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Routine Clinical Evaluation of Cerebrovascular Reserve Capacity Using Carbogen in Patients With Intracranial Stenosis Clinical Sciences
Conclusions— Carbogen-induced CVR elicited no added adverse events and provided a surrogate marker of cerebrovascular reserve consistent with intracranial vasculopathy.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Donahue, M. J., Dethrage, L. M., Faraco, C. C., Jordan, L. C., Clemmons, P., Singer, R., Mocco, J., Shyr, Y., Desai, A., O'Duffy, A., Riebau, D., Hermann, L., Connors, J., Kirshner, H., Strother, M. K. Tags: Brain Circulation and Metabolism, Other imaging, Risk Factors for Stroke Clinical Sciences Source Type: research

Community-Based Stroke System of Care for Chinese Rural Areas Clinical Sciences
Conclusions— A stroke system of care would be reliable and practical in Chinese rural areas. Clinical Trial Registration— URL: http://www.chictr.org. Unique identifier: ChiCTR-RCH-13003408.
Source: Stroke - July 28, 2014 Category: Neurology Authors: He, M., Wang, J., Gong, L., Dong, Q., Ji, N., Xing, H., Zhou, Y., Qin, S., Wang, H., Zhang, H., Hui, R., Wang, Y. Tags: Other Stroke Treatment - Medical Clinical Sciences Source Type: research

Desmopressin Improves Platelet Activity in Acute Intracerebral Hemorrhage Brief Reports
Conclusions— Intravenous desmopressin was well tolerated and improved platelet activity after acute intracerebral hemorrhage. Larger studies are needed to determine its potential effects on reducing hematoma growth versus platelet transfusion or placebo. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00961532.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Naidech, A. M., Maas, M. B., Levasseur-Franklin, K. E., Liotta, E. M., Guth, J. C., Berman, M., Rosenow, J. M., Lindholm, P. F., Bendok, B. R., Prabhakaran, S., Bernstein, R. A., Kwaan, H. C. Tags: Intracerebral Hemorrhage, Other Stroke Treatment - Medical, Platelets Brief Reports Source Type: research

Six-Minute Magnetic Resonance Imaging Protocol for Evaluation of Acute Ischemic Stroke: Pushing the Boundaries Clinical Sciences
Conclusions— A 6-minute multimodal MR protocol with good diagnostic quality is feasible for the evaluation of patients with acute ischemic stroke and can result in significant reduction in scan time rivaling that of the multimodal computed tomographic protocol.
Source: Stroke - June 23, 2014 Category: Neurology Authors: Nael, K., Khan, R., Choudhary, G., Meshksar, A., Villablanca, P., Tay, J., Drake, K., Coull, B. M., Kidwell, C. S. Tags: CT and MRI, Acute Cerebral Infarction, Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Pretreatment Blood-Brain Barrier Damage and Post-Treatment Intracranial Hemorrhage in Patients Receiving Intravenous Tissue-Type Plasminogen Activator Clinical Sciences
Conclusions— A perfusion-weighted imaging–derived index of blood–brain barrier damage measured before intravenous tissue-type plasminogen activator is given is associated with the severity of ICH after treatment in patients with acute ischemic stroke.
Source: Stroke - June 23, 2014 Category: Neurology Authors: Leigh, R., Jen, S. S., Hillis, A. E., Krakauer, J. W., Barker, P. B., on behalf of the STIR and VISTA Imaging Investigators, Albers, Davis, Donnan, Fisher, Furlan, Grotta, Hacke, Kang, Kidwell, Koroshetz, Lees, Lev, Liebeskind, Sorensen, Thijs, Thomalla, Tags: CT and MRI, Acute Cerebral Infarction, Intracerebral Hemorrhage, Thrombolysis, Other Vascular biology Clinical Sciences Source Type: research

Varying Correlation Between 18F-Fluorodeoxyglucose Positron Emission Tomography and Dynamic Contrast-Enhanced MRI in Carotid Atherosclerosis: Implications for Plaque Inflammation Brief Reports
Conclusions— The correlation between 18F-fluorodeoxyglucose positron emission tomography and dynamic contrast-enhanced MRI measurements varied with clinical conditions, pointing to a complex interplay between macrophages and neovessels under different pathophysiological conditions. The moderate correlation shown only in symptomatic plaques indicates the presence of acute plaque inflammation with increased metabolic activity and cytokine production by inflammatory cells.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Wang, J., Liu, H., Sun, J., Xue, H., Xie, L., Yu, S., Liang, C., Han, X., Guan, Z., Wei, L., Yuan, C., Zhao, X., Chen, H. Tags: Pathophysiology, Imaging, Carotid Stenosis, Mechanism of atherosclerosis/growth factors Brief Reports Source Type: research

Cerebral Perfusion and Blood Pressure Do Not Affect Perihematoma Edema Growth in Acute Intracerebral Hemorrhage Clinical Sciences
Conclusions— Lower perihematoma CBF and BP treatment do not exacerbate edema growth. These data do not support a cytotoxic edema pathogenesis. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00963976.
Source: Stroke - April 28, 2014 Category: Neurology Authors: McCourt, R., Gould, B., Gioia, L., Kate, M., Coutts, S. B., Dowlatshahi, D., Asdaghi, N., Jeerakathil, T., Hill, M. D., Demchuk, A. M., Buck, B., Emery, D., Butcher, K., on behalf of the ICH ADAPT Investigators Tags: Cerebrovascular disease/stroke, Acute Cerebral Hemorrhage, Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Assessing the Clinical Effect of Residual Cortical Disconnection After Ischemic Strokes Clinical Sciences
Conclusions— We suggest that cortical disconnection, as measured by the structural connectome, is an independent predictor of naming impairment in patients with chronic aphasia. The full extent of clinically relevant brain damage after an ischemic stroke may be underappreciated by visual inspection of cortical necrosis alone.
Source: Stroke - March 24, 2014 Category: Neurology Authors: Bonilha, L., Rorden, C., Fridriksson, J. Tags: Exercise/exercise testing/rehabilitation, Other imaging Clinical Sciences Source Type: research

