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The association between clopidogrel and 2-oxo-clopidogrel plasma levels and the long-term clinical outcome after acute myocardial infarction 
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CONCLUSION: In patients with acute MI treated with PCI, lower dose-adjusted clopidogrel and dose-adjusted 2-oxo-clopidogrel plasma concentrations were associated with an increased risk of ischemic events.
. PMID: 30431425 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Pharmacology and Therapeutics - November 17, 2018 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Preventable Cases of Oral Anticoagulant-Induced Bleeding: Data From the Spontaneous Reporting System
Conclusion: Our findings describe the most reported risk factors for preventability of oral anticoagulant-induced bleedings. These factors may be useful for targeting interventions to improve pharmacovigilance activities in our regional territory and to reduce the burden of medication errors and inappropriate prescription. Introduction Oral anticoagulant therapy is widely used for the prevention of stroke and systemic embolism in patients with atrial fibrillation, or for the prevention and treatment of deep vein thrombosis and pulmonary embolism (Raj et al., 1994; Monaco et al., 2017). Oral anticoagulants can be di...
Source: Frontiers in Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research

Negative hemodynamic effects of pantoprazole at high infusion rates in mice
ConclusionAt higher infusion rates pantoprazole is able to induce negative hemodynamic responses. Especially in the setting of heart failure these effects can lead to significant impairment of cardiac function. Therefore high infusion rates of pantoprazole should be avoided especially in heart failure patients.This article is protected by copyright. All rights reserved.
Source: Cardiovascular Therapeutics - December 1, 2014 Category: Cardiology Authors: Bernhard Unsöld, Nils Teucher, Michael Didié, Samuel Sossalla, Claudius Jacobshagen, Tim Seidler, Wolfgang Schillinger, Gerd Hasenfuß Tags: Original Research Article Source Type: research