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Comparison of Morphological Features and Flow Velocity of the Left Atrial Appendage among Patients with Atrial Fibrillation Alone, Transient Ischemic Attack and Cardioembolic Stroke
The left atrial appendage (LAA) is a major source of emboli responsible for cardioembolic stroke (CES). We hypothesized that there could be differences in the morphological and functional features of LAAs among patients with atrial fibrillation (AF) alone, patients with cardioembolic transient ischemic attack (CETIA) and patients with CES. Patients with AF and CETIA/CES were included in either a CETIA group or a CES group. Patients with AF without past histories of stroke were included in an AF/non-CVA group.
Source: The American Journal of Cardiology - February 27, 2017 Category: Cardiology Authors: Yonggu Lee, Hwan-Cheol Park, Youkyung Lee, Soon-Gil Kim Source Type: research

Relation of Low-Density Lipoprotein Cholesterol to Ischemic Stroke in Patients With Nonvalvular Atrial Fibrillation
Low-density lipoprotein cholesterol (LDL-C) has been demonstrated as an independent risk factor of ischemic stroke, but the association of LDL-C with ischemic stroke in patients with nonvalvular atrial fibrillation (AF) remains uncertain. Our objective was to explore whether LDL-C could refine stroke stratification in AF patients. A total of 424 nonvalvular AF patients with ischemic stroke and 391 ones without ischemic stroke were enrolled. No patient had received antithrombotic therapy. Multivariate logistic regression analysis showed that LDL-C was an independent predictor of ischemic stroke in AF patients, with the adju...
Source: The American Journal of Cardiology - January 24, 2017 Category: Cardiology Authors: Zhiyong Qi, Hua Chen, Zhichao Wen, Fei Yuan, Huanchun Ni, Wen Gao, Jun Shen, Jian Li, Yangyi Lin, Ying Shan, Bo Jin, Pingping Yan, Haiming Shi, Xinping Luo Source Type: research

Usefulness of the MrWALLETS Scoring System to Predict First Diagnosed Atrial Fibrillation in Ischemic Stroke Patients
In this study we searched for echocardiographic parameters associated with first diagnosed AF, to form a scoring system for the identification of AF patients. We examined 571 ischemic stroke patients (72.7 ±13.5 years, 50.6% women), subdivided into 4 groups: documented cause without AF, first diagnosed AF, known paroxysmal AF, and permanent AF. All patients underwent transthoracic echocardiography, brain CT scan, carotid/vertebral ultrasound, and continuous ECG monitoring.
Source: The American Journal of Cardiology - January 4, 2017 Category: Cardiology Authors: Antonio Muscari, Andrea Bonfiglioli, Luca Faccioli, Marco Ghinelli, Donatella Magalotti, Francesco Manzetto, Anna Pontarin, Giovanni M. Puddu, Luca Spinardi, Eleonora Tubertini, Marco Zoli Source Type: research

Usefulness of the MrWALLETS Scoring System to Predict First Diagnosed Atrial Fibrillation in Patients With Ischemic Stroke
In this study, we searched for echocardiographic parameters associated with first diagnosed AF, to form a scoring system for the identification of patients with AF. We examined 571 patients with ischemic stroke (72.7  ± 13.5 years, 50.6% women), subdivided into 4 groups: documented cause without AF, first diagnosed AF, known paroxysmal AF, and permanent AF. All patients underwent transthoracic echocardiography, brain computed tomography scan, carotid/vertebral ultrasound, and continuous electrocardiographic monitoring.
Source: The American Journal of Cardiology - January 4, 2017 Category: Cardiology Authors: Antonio Muscari, Andrea Bonfiglioli, Luca Faccioli, Marco Ghinelli, Donatella Magalotti, Francesco Manzetto, Anna Pontarin, Giovanni M. Puddu, Luca Spinardi, Eleonora Tubertini, Marco Zoli Tags: Arrhythmias and Conduction Disturbances Source Type: research

Triggering of Stroke or Atrial Fibrillation by Percutaneous Coronary Intervention
I have read the article entitled “Percutaneous Coronary Intervention as a Trigger for Stroke” by Varmdal et al. 1 with great interest, recently published in journal. Their estimates indicated a substantially increased risk of ischemic stroke during the first 2 days after percutaneous coronary intervention (PCI). Relative risk t hen decreased gradually but stayed elevated for 8 weeks. Increased awareness of this vulnerable period after PCI in clinicians and patients could contribute to earlier detection and treatment for patients suffering a postprocedural stroke 1.
Source: The American Journal of Cardiology - January 2, 2017 Category: Cardiology Authors: Levent Cerit Source Type: research

