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H‐Type hypertension, stroke and diabetes in China: Opportunities for primary prevention / H型高血压,脑卒中和糖尿病:中国人群一级预防的机遇
1969年,McCully 首次发现同型半胱氨酸水平即使轻度升高也可加速动脉粥样硬化的发展,由此提出“同型半胱氨酸‐动脉粥样硬化学说”1。接下来的一些前瞻性队列研究提出,同型半胱氨酸水平每降低3 µmol/L可以使脑卒中风险下降24%2。然而,考察降低同型半胱氨酸治疗对脑卒中影响的一些随机、对照临床研究并未观察到明确的结果3。需要注意的是,流行病学研究与临床试验存在诸多重要的不同之处。一般队列研究多关注相对健康人群,而大多数临床研究入组的则是患有心脑血管疾病...
Source: Journal of Diabetes - November 4, 2015 Category: Endocrinology Authors: Xianhui Qin, Yong Huo Tags: Commentary ‐ by Invitation Only Source Type: research

Effect of folic acid supplementation on risk of new‐onset diabetes in adults with hypertension in China: Findings from the CSPPT
ConclusionsAmong adults with hypertension with no history of stroke and/or MI in China, folic acid supplementation had no significant effect on the risk of new‐onset diabetes. This article is protected by copyright. All rights reserved.
Source: Journal of Diabetes - October 11, 2015 Category: Endocrinology Authors: Xianhui Qin, Jianping Li, Yan Zhang, Dafang Chen, Binyan Wang, Mingli He, Jia Fu, Genfu Tang, Yefeng Cai, Xiuli Shi, Xin Xu, Fan Fan Hou, Xiaobin Wang, Yong Huo Tags: Original Article Source Type: research

H‐type hypertension, stroke and diabetes in China: Opportunities for primary prevention
Abstract In summary, the CSPPT, with its large sample size and unique study design has provided a definitive answer regarding the role of folic acid supplementation in conjunction with anti‐hypertension therapy in the primary prevention of stroke. Further studies are needed to examine the joint effect of anti‐hypertensive treatment and folic acid supplementation on the development or progression of T2DM as well as vascular complications, particularly in populations without folic acid fortification. If these relationships can be established and underlying mechanisms elucidated, the implications for clinical and public h...
Source: Journal of Diabetes - September 1, 2015 Category: Endocrinology Authors: Xianhui Qin, Yong Huo Tags: Original Article Source Type: research