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Global trends in perioperative stroke research from 2003 to 2022: a web of science-based bibliometric and visual analysis
ConclusionPublications regarding perioperative stroke have experienced rapid growth in the past 20 years and are likely to continuously increase. Research on perioperative antiplatelet and antithrombotic, cardiovascular surgery, postoperative cognitive dysfunction, thrombectomy, tranexamic acid, and frozen elephant trunk has attracted increasing attention, and these topics are emerging hotspots of present research and possible candidates for future research.
Source: Frontiers in Neurology - May 31, 2023 Category: Neurology Source Type: research

Global research trends on COVID-19 and stroke: A bibliometric analysis
ConclusionOur bibliometric analysis provides a comprehensive overview of the current state of research on COVID-19 and stroke and highlights key areas of focus in the field. Optimizing the treatment of COVID-19-infected stroke patients and elucidating the underlying pathogenic mechanisms of COVID-19 and stroke co-morbidity are key areas of future research that will be beneficial in improving the prognosis of stroke patients during the ongoing COVID-19 epidemic.
Source: Frontiers in Neurology - April 3, 2023 Category: Neurology Source Type: research

Decreased CSF Levels of ß-Amyloid in Patients With Cortical Superficial Siderosis
Conclusions: Our results demonstrate that the presence and extent of cSS are associated with reduced CSF ß-amyloid 42 levels. Further studies are needed to investigate the underlying mechanisms of this association. Introduction Cerebral amyloid angiopathy (CAA)—characterized by the deposition of ß-amyloid in the walls of leptomeningeal vessels—is a common cerebral small vessel disease and a major cause of intracerebral hemorrhage in the elderly (1–3). Furthermore, it has become evident that CAA is associated with cognitive impairment (4). Specifically, it has been shown that ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

A Novel Homozygous Non-sense Mutation in the Catalytic Domain of MTHFR Causes Severe 5,10-Methylenetetrahydrofolate Reductase Deficiency
Conclusion: We identified a novel non-sense mutation in MTHFR gene in a single Egyptian family with severe MTHFR deficiency. The present investigation is clinically important, as it adds to the growing list of MTHFR mutations, which might help in genetic counseling of families of affected children and proper genotype-phenotype correlation. Background Severe 5,10-Methylenetetrahydrofolate reductase (MTHFR; OMIM 236250) deficiency is a rare inborn error of metabolism and inherited in an autosomal recessive fashion. It is a very common disorder of folate metabolism and is clinically characterized with low plasma methion...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Beta Amyloid Deposition Is Not Associated With Cognitive Impairment in Parkinson's Disease
In this study, we used a well-validated visual assessment to clinically rate scans as being amyloid positive or negative (38). As there is not an accepted threshold based on standardized centiloid reference regions, we defined an amyloid positivity centiloid cut-off threshold in our sample. Our cut-off (CL = 31.3, SUVR = 1.21) corresponds well to the estimated value proposed by Rowe and colleagues (34) in the context of AD (CL = 25–30), however our estimated threshold may be biased by the low number of Aβ positive patients. Our results suggest a lower prevalence of amyloid-positive PDD individuals than in ...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Post-Stroke Disability at a National Referral Hospital in Tanzania (P3.322)
Conclusions:In this low-resource setting, individuals with stroke face a severe burden of disability and high risk of mortality. The majority of participants experienced severe deficits following stroke, as assessed through NIHSS and mRS. While this study may be limited by referral bias, the high toll of disability among this population suggests that post-stroke disability places a significant burden on Tanzanian families and society.Study Supported by:This abstract was made possible with help from the Harvard University Center for AIDS Research (CFAR), an NIH funded program (P30 AI060354), subgrant to F. Mateen.Disclosure...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Wibecan, L., Mmbando, T., Grundy, S., Klein, J., Mateen, F., Okengo, K. Tags: Global Health Source Type: research

