp, M., Zacharek, A., Ning, R., Roberts, C., Zhang, Y., Lu, M., Chen, J. Tags: Cell Therapy, Stem Cells, Diabetes, Type 2, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research
