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Total 84 results found since Jan 2013.
Sitagliptin therapy improves myocardial perfusion and arteriolar collateralization in chronically ischemic myocardium: A pilot study
In conclusion, in chronically ischemic myocardium, sitagliptin improves myocardial perfusion and arteriolar collateralization via the activation of pro-arteriogenic signaling pathways.
Source: Physiological Reports - June 11, 2023 Category: Physiology Authors: Sharif A. Sabe,
Dwight Douglas Harris,
Mark Broadwin,
Mohamed Sabra,
Cynthia M. Xu,
Debolina Banerjee,
M. Ruhul Abid,
Frank W. Sellke Tags: ORIGINAL ARTICLE Source Type: research
Evaluation of anti-atherosclerotic effects of Sitagliptin via modulation of the mTOR pathway in male rabbits
This study aimed to investigate the effect of Sitagliptin on the progression of atherosclerosis. Twenty-one male New Zealand White rabbits weighing 2-2.5 kg each were split into three groups: normal control, atherogenic control, and Sitagliptin-treated. The following parameters: serum triglycerides (TG), total cholesterol (TC), LDL, and a tissue autophagy marker (p62) using ELISA, aortic mRNA expression of mTORC1 marker using Real-Time Quantitative PCR(RT-qPCR), and histological inspection of the aorta were assessed. The mRNA expression of mTORC1 and the lipid profile of aortic tissue are considerably elevated in atherogen...
Source: Journal of Medicine and Life - May 11, 2023 Category: General Medicine Authors: Hussam Hamza Sahib Bassim Mohammad Najah Rayish Hadi Source Type: research
