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Impaired Activity of Ryanodine Receptors Contributes to Calcium Mishandling in Cardiomyocytes of Metabolic Syndrome Rats
Conclusion Principal findings of this work are that abnormal Ca2+ transient amplitude, contractile dysfunction; and impaired relaxation of MetS cardiomyocytes underlies intrinsic dysfunctional RyR2 and SERCA pump. Abnormal activity of RyRs was evidenced by its decreased ability to bind [3H]-ryanodine. Although the MetS condition does not modify RyR2 protein expression, its phosphorylation at Ser2814 is decreased, which impairs its capacity for activation during ECC. The dysfunctional RyRs, together with a decreased activity of SERCA pump due to decreased Thr17-PLN phosphorylation suggest a downregulation of CaMKII in MetS...
Source: Frontiers in Physiology - April 29, 2019 Category: Physiology Source Type: research

Early Pulmonary Vascular Disease in Young Adults Born Preterm.
CONCLUSION: Young adults born preterm demonstrate early pulmonary vascular disease, characterized by elevated pulmonary pressures, a stiffer pulmonary vascular bed, and right ventricular dysfunction, consistent with an increased risk of developing pulmonary hypertension. PMID: 29944842 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - June 26, 2018 Category: Respiratory Medicine Authors: Goss KN, Beshish AG, Barton GP, Haraldsdottir K, Levin TS, Tetri LH, Battiola TJ, Mulchrone AM, Pegelow DF, Palta M, Lamers LJ, Watson AM, Chesler NC, Eldridge MW Tags: Am J Respir Crit Care Med Source Type: research

Decrease the Symptoms of Sleep Apnea
by Phil Hardesty New research is showing that exercise not only helps the quality of our sleep, but it can improve conditions such as obstructive sleep apnea, or OSA. What is OSA? Obstructive sleep apnea is a condition where a person's breathing frequently pauses during sleep. One of the most noticeable sign of OSA is snoring. Other signs and symptoms of OSA are: Excessive daytime fatigue and sleepiness Observed episodes of breathing cessation during sleep Abrupt awakenings accompanied by shortness of breath Awakening with a dry mouth or sore throat Awakening with chest pain Sudden waking with gasping for breath Mornin...
Source: Healthy Living - The Huffington Post - June 6, 2016 Category: Consumer Health News Source Type: news

Eating your 5 A DAY 'could make you more optimistic'
Conclusion This is well-conducted research which has used a validated measure to assess the optimism of a sample of middle-aged American citizens and measure their blood antioxidant levels. The researchers found a link between higher carotenoid levels and higher optimism, but as the researchers rightly conclude, their findings do not prove cause and effect and it isn’t possible to say in which direction the relationship is going. It is possible that having higher levels of antioxidants in the body leads to better physical health and this in turn enhances optimism, but then it is equally possible that people who are in be...
Source: NHS News Feed - January 18, 2013 Category: Consumer Health News Tags: Food/diet Mental health Source Type: news