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Tramadol ‐induced intracerebral hemorrhage: A rare case report
AbstractA previously healthy middle-aged man with no vascular risk factors developed a hemorrhagic stroke. He had been using tramadol due to erectile dysfunction for 2  years. So, the patient developed right basal ganglia due to tramadol addiction.
Source: Clinical Case Reports - April 13, 2023 Category: General Medicine Authors: Nor Osman Sidow, Mohamed Farah Osman, Mohamed Sheikh Hassan, Abdulkadir Ahmed, Abdiwahid Ahmed Ibrahim Tags: CASE REPORT Source Type: research

GPs' management of polypharmacy and therapeutic dilemma in patients with multimorbidity: a cross-sectional survey of GPs in France.
CONCLUSION: In therapeutic dilemmas, some GPs choose to prioritise patients' requests over iatrogenic risks. GPs need pragmatic implementation tools for handling therapeutic dilemmas, and to improve their skills in medication management and patient engagement in such situations. PMID: 30803978 [PubMed - as supplied by publisher]
Source: The British Journal of General Practice - February 25, 2019 Category: Primary Care Authors: Carrier H, Zaytseva A, Bocquier A, Villani P, Verdoux H, Fortin M, Verger P Tags: Br J Gen Pract Source Type: research

Cerebral ischaemia/reperfusion injury could be managed by using tramadol.
DISCUSSION: Tramadol can ameliorate the histopathological structure of ischaemic tissue in both periods of I/R injury in rat. We suggest further research investigating various dosages with different administration methods of tramadol in stroke should be conducted by adopting different explorative techniques. PMID: 29792388 [PubMed - as supplied by publisher]
Source: Neurological Research - May 26, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Hemopericardium under dabigatran for stroke prevention in atrial fibrillation
We report a polymorbid 75-year old male under a therapy with dabigatran, valsartan, amlodipine, nicorandil, furosemide, atorvastatin, bisoprolol, metformin, tizanidine, pantoprazole, and tramadol. He suffered from chest pain for 4 months. Coronary angiography showed only ectatic coronary arteries. He started taking nonsteroidal anti-inflammatory drugs. He was hospitalized because of dyspnea starting 10 days before admission, melena, and renal failure. Hemopericardium was diagnosed and pericardiocentesis yielded 2000 ml hemorrhagic fluid. Review of previous echocardiograms showed a 4 mm echo-free space, epicardial fat o...
Source: Blood Coagulation and Fibrinolysis - February 11, 2017 Category: Hematology Tags: Case Reports Source Type: research

Modulatory effect of cilostazol on tramadol-induced behavioral and neurochemical alterations in rats challenged across the forced swim despair test
Publication date: Available online 30 May 2016 Source:Beni-Suef University Journal of Basic and Applied Sciences Author(s): Noha M. Gamil, Yousreya A. Maklad, Maha A.E. Ahmed, Shahira Nofal, Amany A.E. Ahmed Pain-associated depression is encountered clinically in some cases such as cancer, chronic neuropathy, and after operations. Tramadol is an opioid analgesic drug that may modulate monoaminergic neurotransmission by inhibition of noradrenaline and serotonin reuptake that may contribute to its antidepressant-like effects. Clinically, tramadol is used either alone or in combination with other NSAIDs in the treatmen...
Source: Beni Suef University Journal of Basic and Applied Sciences - May 30, 2016 Category: Science Source Type: research

Nursing Home Residents with Seizure Disorders/Epilepsy: Prevalence, Characteristics, and Treatment Patterns (P1.080)
Conclusions: NHRs with seizure disorder/epilepsy have substantial physical and cognitive impairment. Nearly half were prescribed combination AED therapy, and >20[percnt] took 蠅3 different AEDs, suggesting refractory epilepsy. Additional research is needed to assess treatment outcomes and further define optimal care in this population.Disclosure: Dr. Zarowitz has nothing to disclose. Dr. Allen has nothing to disclose. Dr. OShea has nothing to disclose. Dr. Wang has nothing to disclose. Dr. Semenchuk has nothing to disclose. Dr. Barghout has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Zarowitz, B., Allen, C., OShea, T., Wang, Z., Semenchuk, M., Barghout, V. Tags: Epilepsy/Clinical Neurophysiology: Geriatric Epilepsy, Epidemiology, and Health Services Source Type: research

Table of Contents
Abstract Study of antidepressants finds modest effect on QT prolongation Reckitt blocked by FDA on buprenorphine, faces FTC inquiry SSRIs and tramadol: Possible link to serotonin syndrome Orexin receptor antagonist effective for insomnia Antipsychotics' receptor profiles linked to stroke risk FDA offers new guidance on developing drugs for Alzheimer's disease Common genetic variation and antidepressant efficacy Antipsychotics and weight change Pharmacogenetic study looks at cocaine abuse Polymorphism predicts escitalopram dose for depression D‐cycloserine impact on fear examined SSRI drugs and ischemic heart disease and ...
Source: The Brown University Psychopharmacology Update - April 9, 2013 Category: Psychiatry Source Type: research