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Total 22 results found since Jan 2013.
A case of Lemierre's syndrome causing panhypopituitarism, cavernous sinus thrombosis, ischaemic stroke and pulmonary embolism
We present the case of a previously well 19-year-old man, who presented acutely unwell with meningitis and sepsis. Fusobacterium necrophorum was isolated from peripheral blood cultures and identified on cerebrospinal fluid with 16S rDNA Polymerase Chain Reaction (PCR). Imaging demonstrated internal jugular vein thrombosis with subsequent cavernous venous sinus thrombosis. Pituitary function tests were suggestive of panhypopituitarism. The patient was diagnosed with Lemierre's syndrome complicated by meningitis, cavernous sinus thrombosis, base of skull osteomyelitis, ischaemic stroke and panhypopituitarism. He was treated ...
Source: Journal of the Royal College of Physicians of Edinburgh - September 7, 2023 Category: General Medicine Authors: Charlotte J Dewdney Joseph J Anderson Simon Dewar Fergus Doubal Frederick R Burgess Deepak Subedi Marcus J Lyall Source Type: research
Epidemiology and Comorbidity of Adrenal Cushing Syndrome: A Nationwide Cohort Study
CONCLUSIONS: Adrenal CS is associated with multiple comorbidities even after treatment, which necessitates meticulous postoperative care.PMID:34932806 | DOI:10.1210/clinem/dgaa752
Source: The Journal of Clinical Endocrinology and Metabolism - December 21, 2021 Category: Endocrinology Authors: Chang Ho Ahn Jung Hee Kim Man Young Park Sang Wan Kim Source Type: research
The pivotal role of micro-environmental cells in a human blood –brain barrier in vitro model of cerebral ischemia: functional and transcriptomic analysis
ConclusionsThe co-cultivation with micro-environmental cells is necessary to achieve a functional breakdown of the BBB in the cerebral ischemia model within an in vivo relevant time window. Comprehensive studies by qPCR revealed that distinct expression clusters of barrier markers exist and that these are regulated by different treatments (even by growth medium change) indicating that controls for single cell culture manipulation steps are crucial to understand the observed effects properly.
Source: Fluids and Barriers of the CNS - March 4, 2020 Category: Neuroscience Source Type: research
Combined use of high doses of vasopressin and corticosteroids in a patient with Crohn ’s disease with refractory septic shock after intestinal perforation: a case report
ConclusionsThe significant increase in her cardiac index and stroke volume index resulted in an improvement in peripheral resistance, gas exchange, and urine output and a decrease in her heart rate, interleukin-6 level, and tumor necrosis factor- α level. The administration of high doses of vasopressin and corticosteroids was demonstrated to be safe for the immune system, to reduce the systemic inflammatory response, and to have direct cardiovascular effects. Further studies are required to examine the use of vasopressin as an initial vasop ressor as well as its use in high dosages and in combination with corticosteroids.
Source: Journal of Medical Case Reports - November 13, 2017 Category: General Medicine Source Type: research
