• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Characterization of Astrocytes in the Minocycline-Administered Mouse Photothrombotic Ischemic Stroke Model
In this study, we used a mouse photothrombotic ischemic stroke model to examine the characteristics of astrocytes after the administration of minocycline during ischemic stroke. Minocycline increased astrocyte reactivity and affected the localization of astrocytes in the penumbra region. Molecular characterization revealed that the induced expression of mRNA encoding the fatty acid binding protein 7 (FABP7) by photothrombosis was enhanced by the minocycline administration. Meanwhile, minocycline did not significantly affect the phenotype or class of astrocytes. The expression of Fabp7 mRNA was well correlated with that of ...
Source: Neurochemical Research - July 30, 2022 Category: Neuroscience Authors: Mari Kondo Haruka Okazaki Kei Nakayama Hirofumi Hohjoh Kimie Nakagawa Eri Segi-Nishida Hiroshi Hasegawa Source Type: research

Neuroprotection by insulin-like growth factor-1 in rats with ischemic stroke is associated with microglial changes and a reduction in neuroinflammation
Publication date: Available online 14 December 2019Source: NeuroscienceAuthor(s): Ahmad Serhan, Joeri L. Aerts, EWGM Boddeke, Ron KooijmanAbstractWe and others have shown that insulin-like growth factor-1 (IGF-1) is neuroprotective when administered systemically shortly following stroke. In the current study, we addressed the hypothesis that microglia mediate neuroprotection by IGF-1 following ischemic stroke. Furthermore, we investigated whether IGF-1 modulates pro- and anti-inflammatory mediators in ischemic brain with a special reference to microglia. Ischemic stroke was induced in normal conscious Wistar rats by infusi...
Source: Neuroscience - December 16, 2019 Category: Neuroscience Source Type: research

Neuroprotective effects of minocycline and progesterone on white matter injury after focal cerebral ischemia
Publication date: Available online 22 April 2019Source: Journal of Clinical NeuroscienceAuthor(s): Heba Faheem, Ahmed Mansour, Alaa Elkordy, Sherif Rashad, Mohamed Shebl, Mohamed Madi, Salma Elwy, Kuniyasu Niizuma, Teiji TominagaAbstractStroke induced white matter injury can induce marked neurological deficits even after relatively small infarcts, due to the tightly packed nature of white matter tracts especially in certain areas in the brain. Many drugs which were successful in the pre-clinical trials failed in clinical trials, which was attributed in part to the focus on grey matter injury completely and ignoring their e...
Source: Journal of Clinical Neuroscience - April 24, 2019 Category: Neuroscience Source Type: research

Sex differences in stroke therapies
Stroke is the fifth leading cause of death and acquired disability in aged populations. Women are disproportionally affected by stroke, having a higher incidence and worse outcomes than men. Numerous preclinical studies have discovered novel therapies for the treatment of stroke, but almost all of these have been shown to be unsuccessful in clinical trials. Despite known sex differences in occurrence and severity of stroke, few preclinical or clinical therapeutics take into account possible sex differences in treatment. Reanalysis of data from studies of tissue plasminogen activator (tPA), the only currently FDA‐approved...
Source: Journal of Neuroscience Research - November 6, 2016 Category: Neuroscience Authors: Farida Sohrabji, Min Jung Park, Amanda H. Mahnke Tags: Review Source Type: research

Minocycline mitigates the gliogenic effects of proinflammatory cytokines on neural stem cells
Mobilizing endogenous neural stem cells (NSCs) in the adult brain is designed to enhance the brain's regenerative capacity after cerebral lesions, e.g., as a result of stroke. Cerebral ischemia elicits neuroinflammatory processes affecting NSCs in multiple ways, the precise mechanisms of which currently remain elusive. An inhibitory effect of minocycline on microglia activation, a hallmark of postischemic neuroinflammation, has already been demonstrated in clinical trials, showing minocycline to be safe and potentially effective in ischemic stroke. Here we investigate the direct effects of minocycline and of proinflammator...
Source: Journal of Neuroscience Research - November 3, 2015 Category: Neuroscience Authors: Sabine Ulrike Vay, Stefan Blaschke, Rebecca Klein, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger Tags: Research Article Source Type: research

Minocycline ameliorates hypoxia-induced blood–brain barrier damage by inhibition of HIF-1α through SIRT-3/PHD-2 degradation pathway
Conclusions: Minocycline inhibits HIF-1α-mediated cellular responses and protects BBB integrity through SIRT-3/PHD-2 pathway, proving to be a potential drug for the prevention and treatment of hypoxic brain injuries.
Source: Neuroscience - August 7, 2015 Category: Neuroscience Source Type: research

Minocycline-induced polyarteritis nodosa-like vasculitis presenting as brainstem stroke
This report shows that ischemic strokes may occur as a result of minocycline-induced vasculitis. While this is likely a rare association, recognition is important given the widespread use of minocycline and the potential for devastating consequences in a young population. Consequently, drug-induced vasculitis should be considered in patients with an ischemic stroke taking minocycline.
Source: Journal of Clinical Neuroscience - April 28, 2015 Category: Neuroscience Source Type: research

Involvement of matrix metalloproteinases‐2 and ‐9 in the formation of a lacuna‐like cerebral cavity
We used a modified pial vessel disruption (PVD) protocol with adult male Wistar rats to mimic small‐vessel stroke in the cerebral cortex. Within 3 weeks, this lesion develops into a single lacuna‐like cavity, which is fluid‐filled and encapsulated by reactive astrocytes. Minocycline treatment that commences 1 hr after lesion and continues for 6 days prevents the cavitation and causes a filling of the lesion with reactive astrocytes and no barrier. Here, we determined whether inhibition of matrix metalloproteinases‐2 and ‐9 (MMPs) mediates this minocycline action. Confocal microscopy revealed increased punctate st...
Source: Journal of Neuroscience Research - April 22, 2013 Category: Neuroscience Authors: Francisco S. Cayabyab, Krishnamoorty Gowribai, Wolfgang Walz Tags: Research Article Source Type: research