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Total 122 results found since Jan 2013.
Idaho mom goes the distance to help teen with scoliosis
“You want a hospital with the best technology and the best nurses and doctors in the country. You expect that, and you expect it to be clean. Boston Children’s has all of that,” says Lisa Findlay, a mom from Hayden, Idaho.
“What made the difference was how much everyone loves these kids. Everyone who walked into Aaron’s room, from the surgeons to nurses’ aides to janitors and child life specialists, was on a mission to help Aaron.”
From the time he was born, Aaron encountered one medical challenge after another.
He was born with hypoplastic left heart syndrome (HLHS), a serious congenital heart defect. By...
Source: Thrive, Children's Hospital Boston - April 2, 2015 Category: Pediatrics Authors: Lisa Fratt Tags: Orthopedics Our patients’ stories Source Type: news
Anaesthetic management of transcatheter aortic valve implantation: results from the Italian CoreValve registry.
CONCLUSIONS: Our study indicates that, in experienced centres which have gone beyond their initial learning curve with TAVI, the use of local anaesthesia in a selected patient population can be associated with good clinical outcomes. Nevertheless, as severe procedural complications are possible, an anaesthesiologist should always be present as part of the team.
PMID: 25772903 [PubMed - as supplied by publisher]
Source: EuroIntervention - March 20, 2015 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
Rare platelet GPCR variants: what can we learn?
Platelet‐expressed GPCRs are critical regulators of platelet function. Pharmacological blockade of these receptors forms a powerful therapeutic tool in the treatment and prevention of arterial thrombosis associated with coronary atherosclerosis and ischaemic stroke. However, anti‐thrombotic drug therapy is associated with high inter‐patient variability in therapeutic response and adverse bleeding side effects. In order to optimize the use of existing anti‐platelet drugs and to develop new therapies, more detailed knowledge is required relating to the molecular mechanisms that regulate GPCR and therefore platelet fu...
Source: British Journal of Pharmacology - November 24, 2014 Category: Drugs & Pharmacology Authors: S P Nisar, M L Jones, M R Cunningham, A D Mumford, S J Mundell, Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research
Blunt traumatic injury of the innominate artery resulting in a stroke – A rare presentation
We present a case of traumatic injury of the innominate artery resulting in an ischemic stroke. Case presentation A 20-year-old gentleman ejected from a two wheeler and run over by a truck presented to us with multiple bleeding facial wounds and severe crush injury of his upper torso. Bedside chest X-ray revealed a widened mediastinum and multiple rib fractures with pneumothoraces bilaterally which were drained with intercostal tubes. An hour into his stay in the ED he developed left hemiparesis. CT brain showed infarcts in right temporo-parietal and occipital regions. CT angiogram of neck vessels revealed an avulsion inj...
Source: Apollo Medicine - October 23, 2014 Category: Journals (General) Source Type: research
Rare platelet G protein‐coupled receptor variants: What Can We Learn?
Summary
Platelet expressed G protein‐coupled receptors (GPCRs) are critical regulators of platelet function. Pharmacological blockade of these receptors forms a powerful therapeutic tool in the treatment and prevention of arterial thrombosis associated with coronary atherosclerosis and ischaemic stroke. However, anti‐thrombotic drug therapy is associated with high inter‐patient variability in therapeutic response and adverse bleeding side‐effects. In order to optimise the use of existing antiplatelet drugs and to develop new therapies more detailed knowledge is required relating to the molecular mechanisms that reg...
Source: British Journal of Pharmacology - September 18, 2014 Category: Drugs & Pharmacology Authors: S. P. Nisar, M L Jones, M R Cunningham, A D Mumford, S J Mundell, Tags: Review Article – 5th BPS Focused Meeting on Cell Signalling Themed Issue Source Type: research
Transition From Blinded Study Drug to Open-LabelTransition From Blinded Study Drug to Open-Label
Learn about an end-of-trial transition plan to minimize bleeding and stroke risks during a critical period. Journal of the American College of Cardiology
Source: Medscape Today Headlines - September 8, 2014 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news
Learning More From the Dabigatran Concentrations in the RE-LY Study
We read with great interest the paper by Reilly et al. (1), which demonstrated that higher trough plasma dabigatran concentrations were associated with: 1) decreasing risk of stroke/systemic embolic event (SEE); and 2) increasing major bleeding risk in the RE-LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) trial (2). The paper provides useful insights into the relationship between dabigatran exposure and clinical events but raises several questions.1.Time lag from blood samples to events.
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - June 16, 2014 Category: Cardiology Source Type: research
Dabigatran Concentrations and Ischemic Stroke in AFDabigatran Concentrations and Ischemic Stroke in AF
Learn more on how ischemic stroke and bleeding outcomes are tied to dabigatran plasma concentrations. Journal of the American College of Cardiology
Source: Medscape Today Headlines - March 6, 2014 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news
Are you bleeding? Validation of a machine-learning algorithm for determination of blood volume status: application to remote triage
In conclusion, a machine-learning algorithm developed from low-level physiological signals could reliably distinguish central hypovolemia from exercise, indicating that this device could provide battlefield remote triage capabilities.