A Brief Dementia Screening Test in South Africa: Results from the Health and Aging Longitudinal Study of an INDEPTH community (HAALSI) (P4.191)
Conclusions:There is a potentially protective and long-lasting impact of secondary school education on cognitive status later in life in this setting. Using a brief screening test in this relatively poor cohort of older South Africans, patterns of low cognition are similar to those in the USA and other countries.Study Supported by:The National Institute on Aging at the National Institute of Health (NIH) (1P01AG041710-01A1; 1R01AG051144–01; 3U54HG006938-03S1). F. Mateen is supported by a subgrant of P30AG024409 from the NIH for the Harvard Center for Global Demography and Aging. The Agincourt HDSS was supported by the...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Mateen, F., Jennings, E., Montana, L., Wagner, R., Kahn, K., Tollman, S., Berkman, L. Tags: Behavioral and Cognitive Neurology: Neurodegenerative Disorders Source Type: research

Striatal and Extrastriatal Dopamine Transporter Levels Relate to Cognition in Lewy Body Diseases (P2.009)
CONCLUSIONS: Caudate and extrastriatal dopamine dysfunction contribute in opposing directions to cognitive impairment in DLB.Study Supported by: Michael J. Fox Foundation (SNG, JHG.), National Alzheimer’s Coordinating Center Collaborative Project 5 U01 AG016976-11 (SNG, KAJ, JHG), the National Institute of Neurological Disorders and Stroke (KAJ), the National Institute on Aging (KAJ,TH), the Alzheimer’s Disease Association (KAJ), the Caja Madrid Foundation scholarship for postgraduate studies (MM), the Harvard Center for Neurodegeneration and Repair Pilot grant (SNG). Randy L. Buckner contributed to this study:...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Gomperts, S., Marquie Sayagues, M., Locascio, J., Rentz, D., Becker, A., Hedden, T., Johnson, K., Growdon, J. Tags: Movement Disorders II Source Type: research

Factor VIII as a Predictor of Stroke Etiology (P1.115)
CONCLUSIONS:Cohort characteristics differed significantly by pFVIII levels. Mean pFVIII level differed across TOAST etiologies, with "Other" etiology strokes consistently reporting elevated pFVIII levels, significantly different from reference. Our analysis suggests that pFVIII potentially serves as a novel clinical characteristic for appropriately classifying TOAST subgroups, which thereby may potentially inform appropriate secondary stroke prevention.Disclosure: Dr. Halstead has nothing to disclose. Dr. Yeh has nothing to disclose. Dr. Schluter has nothing to disclose. Dr. Monlezun, Jr has nothing to disclose. Dr. George...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Halstead, M., Yeh, A., Schluter, L., Monlezun, D., George, A., Schild, C., El Khoury, R., Martin-Schild, S. Tags: Cerebrovascular Disease and Interventional Neurology: Antiplatelet Agents and Miscellaneous Source Type: research

Gender and Dopaminergic Medication Treatment in Early Parkinson Disease (P3.069)
CONCLUSIONS: Although we did not observe gender differences in the type and dose of dopaminergic treatment in LS-1 participants with early PD, further research is needed to evaluate gender influences on dopaminergic medication treatment in mid- and late-stage PD.Study Supported by: on behalf of the NET-PD LS1 investigators.Disclosure: Dr. Umeh has nothing to disclose. Dr. Pérez has nothing to disclose. Dr. Augustine has nothing to disclose. Dr. Dhall has received personal compensation for activities with UCP Pharma, Impax Pharmaceuticals, and Teva Neuroscience. Dr. Dewey has received personal compensation for activi...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Umeh, C., Perez, A., Augustine, E., Dhall, R., Dewey, R., Mari, Z., Simon, D., Wills, A. M., Christine, C., Schneider, J., Suchowersky, O. Tags: Movement Disorders: Clinical Features of Parkinson ' s Disease Source Type: research

Delaying dementia: Can antihypertensives prevent Alzheimer dementia?
Oliver Wendell Holmes, Sr., a 19th-century physician, Dean of Harvard Medical School, and poet, described an enchanting thought experiment in his poem, "The Deacon's Wonderful One-Hoss Shay." This carriage was crafted to be equally strong in every part, letting it run in perfect condition for a 100 years before, one fine day, it disintegrated like a "bubble burst." For many geriatric neurologists and their patients, that would be a worthy goal: to address all the "weak links," the most vulnerable and fixable aspects of brain aging, thus compressing morbidity due to cognitive decline into a brief flicker prior to death. The...
Source: Neurology - September 2, 2013 Category: Neurology Authors: Seshadri, S. Tags: All Cognitive Disorders/Dementia EDITORIALS Source Type: research