Gender-Specific Differences for Risk of Disability and Death in Atrial Fibrillation-Related Stroke
In this study, we examined patients with AF with ischemic stroke patient characteristics associated with increased stroke severity.
Source: The American Journal of Cardiology - October 6, 2016 Category: Cardiology Authors: Ryan C. Martin, W. Scott Burgin, Matthew B. Schabath, Bonnie Kirby, Sanders H. Chae, Michael G. Fradley, David Z. Rose, Arthur J. Labovitz Tags: Arrythmias and Conduction Disturbances Source Type: research

Percutaneous Coronary Intervention as a Trigger for Stroke
This study aimed to quantify the transient change in risk of stroke for up to 12 weeks after PCI. We applied the case-crossover method, using data from the Norwegian Patient Register on all hospitalizations in Norway in the period of 2008 through 2014. The relative risk (RR) of ischemic stroke was highest during the first two days after PCI (RR 17.5, 95% CI 4.2-72.8), and decreased gradually during the following weeks.
Source: The American Journal of Cardiology - September 28, 2016 Category: Cardiology Authors: Torunn Varmdal, Imre Janszky, Inger Johanne Bakken, Hanne Ellekj ær, Hild Fjærtoft, Siri Eldevik Håberg, Kaare Harald Bønaa Source Type: research

Usefulness of Atrial Fibrillation as a Marker for Adverse Cardiovascular Outcomes in Both Primary and Secondary Prevention in Patients with Implantable Cardioverter-Defibrillators
Whether the risk factors for cardiovascular (CV) outcomes are different in primary vs. secondary prevention implantable cardioverter-defibrillator (ICD) patients is unclear. We sought to identify predictors of CV outcomes in ICD recipients for primary (G1) vs. secondary prevention (G2). Consecutive patients who had ICD implanted during August 2005 –December 2009 were included. The primary outcome was a composite of appropriate shock, acute coronary syndrome, ischemic stroke, coronary revascularization, heart failure exacerbation, CV hospitalization, or all-cause death.
Source: The American Journal of Cardiology - August 22, 2016 Category: Cardiology Authors: Ian CY. Chang, Yusuf Agawami, Erin Austin, Wayne O. Adkisson, Henri Roukoz, Lisa N. von Wald, Scott Sakaguchi, David G. Benditt, Lin Y. Chen Source Type: research

Neurologic Complications of Unprotected Transcatheter Aortic Valve Implantation (From the Neuro-TAVI Trial)
This study sought to determine the frequency of neurologic injury, cerebral ischemic lesions, and cognitive dysfunction in subjects undergoing contemporary commercial transcatheter aortic valve implantation (TAVI) in the United States. Neuro-TAVR is the first prospective, multicenter study to employ serial systematic neurologic and cognitive assessments and DW-MRI (at 4 ±2 days postprocedure) to investigate the incidence and severity of neurologic injury following contemporary unprotected TAVI in the US.
Source: The American Journal of Cardiology - August 22, 2016 Category: Cardiology Authors: Alexandra J. Lansky, David Brown, Constantino Pena, Cody G. Pietras, Helen Parise, Vivian G. Ng, Stephanie Meller, Kevin J. Abrams, Michael Cleman, Pauliina Margolis, George Petrossian, Adam M. Brickman, Szilard Voros, Jeffrey Moses, John K. Forrest Source Type: research

Risk Factor Optimization and Guideline-Directed Medical Therapy in US Veterans With Peripheral Arterial and Ischemic Cerebrovascular Disease Compared to Veterans With Coronary Heart Disease
Cardiovascular disease (CVD) is a systemic process involving multiple vascular beds and includes coronary heart disease (CHD), ischemic cerebrovascular disease (ICVD), and peripheral arterial disease (PAD). All these manifestations are associated with an increased risk of subsequent myocardial infarction, stroke, and death. Guideline-directed medical therapy is recommended for all patients with CVD. In a cohort of US veterans, we identified 1,242,015 patients with CVD receiving care in 130 Veterans Affairs facilities from October 1, 2013 to September 30, 2014.
Source: The American Journal of Cardiology - July 28, 2016 Category: Cardiology Authors: Ravi S. Hira, Jennifer B. Cowart, Julia M. Akeroyd, David J. Ramsey, Yashashwi Pokharel, Vijay Nambi, Hani Jneid, Anita Deswal, Ali Denktas, Addison Taylor, Khurram Nasir, Christie M. Ballantyne, Laura A. Petersen, Salim S. Virani Tags: Coronary Artery Disease Source Type: research

