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Source: Neurology
Condition: Epilepsy

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Total 139 results found since Jan 2013.

Incidence and management of seizures after ischemic stroke: Systematic review and meta-analysis
Conclusions: The burden of stroke-related seizures and epilepsy due to ischemic stroke is substantial. Further studies are required to determine risk factors for epilepsy following ischemic stroke and optimal secondary prevention.
Source: Neurology - September 18, 2017 Category: Neurology Authors: Wang, J. Z., Vyas, M. V., Saposnik, G., Burneo, J. G. Tags: All Cerebrovascular disease/Stroke, Incidence studies, All Epilepsy/Seizures ARTICLE Source Type: research

Does compensatory hyperparathyroidism predispose to ischemic stroke? Decreased bone mass and increased bone turnover with valproate therapy in adults with epilepsy; An alternative to vitamin D supplementation to prevent fractures in patients with MS; High prevalence of vitamin D deficiency and reduced bone mass in Parkinson's disease
Because of known issues leading to several retractions of papers by Y. Sato et al., the editors of Neurology® have, as a matter of due diligence, researched other papers that this group published in Neurology. To ensure that the scientific literature is correct, the Editor chooses to publish an Expression of Concern regarding 3 observational studies and a Letter to the Editor published in Neurology prior to the retracted clinical trials.1–4
Source: Neurology - September 18, 2017 Category: Neurology Tags: EXPRESSION OF CONCERN Source Type: research

Sudden unexpected death in epilepsy patients is often misdiagnosed as sudden cardiac death
Sudden unexpected death in epilepsy patients (SUDEP) represents the second main neurologic cause of years of potential life lost, following stroke, with a cumulative lifetime risk reaching 8% for childhood-onset epilepsy.1 In light of these worrying figures, the American Academy of Neurology (AAN) has recently published practice guidelines on the risk of SUDEP. These guidelines emphasize the "considerable uncertainty"of SUDEP incidence in adults with epilepsy, currently estimated at 1.2/1,000 patient-years (95% CI 0.64–2.32).2 Difficulties in assessing the epidemiology of SUDEP are several, including large variation ...
Source: Neurology - August 28, 2017 Category: Neurology Authors: Ryvlin, P., Cascino, G. D. Tags: All Epilepsy/Seizures EDITORIALS Source Type: research

Clinical Reasoning: A 61-year-old man with conjugate gaze deviation, hemiparesis, and asymmetric reflexes
A 61-year-old man with a history of alcoholic cirrhosis was transferred from an outside hospital for spontaneous bacterial peritonitis, septic shock, and respiratory failure after intubation. The patient was initially on sedation; however, more than 48 hours after the sedative was discontinued, his mental status remained depressed and he also developed new onset of conjugate rightward gaze deviation. On neurologic examination, the patient was unresponsive to verbal stimuli and sternal rub. He could not follow any command, including closing or opening eyes and squeezing hands. He had remarkable conjugate, forced eye deviati...
Source: Neurology - August 28, 2017 Category: Neurology Authors: Lin, C.-Y., Yoo, J. Y., Doshi, A., Colman, R. Tags: MRI, Clinical neurology examination, All Cerebrovascular disease/Stroke, Critical care, Video/ EEG use in epilepsy RESIDENT AND FELLOW SECTION Source Type: research

Hospital safety among neurologic patients: A population-based cohort study of adverse events
Conclusions: This study demonstrates that neurologic patients have a high proportion of AEs in hospital. The findings provide information on the quality and safety of care for people with neurologic conditions in hospital, which can help inform future quality improvement initiatives.
Source: Neurology - July 17, 2017 Category: Neurology Authors: Sauro, K. M., Quan, H., Sikdar, K. C., Faris, P., Jette, N. Tags: All Health Services Research, Medical care, All Clinical Neurology, Patient safety ARTICLE Source Type: research

