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Low-dose aspirin and risk of intracranial bleeds: An observational study in UK general practice
Conclusion: Low-dose aspirin is not associated with an increased risk of any type of ICB and is associated with a significantly decreased risk of SAH when used for ≥1 year.
Source: Neurology - November 27, 2017 Category: Neurology Authors: Cea Soriano, L., Gaist, D., Soriano-Gabarro, M., Bromley, S., Garcia Rodriguez, L. A. Tags: All Cerebrovascular disease/Stroke, Case control studies, Risk factors in epidemiology ARTICLE Source Type: research

Population-based study of home-time by stroke type and correlation with modified Rankin score
Conclusions: We showed that home-time is an objective and graded indicator that is correlated with disability after stroke. It is obtainable from administrative data, applicable to different stroke types, and a valuable outcome indicator in population-based health services research.
Source: Neurology - November 6, 2017 Category: Neurology Authors: Yu, A. Y. X., Rogers, E., Wang, M., Sajobi, T. T., Coutts, S. B., Menon, B. K., Hill, M. D., Smith, E. E. Tags: Outcome research, Medical care, Infarction, Intracerebral hemorrhage ARTICLE Source Type: research

Polycystic kidney disease and intracranial aneurysms: Some answers, but many questions remain
Unruptured intracranial aneurysms (UIA) occur in about 2%–3% of the population. Several medical conditions are associated with a UIA presence, including autosomal dominant polycystic kidney disease (ADPKD). Clinicians and patients want to know the risk of aneurysm growth, rupture, or de novo development, predictors of clinical outcomes, and the optimal initial and follow-up screening for individuals with UIA and ADPKD. Such data are unavailable. The recent American Heart Association–American Stroke Association statement on UIAs recommends that patients with familial risk and patients with conditions in which an...
Source: Neurology - October 30, 2017 Category: Neurology Authors: Torner, J. C., Brown, R. D. Tags: EDITORIALS Source Type: research

Polycystic kidney disease among 4,436 intracranial aneurysm patients from a defined population
Conclusions: Subarachnoid hemorrhage occurs at younger age and from smaller IAs in patients with ADPKD and risk for de novo IAs is higher than in the general Eastern Finnish population. ADPKD should be considered as an indicator for long-term angiographic follow-up in patients with diagnosed IAs.
Source: Neurology - October 30, 2017 Category: Neurology Authors: Nurmonen, H. J., Huttunen, T., Huttunen, J., Kurki, M. I., Helin, K., Koivisto, T., von und zu Fraunberg, M., Jääskeläinen, J. E., Lindgren, A. E. Tags: Stroke in young adults, Cohort studies, Subarachnoid hemorrhage, All Genetics ARTICLE Source Type: research

Association of intracranial aneurysm rupture with smoking duration, intensity, and cessation
Conclusions: Current cigarette smoking, smoking intensity, and smoking duration are significantly associated with ruptured IAs at presentation. However, the significantly increased risk persists after smoking cessation, and smoking cessation does not confer a reduced risk of aneurysmal subarachnoid hemorrhage beyond that of reducing the cumulative dose.
Source: Neurology - September 25, 2017 Category: Neurology Authors: Can, A., Castro, V. M., Ozdemir, Y. H., Dagen, S., Yu, S., Dligach, D., Finan, S., Gainer, V., Shadick, N. A., Murphy, S., Cai, T., Savova, G., Dammers, R., Weiss, S. T., Du, R. Tags: All Cerebrovascular disease/Stroke, Subarachnoid hemorrhage ARTICLE Source Type: research

