HDAC4 Shuttling Promotes Neuronal Remodeling After Stroke (I10-1C)

CONCLUSIONS: Stroke induces nuclear shuttling of HDAC4 in excitatory and inhibitory neurons of the peri-infarct cortex which is strongly correlated with enhanced axonal density and myelination, suggesting a role for HDAC4 in promoting neuronal remodeling after stroke. Study Supported by: RO1 AG037506 and NS075156 and AHA Grant 10SDG2790012.Disclosure: Dr. Shehadah has nothing to disclose. Dr. Kassis has nothing to disclose. Dr. Chopp has received personal compensation for activities with EVER Pharmaceutical and Johnson & Johnson. Dr. Roberts has nothing to disclose. Dr. Zhang has nothing to disclose.

Source: Neurology - April 8, 2015 Category: Neurology Authors: Shehadah, A., Kassis, H., Chopp, M., Roberts, C., Zhang, Z. G. Tags: The Dynamic Brain in Health and Disease: Plasticity and Reprogramming Data Blitz Presentations Source Type: research