SUDEP: An important cause of premature mortality in epilepsy across the life spectrum
Sudden unexpected death in epilepsy (SUDEP) was originally defined as a sudden, unexpected death in an individual with epilepsy, witnessed or not, and not associated with drowning or status epilepticus, for which a cause cannot be identified upon autopsy examination.1 Cases can be divided into definite, probable, and possible based upon the level of diagnostic certainty, especially after postmortem examination.2 As research criteria have evolved, a more comprehensive set of diagnostic criteria has been derived, including the term plus to indicate that another cause could have resulted in death, e.g., SUDEP probable/plus.3 ...
Source: Neurology - July 10, 2017 Category: Neurology Authors: Buchhalter, J., Cascino, G. D. Tags: EDITORIALS Source Type: research

Rates and Predictors of 1 year of Readmission with Seizures in Patients with Stroke and Stroke Subtypes: Analysis of a National Cohort of 557,033 Stroke Patients (P2.245)
Conclusions:Rate readmission of seizure after stroke within first year is low and there may be residual confounding by severity. Our findings do not support a need for routine prophylactic anti-epileptic drug use after stroke.Disclosure: Dr. Chaudhry has nothing to disclose. Dr. Chaudhry has nothing to disclose. Dr. Afzal has nothing to disclose. Dr. Gheith has nothing to disclose. Dr. Gu has nothing to disclose. Dr. Saeed has nothing to disclose. Dr. Safdar has nothing to disclose. Dr. Kassab has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Chaudhry, B., Chaudhry, S., Afzal, M.-R., Gheith, T., Gu, S., Saeed, A., Safdar, A., Kassab, M., Qureshi, A. Tags: Epilepsy and Clinical Neurophysiology: Clinical Epilepsy II Source Type: research

Late treatment with choline alfoscerate increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment (P1.229)
Conclusions:The present study suggests that application of α-GPC after seizure may serve as a beneficial treatment for improvement of cognitive function in epilepsy patientsDisclosure: Dr. Yoo has nothing to disclose. Dr. Shin has nothing to disclose. Dr. Lee has nothing to disclose. Dr. SONG has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Yoo, J., Shin, D. J., Lee, B., SONG, H. Tags: Epilepsy and Clinical Neurophysiology: Basic Science Source Type: research

Increased Epilepsy Prevalence in Adults with 22q11 Deletion Syndrome (P1.236)
Conclusions:The prevalence of provoked seizures in adults with 22q11.2DS is higher than in the general population. Hypocalcemia continues to be risk factor for adults, but differently from children, adults with 22qDS are more exposed to psychotropic medications and are more vulnerable to seizures caused by them compared to the general population. These patients are also more likely to develop genetic generalized and focal epilepsy, structural epilepsy (due to malformation of cortical development, trauma, stroke). Further prospective studies are warranted to investigate how 22q11.2 microdeletion leads to an overall decrease...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Wither, R., MacDonald, A., Borlot, F., Butcher, N., Chow, E., Bassett, A., Andrade, D. Tags: Epilepsy and Clinical Neurophysiology: Genetics Source Type: research

Misdiagnosis of CADASIL: A single Medical Center experience (P1.251)
Conclusions:CADASIL is the most prevalent monogenic cerebral small-vessel arteriopathy. Despite wide availability of genetic testing, misdiagnosis and delay diagnosis are common. We encourage for enhanced awareness of CADASIL among patients with migraines with aura, recurrent TIAs or subcortical ischemic strokes, and mood disorder, in order to provide appropriate multidisciplinary treatment, psychological support and genetic counselingStudy Supported by: n/aDisclosure: Dr. Ortiz-Garcia has nothing to disclose. Dr. Orjuela has nothing to disclose. Dr. Sweis has nothing to disclose. Dr. Biller has received personal compensat...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Ortiz-Garcia, J., Orjuela, K., Sweis, R., Biller, J. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research