Risk Factor Optimization And Guideline Directed Medical Therapy In US Veterans With Peripheral Arterial And Ischemic Cerebrovascular Disease Compared To Veterans With Coronary Heart Disease
Cardiovascular disease (CVD) is a systemic process involving multiple vascular beds and includes coronary heart disease (CHD), ischemic cerebrovascular disease (ICVD) and peripheral arterial disease (PAD). All these manifestations are associated with an increased risk of subsequent myocardial infarction, stroke and death. GDMT is recommended for all patients with CVD. In a cohort of US veterans, we identified 1,242,015 patients with CVD receiving care in 130 Veterans Affairs facilities between 10/1/2013 and 9/30/2014.
Source: The American Journal of Cardiology - July 28, 2016 Category: Cardiology Authors: Ravi S. Hira, Jennifer B. Cowart, Julia M. Akeroyd, David J. Ramsey, Yashashwi Pokharel, Vijay Nambi, Hani Jneid, Anita Deswal, Ali Denktas, Addison Taylor, Khurram Nasir, Christie M. Ballantyne, Laura A. Petersen, Salim S. Virani Source Type: research

Prognostic Implications of Left Ventricular Scar Determined by Late Gadolinium Enhanced Cardiac Magnetic Resonance in Patients with Atrial Fibrillation
Left ventricular (LV) scar identified by late gadolinium enhanced (LGE) cardiac magnetic resonance (CMR) is associated with adverse outcomes in coronary artery disease (CAD) and cardiomyopathies. We sought to determine the prognostic significance of LV-LGE in atrial fibrillation (AF). We studied 778 consecutive patients referred for radiofrequency ablation of AF who underwent CMR. Patients with CAD, prior myocardial infarction (MI), or hypertrophic or dilated cardiomyopathy were excluded. The endpoints of interest were major adverse cardiac and cerebrovascular events (MACCE), defined as a composite of cardiovascular death,...
Source: The American Journal of Cardiology - July 17, 2016 Category: Cardiology Authors: Promporn Suksaranjit, Christopher J. McGann, Nazem Akoum, Joseph Biskupiak, Gregory J. Stoddard, Eugene G. Kholmovski, Leenhapong Navaravong, Allen Rassa, Erik Bieging, Lowell Chang, Imran Haider, Nassir F. Marrouche, Brent D. Wilson Source Type: research

Relation of Periodontitis to Risk of Cardiovascular and All-Cause Mortality (From a Danish Nationwide Cohort Study)
Periodontitis and atherosclerosis are highly prevalent chronic inflammatory diseases and it has been suggested that periodontitis is an independent risk factor of cardiovascular disease (CVD) and that a causal link may exist between the two diseases. Using Danish national registers we identified a nationwide cohort of 17,691 patients who received a hospital diagnosis of periodontitis within a 15 year period and matched them with 83,003 controls from the general population. We performed Poisson regression analysis to determine crude and adjusted incidence rate ratios (IRRs) of myocardial infarction, ischemic stroke, cardiov...
Source: The American Journal of Cardiology - May 30, 2016 Category: Cardiology Authors: Gorm Mørk Hansen, Alexander Egeberg, Palle Holmstrup, Peter Riis Hansen Source Type: research

Relation of Periodontitis to Risk of Cardiovascular and All-Cause Mortality (from a Danish Nationwide Cohort Study)
Periodontitis and atherosclerosis are highly prevalent chronic inflammatory diseases, and it has been suggested that periodontitis is an independent risk factor of cardiovascular disease (CVD) and that a causal link may exist between the 2 diseases. Using Danish national registers, we identified a nationwide cohort of 17,691 patients who received a hospital diagnosis of periodontitis within a 15-year period and matched them with 83,003 controls from the general population. We performed Poisson regression analysis to determine crude and adjusted incidence rate ratios of myocardial infarction, ischemic stroke, cardiovascular...
Source: The American Journal of Cardiology - May 30, 2016 Category: Cardiology Authors: Gorm M ørk Hansen, Alexander Egeberg, Palle Holmstrup, Peter Riis Hansen Tags: Preventive Cardiology Source Type: research

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