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Impaired Activity of Ryanodine Receptors Contributes to Calcium Mishandling in Cardiomyocytes of Metabolic Syndrome Rats
Conclusion Principal findings of this work are that abnormal Ca2+ transient amplitude, contractile dysfunction; and impaired relaxation of MetS cardiomyocytes underlies intrinsic dysfunctional RyR2 and SERCA pump. Abnormal activity of RyRs was evidenced by its decreased ability to bind [3H]-ryanodine. Although the MetS condition does not modify RyR2 protein expression, its phosphorylation at Ser2814 is decreased, which impairs its capacity for activation during ECC. The dysfunctional RyRs, together with a decreased activity of SERCA pump due to decreased Thr17-PLN phosphorylation suggest a downregulation of CaMKII in MetS...
Source: Frontiers in Physiology - April 29, 2019 Category: Physiology Source Type: research

Spacing out after staying up late? Here ’s why
Ever sleep poorly and then walk out of the house without your keys? Or space out while driving to work and nearly hit a stalled car?A new study led by UCLA ’sDr. Itzhak Fried is the first to reveal how sleep deprivation disrupts brain cells ’ ability to communicate with each other. Fried and his colleagues believe that disruption leads to temporary mental lapses that affect memory and visual perception. Their findings are published online today by Nature Medicine.“We discovered that starving the body of sleep also robs neurons of the ability to function properly,” said Fried, the study’s senior author, a profess...
Source: UCLA Newsroom: Health Sciences - November 6, 2017 Category: Universities & Medical Training Source Type: news

Eating your 5 A DAY 'could make you more optimistic'
Conclusion This is well-conducted research which has used a validated measure to assess the optimism of a sample of middle-aged American citizens and measure their blood antioxidant levels. The researchers found a link between higher carotenoid levels and higher optimism, but as the researchers rightly conclude, their findings do not prove cause and effect and it isn’t possible to say in which direction the relationship is going. It is possible that having higher levels of antioxidants in the body leads to better physical health and this in turn enhances optimism, but then it is equally possible that people who are in be...
Source: NHS News Feed - January 18, 2013 Category: Consumer Health News Tags: Food/diet Mental health Source Type: news