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Total 104 results found since Jan 2013.

Incidental Cerebral Microbleeds and Cerebral Hypoperfusion in Cognitively Normal Elderly Individuals (S42.008)
Conclusions: In cognitively normal elderly subjects, incidental cortical CMBs, suggestive of CAA, are associated with widespread reductions in resting state CBF. Chronic hypoperfusion may put individuals at risk for neuronal injury and neurodegeneration. Our results suggest resting state CBF is a marker of CMB-related small vessel disease in cognitively normal elderly individuals. Study supported by: National Institutes of Health grants P50 AG005133 (Drs Lopez and Klunk), R37 AG025516 (Dr Klunk), P01 AG025204 (Dr Klunk), AG041718 (Dr Kamboh), AG030653 (Dr Kamboh), and T32NS048005 (Dr Gurol).Disclosure: Dr. Gregg has nothin...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Gregg, N., Minhas, D., Kim, A., Gurol, E., Lopez, O., Aizenstein, H., Price, J., Mathis, C., James, J., Snitz, B., Cohen, A., Kamboh, M., Weissfeld, L., Tamburo, E., Klunk, W. Tags: Stroke Mechanism and Modifiers Source Type: research

Intra-arterial ALD401 Cell Therapy Is Associated with Reduction in Stroke Volume at 90 Days in a Subset of the RECOVER-Stroke Trial (P6.004)
Conclusions: In this exploratory analysis from one center in the multi-center RECOVER-Stroke trial, intra-arterial stem cell injection with ALD-401 was associated with significant reduction in stroke volume at 90 days post therapy compared to sham procedure in subacute ischemic stroke patients.Disclosure: Dr. Atchaneeyasakul has nothing to disclose. Dr. Dharmadhikari has nothing to disclose. Dr. Sidani has nothing to disclose. Dr. Ramdas has nothing to disclose. Dr. Delgado has nothing to disclose. Dr. Pafford has nothing to disclose. Dr. Huang has received personal compensation for activities with Aldagen/Cytomedix and Da...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Atchaneeyasakul, K., Dharmadhikari, S., Sidani, C., Ramdas, K., Delgado, L., Pafford, R., Huang, D., Hinson, J., Savitz, S., Yavagal, D. Tags: Cerebrovascular Disease and Interventional Neurology Poster Discussion Session Source Type: research

Acute Stroke Educational Video Associated with Improved Stroke Literacy and Increased Patient Satisfaction (P6.012)
Conclusions: A stroke educational video was associated with improved stroke knowledge, certainty in recognizing stroke symptoms and satisfaction with stroke education. A randomized trial is planned.Disclosure: Dr. Denny has nothing to disclose. Dr. Vahidy has nothing to disclose. Dr. Shah has nothing to disclose. Dr. Vu has nothing to disclose. Dr. Sharrief has nothing to disclose. Dr. Savitz has received research support from NIH T32 grant.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Denny, M. C., Vahidy, F., Shah, R., Vu, K. Y. T., Sharrief, A., Savitz, S., Edquilang, G. Tags: Cerebrovascular Disease and Interventional Neurology ePoster Session Source Type: research

Racial and Gender Differences in Tissue Plasminogen Activator Metrics Over Telemedicine (P6.029)
Conclusions: Further investigation is needed to define factors contributing to gender difference in tPA treatment metrics over TM.Disclosure: Dr. Jagolino has nothing to disclose. Dr. Bozorgui has nothing to disclose. Dr. Patel has nothing to disclose. Dr. Irani has nothing to disclose. Dr. Ankrom has nothing to disclose. Dr. Cossey has nothing to disclose. Dr. Sharrief has nothing to disclose. Dr. Vahidy has nothing to disclose. Dr. Savitz has received research support from NIH T32 grant. Dr. Wu has received personal compensation for activities with Genentech.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Jagolino, A., Bozorgui, S., Patel, J., Irani, M., Ankrom, C., Cossey, T., Sharrief, A., Vahidy, F., Savitz, S., Wu, T.-C. Tags: Telestroke and Other Innovations and TIA Source Type: research

Recanalization Therapy of Acute Internal Carotid Artery Occlusion: Comparison of Carotid Endarterectomy and Endovascular Treatment (P6.068)
CONCLUSIONS: Data from this national multicenter registry showed that both CEA and EVT (including bridging therapy) represent safe and effective recanalization methods of acute ICAo. Better clinical outcome was observed in patients without intracranial occlusion and with achieved recanalization. Study Supported by: Internal Grant Agency of Ministry of Health of the Czech Republic grants NT/11046-6/2010, NT/13498-4/2012.Disclosure: Dr. Herzig has nothing to disclose. Dr. Roubec has nothing to disclose. Dr. Skoloudik has nothing to disclose. Dr. Kuliha has nothing to disclose. Dr. Sanak received personal compensation for act...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Herzig, R., Roubec, M., Skoloudik, D., Kuliha, M., Sanak, D., Waishaupt, J., Vitkova, E., Blejcharova, K., Krajickova, D., Tomek, A., Krajina, A., Prochazka, V., Kocher, M., Charvat, F., Fadrna, T., Zapletalova, J., Valis, M. Tags: Cerebrovascular Disease: Miscellaneous Interventions Source Type: research