Source: Journal of Applied Physiology - March 1, 2014 Category: Physiology Authors: Rickards, C. A., Vyas, N., Ryan, K. L., Ward, K. R., Andre, D., Hurst, G. M., Barrera, C. R., Convertino, V. A. Tags: ARTICLES Source Type: research
Reperfusion therapy of acute ischaemic stroke and acute myocardial infarction: similarities and differences
The evolution of reperfusion therapy in acute myocardial infarction and acute ischaemic stroke has many similarities: thrombolysis is superior to placebo, intra-arterial thrombolysis is not superior to intravenous (i.v.), facilitated intervention is of questionable value, and direct mechanical recanalization without thrombolysis is proven (myocardial infarction) or promising (stroke) to be superior to thrombolysis—but only when started with no or minimal delay. However, there are also substantial differences. Direct catheter-based thrombectomy in acute ischaemic stroke is more difficult than primary angioplasty (in S...
Source: European Heart Journal - January 14, 2014 Category: Cardiology Authors: Widimsky, P., Coram, R., Abou-Chebl, A. Tags: ESC 2013 Andreas Gr[uuml ]ntzig Lecture Source Type: research
Significance of the learning curve in left atrial appendage occlusion with two different devices
Conclusions: Complications associated with LAA occlusion cluster early in the periprocedural period and significantly decrease in frequency with operator experience. Initial experience gained with one of device may improve outcome with use of alternative LAA occlusion devices. © 2013 Wiley Periodicals, Inc.
Source: Catheterization and Cardiovascular Interventions - October 6, 2013 Category: Cardiovascular & Thoracic Surgery Authors: I. Cruz‐Gonzalez, A Perez‐Rivera, R Lopez‐Jimenez, J Rodriguez‐Collado, J Martín‐Moreiras, M Cascon, A. Arribas, J.C. Gomez, Andrew O Maree, C Martin‐Luengo Tags: Original Studies Source Type: research
337-i * thoracoscopic left atrial appendectomy
Conclusions: This approach demonstrated feasibility, safety and effectiveness and should be considered as a possible alternative to percutaneous closure of the LAA. However, its effect on long-term prevention of stroke needs to be evaluated.
Source: Interactive CardioVascular and Thoracic Surgery - September 18, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Guerra, M., Miranda, J., Martins, D., Neves, P., Gama, V., Vouga, L. Tags: Learning from experience (film) Source Type: research
EHRA Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation: executive summary
New oral anticoagulants (NOACs) are an alternative for vitamin K antagonists (VKAs) to prevent stroke in patients with non-valvular atrial fibrillation (AF). Both physicians and patients will have to learn how to use these drugs effectively and safely in specific clinical situations. This text is an executive summary of a practical guide that the European Heart Rhythm Association (EHRA) has assembled to help physicians in the use of the different NOACs. The full text is being published in EP Europace. Practical answers have been formulated for 15 concrete clinical scenarios: (i) practical start-up and follow-up scheme for ...
Source: European Heart Journal - July 14, 2013 Category: Cardiology Authors: Heidbuchel, H., Verhamme, P., Alings, M., Antz, M., Hacke, W., Oldgren, J., Sinnaeve, P., Camm, A. J., Kirchhof, P. Tags: SPECIAL ARTICLE Source Type: research
The Transaortic Approach for Transcatheter Aortic Valve Replacement Initial Clinical Experience in the United States
ConclusionsTAVR via the TAO approach is technically feasible, seems to be associated with favorable outcomes, and expands the current alternative options for access sites in patients with inoperable aortic stenosis who are ineligible for TF TAVR.
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - June 3, 2013 Category: Cardiology Source Type: research
European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation
New oral anticoagulants (NOACs) are an alternative for vitamin K antagonists (VKAs) to prevent stroke in patients with non-valvular atrial fibrillation (AF). Both physicians and patients will have to learn how to use these drugs effectively and safely in clinical practice. Many unresolved questions on how to optimally use these drugs in specific clinical situations remain. The European Heart Rhythm Association set out to coordinate a unified way of informing physicians on the use of the different NOACs. A writing group listed 15 topics of concrete clinical scenarios and formulated as practical answers as possible based on ...
Source: Europace - April 26, 2013 Category: Cardiology Authors: Heidbuchel, H., Verhamme, P., Alings, M., Antz, M., Hacke, W., Oldgren, J., Sinnaeve, P., Camm, A. J., Kirchhof, P. Tags: EHRA PRACTICAL GUIDE Source Type: research
