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Effect of folic acid supplementation on the change of plasma < em > S < /em > -adenosylhomocysteine level in Chinese hypertensive patients: a randomized, double-blind, controlled clinical trial
In conclusion, supplementation of 2.4 mg/day folic acid can lead to increased SAH levels, especially in MTHFR C677T genotype CT and TT.PMID:36447492 | PMC:PMC9701592 | DOI:10.3164/jcbn.22-13
Source: Clinical Biochemistry - November 30, 2022 Category: Biochemistry Authors: Ru-Shan Zhang Lei Tang Yan Zhang Xiu-Li Shi Ji Shu Li Wang Xu Zhang Ya-Ping Xu Jian-Fei Zou Rui Wang Hao Chen Gen-Fu Tang Source Type: research

Combinational effect of angiotensin receptor blocker and folic acid therapy on uric acid and creatinine level in hyperhomocysteinemia associated hypertension
This article is protected by copyright. All rights reserved
Source: Biotechnology and Applied Biochemistry - July 16, 2019 Category: Biochemistry Authors: Yogendra Singh, Vijaya Paul Samuel, Sunita Dahiya, Gaurav Gupta, Ritu Gillhotra, Anurag Mishra, Mahaveer Singh, Nagaraja SreeHarsha, Shiva Kumar Gubbiyappa, Murtaza M. Tambuwala, Dinesh Kumar Chellappan, Kamal Dua Tags: Review Article Source Type: research

Folic acid deficiency increases brain cell injury via autophagy enhancement after focal cerebral ischemia
Folic acid (FA) deficiency is not only associated with an increased risk of ischemic stroke, but also with increased oxidative DNA damage and brain injury after cerebral ischemia –reperfusion. However, the cellular and molecular mechanisms underlying FA deficiency-associated neuropathogenesis are not completely understood. In the present study, we tested the hypothesis that neuronal autophagy in focal cerebral ischemia rats may be involved in the mechanisms of FA deficienc y -induced injury to neuronal cells.
Source: The Journal of Nutritional Biochemistry - September 6, 2016 Category: Biochemistry Authors: Yaqian Zhao, Guowei Huang, Shuang Chen, Yun Gou, Zhiping Dong, Xumei Zhang Source Type: research