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Source: Brain Research
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Total 28 results found since Jan 2013.
Montelukast Sodium Protects against Focal Cerebral Ischemic Injury by Regulating Inflammatory Reaction via Promoting Microglia Polarization
CONCLUSION: Montelukast sodium can protect against focal cerebral ischemic injury by regulating inflammatory reaction via promoting microglia polarization.PMID:37499731 | DOI:10.1016/j.brainres.2023.148498
Source: Brain Research - July 27, 2023 Category: Neurology Authors: Yanling Wang Ho Jun Yun Yuchuan Ding Huishan Du Xiaokun Geng Source Type: research
Else_BRB_110660Docosahexaenoic acid promotes M2 microglia phenotype via activating PPAR γ-mediated ERK/AKT pathway against cerebral ischemia-reperfusion injury
Brain Res Bull. 2023 May 4:110660. doi: 10.1016/j.brainresbull.2023.110660. Online ahead of print.ABSTRACTIn ischemia-reperfusion stroke, microglia play a dual role in brain injury as well as brain repair, and promoting their switch from a pro-inflammatory M1 phenotype to an anti-inflammatory M2 phenotype is considered to be a potential therapeutic strategy. Docosahexaenoic acid (DHA) is an essential long-chain omega-3 polyunsaturated fatty acid that exhibits potent anti-inflammatory properties in the acute phase of ischemic stroke, but its effect on microglia polarization is unknown. Thus, the objective of this study was ...
Source: Brain Research - May 6, 2023 Category: Neurology Authors: Huijing Lv Shuai Jia Yanan Sun Meng Pang E Lv Xiangling Li Qinghui Meng Yanqiang Wang Source Type: research
Evaluation of the effect of mesenchymal stem cells injection in the nucleus accumbens on the morphine reinstatement behavior in a conditioned place preference model in Wistar rat: expression changes of NMDA receptor subunits and NT-3
This study was designed to discover the effect of MSCs injection in the nucleus accumbens (NAc) on the reinstatement of behavior in morphine-induced conditioned place preference (CPP) in male rats. The CPP was induced via intra-peritoneal (i.p.) morphine injection (5mg/kg) for three consecutive days. After being tested for CPP induction, animals received MSCs or culture medium (DMEM F-12) in their NAc using stereotaxic surgery. Following extinction, a priming dose of morphine (2mg/kg) was administered to induce reinstatement. Expression of GluN1, GluN2A, and GluN2B subunits of the NMDA receptor and the NT-3 gene in the NAc...
Source: Brain Research - February 28, 2023 Category: Neurology Authors: Parviz Dousti Kataj Nasim Vousooghi Mahmoud Reza Hadjighassem Maryam Farahmandfar Somayeh Ebrahimi-Barough Source Type: research
Metformin enhances neural precursor cells migration and functional recovery after ischemic stroke in mice
Exp Brain Res. 2023 Jan 8. doi: 10.1007/s00221-023-06547-3. Online ahead of print.ABSTRACTResident neural precursor cells (NPCs) activation is a promising therapeutic strategy for brain repair. This strategy involves stimulating multiple stages of NPCs development, including proliferation, self-renewal, migration, and differentiation. Metformin, an FDA-approved diabetes drug, has been shown to promote the proliferation and differentiation of NPCs. However, it is still unclear whether metformin promotes the migration of NPCs. EVOS living cell imaging system was used for observing the migration for primary NPCs dynamically i...
Source: Brain Research - January 7, 2023 Category: Neurology Authors: Liang Zhang Jing Zhang Xiaoming Zhu Wei Jiao Yang Yang Youping Wu Likun Yang Yuhai Wang Source Type: research
Exosome therapies improve outcome in rodents with ischemic stroke; Meta-analysis
This study systematically evaluated the efficacy of exosome therapy in ischemic stroke based on preclinical studies in rodent models.METHODS: We reviewed existing literature on exosome therapy in rodent stroke models from various databases, and reviewed the interventional measures, and outcome measures systematically, with changes in the infarct volume and functional scores as outcome parameters. Seventeen homogeneous studies were found qualitatively acceptable for meta-analysis. The study used software RevMan 5.3 to conduct the meta-analysis (PROSPERO Register Number: CRD42022314138) RESULTS: Compared to placebo, exosomes...
Source: Brain Research - January 2, 2023 Category: Neurology Authors: Simy Grace Cherian Sunil K Narayan Murugesan Arumugam Source Type: research
Inhibition of BRD4 decreases fibrous scarring after ischemic stroke in rats by inhibiting the phosphorylation of Smad2/3
CONCLUSIONS: This study is the first to indicate that inhibition of BRD4 delays fibrous scarring after ischemic stroke through mechanisms involving the phosphorylation of Smad2/3.PMID:36244457 | DOI:10.1016/j.brainres.2022.148126
Source: Brain Research - October 16, 2022 Category: Neurology Authors: Xuemei Li Huimin Zhu Jun Wen Jiagui Huang Yue Chen Mingfen Tian Jiangxia Ren Li Zhou Qin Yang Source Type: research
Cranial electrotherapy stimulation alleviates depression-like behavior of post-stroke depression rats by upregulating GPX4-mediated BDNF expression
Conclusion: CES improves depression-like behavior of PSD rats through upregulation of GPX4-mediated BDNF expression in the hippocampus.PMID:36116735 | DOI:10.1016/j.bbr.2022.114117
Source: Brain Research - September 18, 2022 Category: Neurology Authors: Xiaoju Wang Peng Xia Jiulong Song Ting Yang Changjun Yu Kai Cheng Anliang Chen Xueping Li Source Type: research
GrpEL1 Regulates Mitochondrial Unfolded Protein Response after Experimental Subarachnoid Hemorrhage in vivo and in vitro
In conclusion, the reduced GrpEL1-mtHSP70 complex is an essential factor affecting UPRmt in EBI after SAH. Increasing GrpEL1 promotes GrpEL1 and mtHSP70 binding, promoting the neuronal mitochondrial homeostasis, and might be an essential clinical intervention target for EBI after SAH.PMID:35093469 | DOI:10.1016/j.brainresbull.2022.01.014
Source: Brain Research - January 30, 2022 Category: Neurology Authors: Chao Ma Bixi Gao Zongqi Wang Wanchun You Zhengquan Yu Haitao Shen Xiang Li Haiying Li Xuwei Zhang Zhong Wang Gang Chen Source Type: research
Injectable biomaterial shuttles for cell therapy in stroke
Brain Res Bull. 2021 Aug 12:S0361-9230(21)00242-2. doi: 10.1016/j.brainresbull.2021.08.002. Online ahead of print.ABSTRACTIschemic stroke (IS) is the leading cause of disability and contributes to a significant socio-economic cost in the western world. Brain repair strategies investigated in the pre-clinical models include the delivery of drug or cell-based therapeutics; which is hindered by the complex anatomy and functional organization of the brain. Biomaterials can be instrumental in alleviating some of these challenges by providing a structural support, localization, immunomodulation and/or modulating cellular cross-t...
Source: Brain Research - August 15, 2021 Category: Neurology Authors: Juhi Samal Tatiana Segura Source Type: research
