Beta Amyloid Deposition Is Not Associated With Cognitive Impairment in Parkinson's Disease

Beta Amyloid Deposition Is Not Associated With Cognitive Impairment in Parkinson's Disease Tracy R. Melzer1,2,3†, Megan R. Stark1,2†, Ross J. Keenan1,4, Daniel J. Myall1, Michael R. MacAskill1,2, Toni L. Pitcher1,2,3, Leslie Livingston1,2, Sophie Grenfell1, Kyla-Louise Horne1,2, Bob N. Young1, Maddie J. Pascoe1, Mustafa M. Almuqbel1,2,4, Jian Wang5, Steven H. Marsh6, David H. Miller1,2,7, John C. Dalrymple-Alford1,2,3,8 and Tim J. Anderson1,2,3,9* 1New Zealand Brain Research Institute, Christchurch, New Zealand 2Department of Medicine, University of Otago, Christchurch, New Zealand 3Brain Research New Zealand Rangahau Roro Aotearoa Centre of Research Excellence, Christchurch, New Zealand 4Pacific Radiology Group, Christchurch, New Zealand 5Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China 6Department of Physics and Astronomy, University of Canterbury, Christchurch, New Zealand 7Institute of Neurology, University College London, London, United Kingdom 8Department of Psychology, University of Canterbury, Christchurch, New Zealand 9Department of Neurology, Christchurch Hospital, Christchurch, New Zealand The extent to which Alzheimer neuropathology, particularly the accumulation of misfolded beta-amyloid, contributes to cognitive decline and dementia in Parkinson's disease (PD) is unresolved. Here, we used Florbetaben PET imaging to test for any association between cerebral amyloid deposition and cognitive...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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Abstract Identification of tyrosine Fyn kinase inhibitor is recognized as an effective and feasible therapeutic measure in reducing consequences of memory loss disorder Alzheimer's. The present investigation has been attempted with an objective to find out a novel potent inhibitor with similar homological structure to Fyn kinase using structure based in silico screening measure. Such derived structure was compared with natural data base pool and were systematically analyzed. Ligand based interaction was also tested and evaluated. We applied a molecular dynamic simulation technique to validate the stability of the ...
Source: Bioinformation - Category: Bioinformatics Authors: Tags: Bioinformation Source Type: research
Conclusion: The presented method does not require a learning stage and enables a duty cycle close to 100%, higher average acoustic intensity and avoidance of side lobe effects versus performing HIFU beam steering to compensate tissue motion. Significance: To our knowledge, the proposed method provides the first experimental validation of the self-scanning HIFU ablation paradigm via a real-time hybrid MRI/US imaging, opening the path toward self-scanning in vivo therapies.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
The objective of this paper is to investigate the detectability of breast tumors having various histological types in excised breast tissues of total mastectomy. The tumor images measured by a portable impulse-radio-ultra-wideband (IR-UWB)-radar-based breast cancer detector are compared with both pathological images and images of dedicated breast positron emission tomography. It is found that the detector can detect invasive-ductal-carcinomas and extensive intraductal component in the dense breast. The density of the breast has a correlation to the effective permittivity derived from the reconstructed confocal images. The ...
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Conclusion and Significance: This system has the capability to operate within the strong magnetic field of a clinical 3-T MRI, to form proper particle aggregates and to automatically inject these aggregates into the MRI bore. Moreover, the versatility of the proposed injector renders it suitable for selective injections of MDEBs during MR-guided embolization procedures.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
The neuroimaging-based computer-aided diagnosis for Parkinson's disease (PD) has attracted considerable attention in recent years, where the classifier plays a critical role. Random vector functional link network (RVFL) has shown its effectiveness for classification task, while its extended version, namely RVFL plus (RVFL+), integrates the additional privileged information (PI) about training samples in RVFL to help training a more effective classifier. On the other hand, it is still a popular way to adopt only a single neuroimaging modality for PD diagnosis in a clinical practice. In this work, we construct a novel...
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Objective: In the past decade, cognitive training tools have been used to improve brain functioning, and some have been applied to cognitive decline in dementia. Recently, research studies have demonstrated that aerobic exercise could play an important restorative role toward cognitive impairments. Therefore, the main objective of this paper is to present the innovative use of the SmartWalk tool, which combines aerobic exercise and cognitive protocols traditionally used to stimulate cognitive function. Methods: The primary goal of this study to demonstrate if our tool is correlated with traditional computerized test in sti...
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Publication date: Available online 18 July 2019Source: International Review of NeurobiologyAuthor(s): T. Fernández-Valle, I. Gabilondo, J.C. Gómez-EstebanAbstractParkinson's disease (PD) is the second most prevalent neurodegenerative disorder. It is characterized by a slow and progressive loss of dopaminergic neurons.Its neuropathological hallmark is the accumulation of aggregated form of α-synuclein (α-syn) protein in intracellular inclusions known as Lewy bodies. This aggregated α-syn is believed to be central to the pathogenesis of PD. Emerging evidence suggests that aggregated forms of &...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Publication date: Available online 18 July 2019Source: International Review of NeurobiologyAuthor(s): Sergio Vegas-Suarez, Elena Paredes-Rodriguez, Asier Aristieta, Jose V. Lafuente, Cristina Miguelez, Luisa UgedoAbstractParkinson's disease (PD) is characterized by the degeneration of dopaminergic neurons in the substantia nigra, the depletion of striatal dopamine and the presence of Lewy aggregates containing alpha-synuclein. Clinically, there are motor impairments involving cardinal movement symptoms, bradykinesia, resting tremor, muscle rigidity, and postural abnormalities, along with non-motor symptoms such as sleep, b...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Publication date: Available online 18 July 2019Source: International Review of NeurobiologyAuthor(s): Dafin Fior Muresanu, Aruna Sharma, Ranjana Patnaik, Preeti K. Menon, Herbert Mössler, Hari Shanker SharmaAbstractThere is a growing trend of hypertension among military and civilian populations due to lifetime stressful situations. If hypertension is uncontrolled it leads to development of diabetes and serious neurological complications. Most of the World populations live in temperate zone across the World. Thus, a possibility exists that these hypertensive and diabetic people may have external heat as potential risk ...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
In this study, we apply a diffusion “signal” model (diffusion tensor imaging, DTI) and two commonly implemented “microstructural” models (neurite orientation dispersion and density imaging, NODDI; spherical mean technique, SMT) in the human cervical spinal cord of twenty-one healthy controls. We first provide normative values of DTI, SMT, and NODDI indices in a number of white matter ascending and descending pathways, as well as various gray matter regions. We then aim to validate the sensitivity and specificity of these diffusion-derived contrasts by relating these measures to indices of the tissue...
Source: NeuroImage - Category: Neuroscience Source Type: research
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