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The pivotal role of micro-environmental cells in a human blood –brain barrier in vitro model of cerebral ischemia: functional and transcriptomic analysis
ConclusionsThe co-cultivation with micro-environmental cells is necessary to achieve a functional breakdown of the BBB in the cerebral ischemia model within an in vivo relevant time window. Comprehensive studies by qPCR revealed that distinct expression clusters of barrier markers exist and that these are regulated by different treatments (even by growth medium change) indicating that controls for single cell culture manipulation steps are crucial to understand the observed effects properly.
Source: Fluids and Barriers of the CNS - March 4, 2020 Category: Neuroscience Source Type: research

Ischemia/reperfusion-induced upregulation of TIGAR in brain is mediated by SP1 and modulated by ROS and hormones involved in glucose metabolism
Publication date: Available online 4 November 2014 Source:Neurochemistry International Author(s): Meiling Sun , Mei Li , Qiao Huang , Feng Han , Jin-hua Gu , Jiaming Xie , Rong Han , Zheng-Hong Qin , Zhipeng Zhou We previously found that TIGAR (TP53-induced glycolysis and apoptosis regulator) was upregulated in response to ischemia/reperfusion insult in a TP53-independent manner. The present study sought to investigate the regulatory mechanisms of TIGAR upregulation in animal and cellular models of stroke. The animal and cellular models of ischemia/reperfusion were produced by transient middle cerebral artery occlusion a...
Source: Neurochemistry International - November 4, 2014 Category: Neuroscience Source Type: research