Teaching NeuroImages: RCVS causing simultaneous convexity subarachnoid hemorrhage and hemimedullary infarction
A 34-year-old previously healthy man presented with thunderclap headache, dysphagia, dysarthria, and oscillopsia. Neurologic examination revealed right-beating nystagmus, dysphagia, hypophonia, right hemianesthesia, and left hemiparesis. Brain imaging showed convexity subarachnoid hemorrhage (figure 1A) and left hemimedullary infarct (figure 1B). Catheter angiography showed tapering of left vertebral artery and diffuse segmental vasoconstriction (figure 2). Routine serum and CSF results were unremarkable. Thorough infectious, immunologic, and coagulopathy workup was negative. Reversible cerebral vasoconstriction syndrome (...
Source: Neurology - September 18, 2017 Category: Neurology Authors: Selvan, P., Levine, S. R. Tags: Stroke in young adults, Other cerebrovascular disease/ Stroke, All Cerebrovascular disease/Stroke, Infarction, Subarachnoid hemorrhage RESIDENT AND FELLOW SECTION Source Type: research

Sex-specific stroke incidence over time in the Greater Cincinnati/Northern Kentucky Stroke Study
Conclusions: Decreases in stroke incidence over time are driven by a decrease in ischemic stroke in men. Contrary to previous study periods, stroke incidence rates were similar by sex in 2010. Future research is needed to understand why the decrease in ischemic stroke incidence is more pronounced in men.
Source: Neurology - September 4, 2017 Category: Neurology Authors: Madsen, T. E., Khoury, J., Alwell, K., Moomaw, C. J., Rademacher, E., Flaherty, M. L., Woo, D., Mackey, J., De Los Rios La Rosa, F., Martini, S., Ferioli, S., Adeoye, O., Khatri, P., Broderick, J. P., Kissela, B. M., Kleindorfer, D. Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Incidence studies, Risk factors in epidemiology ARTICLE Source Type: research

A model for predicting the growth of unruptured intracranial aneurysms: Beyond fortune telling
Because of the tremendous initial and long-term morbidity and mortality incurred by intracranial aneurysm rupture, preventive treatment of unruptured intracranial aneurysms is an appealing strategy to prevent subarachnoid hemorrhage (SAH). However, intervention with surgical or endovascular therapy has risk for considerable procedural complications, especially for large or posterior circulation aneurysms.1,2 Therefore, determining the indications for treatment is crucial to optimizing the management of unruptured aneurysms. Approximately 10% to 20% of unruptured aneurysms will enlarge over the first 10 years of follow-up, ...
Source: Neurology - April 24, 2017 Category: Neurology Authors: Ding, D., Etminan, N. Tags: Stroke prevention, Subarachnoid hemorrhage EDITORIALS Source Type: research

Rates and Predictors of 1 year of Readmission with Seizures in Patients with Stroke and Stroke Subtypes: Analysis of a National Cohort of 557,033 Stroke Patients (P2.245)
Conclusions:Rate readmission of seizure after stroke within first year is low and there may be residual confounding by severity. Our findings do not support a need for routine prophylactic anti-epileptic drug use after stroke.Disclosure: Dr. Chaudhry has nothing to disclose. Dr. Chaudhry has nothing to disclose. Dr. Afzal has nothing to disclose. Dr. Gheith has nothing to disclose. Dr. Gu has nothing to disclose. Dr. Saeed has nothing to disclose. Dr. Safdar has nothing to disclose. Dr. Kassab has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Chaudhry, B., Chaudhry, S., Afzal, M.-R., Gheith, T., Gu, S., Saeed, A., Safdar, A., Kassab, M., Qureshi, A. Tags: Epilepsy and Clinical Neurophysiology: Clinical Epilepsy II Source Type: research

Exploring the worth of CTA for ICHUsefulness of CT Angiography in the Diagnosis and Treatment of Intracranial Hemorrhage (P2.263)
Conclusions:Routine CTA after CTH provided little benefit in patients with a hypertensive ICH. CTA after non-hypertensive ICH was especially helpful in patients with subarachnoid hemorrhage, where a treatable underlying vascular abnormality was found in 66.7% of patientsDisclosure: Dr. Alchaki has nothing to disclose. Dr. Gomez has nothing to disclose. Dr. E-Ghanmh has nothing to disclose. Dr. Han has nothing to disclose. Dr. Hillen has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Alchaki, A. R., Gomez, F., El-Ghanem, M., Han, H., Hillen, M. Tags: Intracerebral Hemorrhage Source Type: research

