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Melatonin ameliorates cerebral ischemia/reperfusion injury through SIRT3 activation
This study provides novel therapeutic targets and mechanisms for the treatment of ischemic stroke in the clinic, especially during cerebrovascular reperfusion.
Source: Life Sciences - November 6, 2019 Category: Biology Source Type: research

Ischemic brain injury: new insights on the protective role of melatonin.
Abstract Stroke represents one of the most common causes of brain's vulnerability for many millions of people worldwide. The plethora of physiopathological events associated with brain ischemia are regulate through multiple signaling pathways leading to the activation of oxidative stress process, Ca2+ dyshomeostasis, mitochondrial dysfunction, proinflammatory mediators, excitotoxicity and/or programmed neuronal cell death. Understanding this cascade of molecular events is mandatory in order to develop new therapeutic strategies for stroke. In this review article, we have highlighted the pleiotropic effects of mela...
Source: Free Radical Biology and Medicine - January 4, 2017 Category: Biology Authors: Ramos E, Patiño P, Reiter RJ, Gil-Martín E, Marco-Contelles J, Parada E, Los Rios C, Romero A, Egea J Tags: Free Radic Biol Med Source Type: research