Time Course of Early Postadmission Hematoma Expansion in Spontaneous Intracerebral Hemorrhage Clinical Sciences
Conclusions— EHE was reliably reflected by transcranial B-mode ultrasound and mainly occurred within the first 7 to 8 hours after symptom onset. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01472224.
Source: Stroke - March 24, 2014 Category: Neurology Authors: Ovesen, C., Christensen, A. F., Krieger, D. W., Rosenbaum, S., Havsteen, I., Christensen, H. Tags: Acute Cerebral Hemorrhage, Doppler ultrasound, Transcranial Doppler etc., Intracerebral Hemorrhage Clinical Sciences Source Type: research

Clinical Associations and Causes of Convexity Subarachnoid Hemorrhage Brief Reports
Conclusions— cSAH comprises a significant proportion of SAH. Commonest causes are cerebral amyloid angiopathy in the elderly and reversible cerebral vasoconstriction syndrome in the young, but differential diagnosis is broad. Misdiagnosis is common and leads to potentially harmful treatments.
Source: Stroke - March 24, 2014 Category: Neurology Authors: Khurram, A., Kleinig, T., Leyden, J. Tags: Acute Cerebral Hemorrhage, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage Brief Reports Source Type: research

Anatomic Pattern of Intracerebral Hemorrhage Expansion: Relation to CT Angiography Spot Sign and Hematoma Center Brief Reports
Conclusions— Hemorrhages expand nonuniformly around their surface with a tendency for greater expansion closer to their center. These findings provide a novel framework for analyzing mechanisms underlying hemorrhage growth and response to treatment.
Source: Stroke - March 24, 2014 Category: Neurology Authors: Boulouis, G., Dumas, A., Betensky, R. A., Brouwers, H. B., Fotiadis, P., Vashkevich, A., Ayres, A., Schwab, K., Romero, J. M., Smith, E. E., Viswanathan, A., Goldstein, J. N., Rosand, J., Gurol, M. E., Greenberg, S. M. Tags: Acute Cerebral Hemorrhage, Intracerebral Hemorrhage Brief Reports Source Type: research

Are Arterial Calcifications a Marker of Remodeling in Vertebrobasilar Territory? Brief Reports
Conclusions— Higher prevalence of calcifications in vertebrobasilar artery territory of patients with stroke is associated with advanced age, larger arterial area, and history of previous transient ischemic attack/stroke.
Source: Stroke - February 24, 2014 Category: Neurology Authors: Pikija, S., Magdic, J., Knific, A. Tags: Acute Cerebral Infarction Brief Reports Source Type: research

Gradual Lesion Expansion and Brain Shrinkage Years After Stroke Brief Reports
Conclusions— We show gradual lesion expansion many years after stroke, beyond that expected by normal aging and after controlling for other variables. Future studies need to understand how structural reorganization enables long-term recovery even when the brain is shrinking.
Source: Stroke - February 24, 2014 Category: Neurology Authors: Seghier, M. L., Ramsden, S., Lim, L., Leff, A. P., Price, C. J. Tags: Behavioral Changes and Stroke, Computerized tomography and Magnetic Resonance Imaging Brief Reports Source Type: research

Predicting Future Brain Tissue Loss From White Matter Connectivity Disruption in Ischemic Stroke Clinical Sciences
Conclusions— ChaCo scores varied, but the most affected regions included those with sensorimotor, perception, learning, and memory functions. Correlations between baseline ChaCo and subsequent tissue loss suggest that the Network Modification Tool could be used to identify regions most susceptible to remote degeneration from acute infarcts.
Source: Stroke - February 24, 2014 Category: Neurology Authors: Kuceyeski, A., Kamel, H., Navi, B. B., Raj, A., Iadecola, C. Tags: Computerized tomography and Magnetic Resonance Imaging, Pathology of Stroke Clinical Sciences Source Type: research

Fluorescent Molecular Peroxidation Products: A Prognostic Biomarker of Early Neurologic Deterioration After Thrombolysis Clinical Sciences
Conclusions— FMPPs might be a valuable biomarker of poor early neurological outcome and be related to the appearance of symptomatic intracranial hemorrhage in tissue plasminogen activator–treated patients, one of the most feared neurological complications after thrombolytic treatment of acute ischemic stroke.
Source: Stroke - January 27, 2014 Category: Neurology Authors: Llombart, V., Dominguez, C., Bustamante, A., Rodriguez-Sureda, V., Martin-Gallan, P., Vilches, A., Garcia-Berrocoso, T., Penalba, A., Hernandez-Guillamon, M., Rubiera, M., Ribo, M., Eschenfelder, C., Giralt, D., Molina, C. A., Alvarez-Sabin, J., Rosell, A Tags: Cerebrovascular disease/stroke, Acute Cerebral Infarction, Intracerebral Hemorrhage, Thrombolysis, Oxidant stress Clinical Sciences Source Type: research

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