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Nobiletin improves propofol-induced neuroprotection via regulating Akt/mTOR and TLR 4/NF- κB signaling in ischemic brain injury in rats.
CONCLUSION: Propofol post-conditioning either with nobiletin prior I/R injury was found to be more effective than propofol alone, suggesting the positive effects of nobiletin on propofol-mediated anti-inflammatory and neuroprotective effects. PMID: 28478273 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 4, 2017 Category: Drugs & Pharmacology Authors: Zheng Y, Bu J, Yu L, Chen J, Liu H Tags: Biomed Pharmacother Source Type: research

Nobiletin improves propofol-induced neuroprotection via regulating Akt/mTOR and TLR 4/NF- κB signaling in ischemic brain injury in rats
Conclusion Propofol post-conditioning either with nobiletin prior I/R injury was found to be more effective than propofol alone, suggesting the positive effects of nobiletin on propofol-mediated anti-inflammatory and neuroprotective effects.
Source: Biomedicine and Pharmacotherapy - May 4, 2017 Category: Drugs & Pharmacology Source Type: research

Hemodynamic responses during induction: comparison of Marsh and Schnider pharmacokinetic models.
CONCLUSIONS: When target concentrations are titrated according to NI during induction of anesthesia, Marsh's model could induce sedation faster than Schnider's. Meanwhile, hemodynamic changes were not observed to be statistically different between the two models. Hypotension induced by plasma target-controlled infusion of propofol could mainly be attributed to decreased stroke volume instead of vascular dilation. PMID: 25500489 [PubMed - in process]
Source: International Journal of Clinical Pharmacology and Therapeutics - June 4, 2015 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research