Resumption of Antithrombotic Therapy in LVAD-associated Intracranial Hemorrhages (P2.273)
Conclusions:Among survivors of LVAD-associated ICH, those who resumed both antiplatelet plus warfarin therapy had fewer ischemic, but more hemorrhagic events than those who resumed antiplatelet therapy alone.Disclosure: Dr. Cho has nothing to disclose. Dr. Frontera has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Cho, S.-M., Frontera, J. Tags: Intracerebral Hemorrhage Source Type: research

Neuroimaging Characteristics of Intracranial Hemorrhages and Microhemorrhages in Infective Endocarditis (P2.274)
Conclusions:Intracranial macro- or micro-hemorrhages are seen in 73 (63%) persons with IE. The mortality of intracranial hemorrhage is high but the perioperative stroke risk appears low.Disclosure: Dr. Cho has nothing to disclose. Dr. Marquardt has nothing to disclose. Dr. Zhang has nothing to disclose. Dr. Thatikunta has nothing to disclose. Dr. Uchino has nothing to disclose. Dr. Wisco has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Zhang, L., Cho, S.-M., Marquardt, R., Thatikunta, P., Uchino, K., Wisco, D. Tags: Intracerebral Hemorrhage Source Type: research

The Temporospatial Role of Microcirculatory Dysfunction in the Prediction of Ischemia or Infarction in Patients with Aneurysmal Subarachnoid Hemorrhages (P2.281)
Conclusions:This ongoing study suggests that patients with low mean minimal pulsatility index had poor functional outcomes relative to patients that had higher mean pulsatility index.Study Supported by: This work was supported in part by a grant from the McKnight Brain Research Foundation, Brain and Spinal Cord Injury Research Trust Fund, a grant from NIH National Institute of Neurological Disorders and Stroke, a Medical Student Anesthesia Research Fellowship awarded by the Foundation for Anesthesiology Education and Research, a grant from the Medical Student Research Program at the University of Florida, and the Departmen...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Zamora, A., Gupta, A., Leclerc, J., Vasilopoulos, T., Dore, S. Tags: Subarachnoid Hemorrhage, Intracranial Aneurysm, and Other Cerebrovascular Malformations Source Type: research

Safety of Eptifibatide in Subarachnoid Hemorrhage Patients Requiring Antiplatelet Agents. (P2.285)
Conclusions:Our results indicate that administering IV Eptifibatide to prevent thrombotic complications after endovascular coil embolization in selected patients with aneurysmal subarachnoid hemorrhage is safe. Multicenter prospective trials are warranted to corroborate our findings.Disclosure: Dr. Mehta has nothing to disclose. Dr. Song has nothing to disclose. Dr. DeCarvalho has nothing to disclose. Dr. Z Arango has nothing to disclose. Dr. Kulhari has nothing to disclose. Dr. Kirmani has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Mehta, S., Song, Y.-B., DeCarvalho, B., Arango, A. Z., Kulhari, A., Kirmani, J. F. Tags: Subarachnoid Hemorrhage, Intracranial Aneurysm, and Other Cerebrovascular Malformations Source Type: research

Success of Intravenous Infusion of Verapamil for Refractory Vasospasm in aneurysmal Subarachnoid Hemorrhage (P2.291)
Conclusions:This report indicates that intravenous continuous infusion of verapamil may be used for rescue therapy in transiently responsive cerebral vasospasm to IA verapamil. This therapy did not seem to compromise hemodynamic stability or increase ICP.Disclosure: Dr. Mehta has nothing to disclose. Dr. Kulhari has nothing to disclose. Dr. Z Arango has nothing to disclose. Dr. Suhan has nothing to disclose. Dr. DeCarvalho has nothing to disclose. Dr. Patel has nothing to disclose. Dr. Kirmani has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Mehta, S., Kulhari, A., Arango, A., Suhan, L., DeCarvalho, B., Patel, A., Kirmani, J. F. Tags: Subarachnoid Hemorrhage, Intracranial Aneurysm, and Other Cerebrovascular Malformations Source Type: research

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