Limb-Shaking TIA as the Presenting Symptom of ICA Dissection (P3.269)
Conclusions:This case demonstrates limb-shaking TIA as the presenting symptom of ICA dissection. Neurologists should be aware that involuntary limb movements in the setting of ICA dissection with associated borderzone ischemia can represent limb-shaking TIA. Broadening the differential will increase appropriate diagnostic testing and proper treatment.Disclosure: Dr. LaBoy has nothing to disclose. Dr. Mannel has nothing to disclose. Dr. Silliman has received research support from Sanofi Genzyme, Biogen Idec, Bristol Myers and Novartis.
Source: Neurology - April 17, 2017 Category: Neurology Authors: LaBoy, S., Mannel, R., Silliman, S. Tags: Cerebrovascular Disease Case Reports II Source Type: research

Acute ischemic stroke in a young female: a novel presentation of anti-GAD autoimmunity (P3.272)
Conclusions:Restricted diffusion, seen typically in ischemia, indicates cytotoxic oedema and irreversible cell damage. In this patient, we postulate a mechanism of severe CNS inflammation with cellular toxicity and small vessel vasculitis. Anti-GAD autoimmunity should be considered in young patients presenting with stroke-like episodes, particularly when accompanied by positive phenomenon.Disclosure: Dr. Neo has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Lee has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Neo, X. S., Lee, K. E., Lee, R. Tags: Cerebrovascular Disease Case Reports II Source Type: research

Utilization and Cost Savings of Neuroscience Telemedicine Clinic for State Prison Inmates (P2.182)
Conclusions:General neurology/neurosurgical telemedicine-based clinics can serve the broad spectrum of neuroscience diseases present in the prison system, while minimizing costly and potentially dangerous transfers.Disclosure: Dr. Majersik, MD, MS has nothing to disclose. Dr. Fults, MD has nothing to disclose. Dr. diFrancesco, RN has nothing to disclose. Dr. Wong has nothing to disclose. Dr. Chatwin, MPP has nothing to disclose. Dr. Hannon, MD has nothing to disclose. Dr. Tkach, MD has nothing to disclose. Dr. Shuman III, RN has nothing to disclose. Dr. Bernam, MD has nothing to disclose. Dr. Garden, MD has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Majersik, J., Fults, D., diFrancesco, E., Wong, K.-H., Chatwin, S., Hannon, P., Tkach, A., Shuman, H., Bernam, B., Garden, R. Tags: General Neurology: Practice Improvement and Novel Approaches to Care Source Type: research

Fetal central nervous system malformations: a ten year review of prenatal consultations at a tertiary care center (P4.150)
Conclusions:Neurodevelopmental outcomes ranged over a wide spectrum. Prenatal counseling includes cautious consideration of parental expectations, available long-term data on neurodevelopment and functional outcomes, limitations of neuroimaging and genetic testing, and critical decision making from both clinicians and families. This study aims to develop a standardized and comprehensive approach for fetal neurologic prognostication for neurodevelopmental outcomes, and for timely decision making in the prenatal and postnatal period.Disclosure: Dr. Agarwal has nothing to disclose. Dr. Keller has nothing to disclose. Dr. Clar...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Agarwal, S., Keller, J., Clark, G., Emrick, L. Tags: Child Neurology II Source Type: research

Common etiologies of acute symptomatic seizures evolving from lateralized periodic discharges in patients monitored with continuous EEG (P2.233)
Conclusions:The most common high risk etiologies of acute symptomatic seizures evolving from lateralized periodic discharges in our cohort of patients were ischemic stroke, tumor, encephalitis, and subdural hematoma. Recognition of these etiologic factors may influence the duration of continuous EEG monitoring employed or the decision to institute seizure prophylaxis. A larger cohort of patients should be reviewed in a future study to confirm these findings.Disclosure: Dr. Mathew has nothing to disclose. Dr. Piran has nothing to disclose. Dr. Hantus has received personal compensation for activities with UCB Pharma as a con...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Mathew, S., Piran, P., Hantus, S., Malpe, C. Tags: Epilepsy and Clinical Neurophysiology: EEG and Imaging Source Type: research