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Melatonin Offers Dual-Phase Protection to Brain Vessel Endothelial Cells in Prolonged Cerebral Ischemia-Recanalization Through Ameliorating ER Stress and Resolving Refractory Stress Granule
We report that melatonin treatment downregulates ER stress in the ischemic period and enhances dissociation of the refractory SGs during reperfusion, thus offering dual-phase protection to BVECs in prolonged cerebral stroke. Mechanistically, melatonin enhances autophagy in BVECs, which preserves ER function and resolves refractory SGs. We, therefore, propose that melatonin is a potential treatment to extend the time window of delayed recanalization therapy in AIS.PMID:36181629 | DOI:10.1007/s12975-022-01084-7
Source: Cell Research - October 1, 2022 Category: Cytology Authors: Danli Lu Yuxin Liu Huipeng Huang Mengyan Hu Tiemei Li Shisi Wang Shishi Shen Ruizhen Wu Wei Cai Tingting Lu Zhengqi Lu Source Type: research

Agomelatine Exerts an Anti-inflammatory Effect by Inhibiting Microglial Activation Through TLR4/NLRP3 Pathway in pMCAO Rats
In this study, we aimed to investigate the anti-inflammatory effect of agomelatine in a permanent middle cerebral artery occlusion (pMCAO) model. Forty-eight male Wistar rats were randomly divided into four groups: sham, pMCAO + vehicle, pMCAO + agomelatine (40 mg/kg, i.p.), and pMCAO + melatonin (10 mg/kg, i.p.) groups. On day 1 after permanent cerebral ischemia, the animals were sacrificed, and brain tissues were collected for western blot analysis, and immunohistochemistry. Agomelatine treatment ameliorated inflammatory responses by decreasing the protein levels of trigger Toll-like receptor (TLR4)/nuclear factor kappa-...
Source: Cell Research - November 29, 2021 Category: Cytology Authors: Wijitra Chumboatong Satchakorn Khamchai Chainarong Tocharus Piyarat Govitrapong Jiraporn Tocharus Source Type: research

Ramelteon Mitigates Free Fatty Acid (FFA)-Induced Attachment of Monocytes to Brain Vascular Endothelial Cells
In conclusion, Ramelteon mitigated FFA-induced attachment of monocytes to brain vascular endothelial cells by increasing the expression of KLF2 and reducing the expression of E-selectin.PMID:34792763 | DOI:10.1007/s12640-021-00422-1
Source: Cell Research - November 18, 2021 Category: Cytology Authors: Guijie Wang Fang Tian Yu Li Yang Liu Chunfeng Liu Source Type: research