The Role of Staufen1 in Aberrant RNA Metabolism in SCA2 (P6.396)
Conclusions: Our results unravel a novel function for Staufen1 in aberrant RNA processing events and indicate its role in SCA2 pathogenesis. Our results further support a role for aberrant RNA metabolism in neurodegeneration thereby revealing its potential as a therapeutic target. Study Supported by: This work was supported by Grants RO1NS33123 and RC4NS073009 from the National Institutes of Neurological Disorders and Stroke to SMP.Disclosure: Dr. Paul has nothing to disclose. Dr. Dansithong has nothing to disclose. Dr. Figueroa has nothing to disclose. Dr. Scoles has nothing to disclose. Dr. Pulst has received personal co...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Paul, S., Dansithong, W., Figueroa, K., Scoles, D., Pulst, S. Tags: Movement Disorders: Spinocerebellar Ataxias Source Type: research

Sleep duration is associated with worse neurocognitive function in Hispanic/Latinos: Results of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) (I9-4A)
CONCLUSIONS: Sleep duration had an inverted J-shaped curvilinear association with neurocognitive function, such that those with longer sleep duration had worse neurocognitive scores. Study Supported by: The Hispanic Community Health Study/Study of Latinos was carried out as a collaborative study supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina (N01-HC65233), University of Miami (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235), Northwestern University (N01-HC65236), and San Diego State University (N01-HC65237). The following Institutes/Cent...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Ramos, A., Tarraf, W., Daviglus, M., Davis, S., Gallo, L., Mossavar-Rahmani, Y., Penedo, F., Redline, S., Rundek, T., Sacco, R., Sotres-Alvarez, D., Wright, C., Zee, P., Gonzalez, H. Tags: Treating Dementia in an Age of Mixed Disease Data Blitz Presentations Source Type: research

Differences in Ischaemic and Haemorrhagic Strokes in Sri Lanka: 7-year data from the Ragama Stroke Registry (P1.092)
CONCLUSIONS:Clinical and risk factor profiles were different between ICH and IS patients. Stroke severity and functional disability were higher among ICH patients. Study Supported by:Ragama Stroke Registry has been partly supported by research grants from the University of Kelaniya and Research Institute, International Medical Centre of Japan.Disclosure: Dr. Ranawaka has nothing to disclose. Dr. Peiris has nothing to disclose. Dr. Thirumavalavan has nothing to disclose. Dr. Premawansa has nothing to disclose. Dr. Kasthuriratne has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Ranawaka, U., Peiris, A., Thirumavalavan, K., Premawansa, G., Kasthuriratne, A. Tags: Neuroepidemiology: Cerebrovascular Disease, Critical Care, Epilepsy, Child Neurology, and Sleep Source Type: research

Sleep duration is associated with worse neurocognitive function in Hispanic/Latinos: Results of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) (P1.100)
CONCLUSIONS: Sleep duration had an inverted J-shaped curvilinear association with neurocognitive function, such that those with longer sleep duration had worse neurocognitive scores. Study Supported by: The Hispanic Community Health Study/Study of Latinos was carried out as a collaborative study supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina (N01-HC65233), University of Miami (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235), Northwestern University (N01-HC65236), and San Diego State University (N01-HC65237). The following Institutes/Cent...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Ramos, A., Tarraf, W., Daviglus, M., Davis, S., Gallo, L., Mossavar-Rahmani, Y., Penedo, F., Redline, S., Rundek, T., Sacco, R., Sotres-Alvarez, D., Wright, C., Zee, P., Gonzalez, H. Tags: Neuroepidemiology: Cerebrovascular Disease, Critical Care, Epilepsy, Child Neurology, and Sleep Source Type: research

HDAC4 Shuttling Promotes Neuronal Remodeling After Stroke (I10-1C)
CONCLUSIONS: Stroke induces nuclear shuttling of HDAC4 in excitatory and inhibitory neurons of the peri-infarct cortex which is strongly correlated with enhanced axonal density and myelination, suggesting a role for HDAC4 in promoting neuronal remodeling after stroke. Study Supported by: RO1 AG037506 and NS075156 and AHA Grant 10SDG2790012.Disclosure: Dr. Shehadah has nothing to disclose. Dr. Kassis has nothing to disclose. Dr. Chopp has received personal compensation for activities with EVER Pharmaceutical and Johnson & Johnson. Dr. Roberts has nothing to disclose. Dr. Zhang has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Shehadah, A., Kassis, H., Chopp, M., Roberts, C., Zhang, Z. G. Tags: The Dynamic Brain in Health and Disease: Plasticity and Reprogramming Data Blitz Presentations Source Type: research

