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Potential Applications of Remote Limb Ischemic Conditioning for Chronic Cerebral Circulation Insufficiency
Conclusion Due to its long-term and often invisible course, CCCI has received less attention than acute cerebral ischemic stroke. However, without appropriate intervention, CCCI may lead to a variety of adverse events. Because the pathophysiological changes associated with CCCI are complex, pharmacological research in this area has been disappointing. Recent research suggests that RLIC, which is less invasive and more well-tolerated than drug treatment, can activate endogenous protective mechanisms during CCCI. In the present report, we reviewed studies related to CCCI (Table 1), as well as those related to stroke and sta...
Source: Frontiers in Neurology - May 2, 2019 Category: Neurology Source Type: research

Minocycline for acute stroke treatment: a systematic review and meta-analysis of randomized clinical trials
ConclusionsAlthough data is limited, minocycline demonstrated efficacy and seems a promising neuroprotective agent in acute stroke patients, especially  in AIS subgroup. Further RCTs are needed to evaluate the efficacy and safety of minocycline among ICH patients.
Source: Journal of Neurology - June 14, 2018 Category: Neurology Source Type: research

Activation of microglia within paraventricular nucleus of hypothalamus is NOT involved in maintenance of established hypertension.
CONCLUSIONS: Activated microglia with morphological alteration within PVN are not involved in the maintenance of established severe hypertension, and inflammation within PVN could not be the therapeutic target of established hypertension. PMID: 26874752 [PubMed - as supplied by publisher]
Source: Journal of Cardiology - February 10, 2016 Category: Cardiology Authors: Takesue K, Kishi T, Hirooka Y, Sunagawa K Tags: J Cardiol Source Type: research

An open‐label evaluator‐blinded clinical study of minocycline neuroprotection in ischemic stroke: gender‐dependent effect
ConclusionPatients with ischemic stroke who received oral minocycline daily for 5 days had significantly better neurological outcomes on day 90 than controls. However, females showed no significant clinical improvement compared to males.
Source: Acta Neurologica Scandinavica - August 23, 2014 Category: Neurology Authors: M. R. Amiri‐Nikpour, S. Nazarbaghi, M. Hamdi‐Holasou, Y. Rezaei Tags: Original Article Source Type: research