Self-reported sleep problems and incidence of dementia (P2.173)
CONCLUSIONS: Our results suggest that increased daytime sleepiness is independent risk factor for dementia in older adults. Study Supported by: WHICAP grant numer:R01AG037212, Felloship in memory of 'Maria Zaousi'Disclosure: Dr. Tsapanou has nothing to disclose. Dr. Gu has nothing to disclose. Dr. Scarmeas has received personal compensation for activities with Novartis. Dr. Stern has received personal compensation for activities with Elan, Bayer Pharmaceuticals Corporation, Cephalon, and GalaxoSmithKlein as a consultant.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Tsapanou, A., Gu, Y., Scarmeas, N., Stern, Y. Tags: Aging, Dementia, Cognitive, and Behavioral Neurology: Memory, Olfaction, and Alzheimer ' s Disease Risk Factors Source Type: research

Carotid Intima-Media Thickness, but neither Framingham Risk Score nor Omnibus Risk Score, is associated with stroke among Nigerian African hypertensive patients (P2.269)
Conclusion: CIMT, but neither FRS nor ORS, is significantly and independently associated with stroke among Nigerian African hypertensive patients. CIMT appears to be a better indicator of stroke than FRS or ORS in this population. Study Partially Supported by:Mac Arthur Grant, University of IbadanDisclosure: Dr. Owolabi has nothing to disclose. Dr. Akpa has nothing to disclose. Dr. Agunloye has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Owolabi, M., Akpa, O., Agunloye, A. Tags: Cerebrovascular Disease and Interventional Neurology: Carotid Disease and IMT Source Type: research

The NINDS Parkinson's Disease Biomarkers Program (P1.194)
Conclusions: The PDBP is a resource with a collection of detailed clinical data and extensive associated biospecimens on subjects with PD and controls. Researchers gain access to the PDBP DMR data by requesting an account. They can subsequently request biospecimens through a straightforward process. More information about requesting an account, ordering biospecimens and more generally, the NINDS PDBP, can be found on the PDBP website (https://pdbp.ninds.nih.gov). For grant mechanisms associated with PDBP, please refer to the following funding opportunity announcements: PAR-14-259 Parkinson's Disease Biomarker Program (PDBP...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Gwinn, K., David, K., Hillaire-Clarke, C., Matt, M., Babcock, D., Sieber, B.-A., Sutherland, M. Tags: Movement Disorders: Parkinson ' s Disease Research Methods Source Type: research

Accuracy of mobile devices for acute stroke head CT interpretation among Neurologists in training. (P1.083)
Conclusions: Among neurologists in training (residents and stroke fellows) mobile devices had good to excellent sensitivity for identification of AIS. Mobile devices also has good to excellent specificity for the identification of the HMCA. Larger studies testing newer generation mobile devices and a greater breadth of findings are needed for comparison with traditional PACs interpretation prior to routine clinical practice.Disclosure: Dr. Khandelwal has nothing to disclose. Dr. Balucani has nothing to disclose. Dr. Steinberg has nothing to disclose. Dr. Weedon has nothing to disclose. Dr. Bulic has nothing to disclose. Dr...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Khandelwal, P., Balucani, C., Steinberg, L., Weedon, J., Bulic, S., Dancour, E., Phillips, K., Escasena, C., Grant, J., Levine, S. Tags: Neuroepidemiology: Cerebrovascular Disease Source Type: research

Coated-platelet levels are associated with stenosis progression in patients with carotid atherosclerosis (I2-5B)
Conclusions: Coated-platelet levels are associated with progression of stenosis severity among patients with carotid atherosclerosis over a 16-month follow-up period. These new prospective findings support a link between elevated coated-platelets and the processes associated with progression of carotid atherosclerosis. Study supported by: grants from the Department of Veterans Affairs: 2011 VISN 16 to Dr. Kirkpatrick and Clinical Science Research & Development Service (Award Number 1I01CX000340) to Dr. Prodan.Disclosure: Dr. Kirkpatrick has nothing to disclose. Dr. Vincent has nothing to disclose. Dr. Nguyen has nothin...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Kirkpatrick, A., Vincent, A., Nguyen, N., Dale, G., Prodan, C. Tags: Management of Asymptomatic Cerebrovascular Lesions Poster Presentations Source Type: research