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Total 1186 results found since Jan 2013.
Myocardial Infarction Following Intravenous Thrombolysis for Acute Ischemic Stroke: Case Report and Literature Review
We describe a case of early anterior myocardial infarction during intravenous thrombolysis for stroke and review the current literature.
Source: Journal of Stroke and Cerebrovascular Diseases - April 20, 2017 Category: Neurology Authors: Marina Mannino, Salvatore Asciutto, Valeria Terruso, Matilde Gammino, Melchiorre Gilberto Cellura, Serena Monaco Tags: Case Studies Source Type: research
Use of Noncontrast Computed Tomography and Computed Tomographic Perfusion in Predicting Intracerebral Hemorrhage After Intravenous Alteplase Therapy Clinical Sciences
Background and Purpose—Intracerebral hemorrhage is a feared complication of intravenous alteplase therapy in patients with acute ischemic stroke. We explore the use of multimodal computed tomography in predicting this complication.Methods—All patients were administered intravenous alteplase with/without intra-arterial therapy. An age- and sex-matched case–control design with classic and conditional logistic regression techniques was chosen for analyses. Outcome was parenchymal hemorrhage on 24- to 48-hour imaging. Exposure variables were imaging (noncontrast computed tomography hypoattenuation degree, relative volume...
Source: Stroke - May 22, 2017 Category: Neurology Authors: Connor Batchelor, Pooneh Pordeli, Christopher D. d’Esterre, Mohamed Naȷm, Fahad S. Al–Aȷlan, Mari E. Boesen, Connor McDougall, Lisa Hur, Enrico Fainardi, Jai Jai Shiva Shankar, Marta Rubiera, Alexander V. Khaw, Michael D. Hill, Tags: Blood-Brain Barrier, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research
Incidental Thrombotic Thrombocytopenic Purpura during Acute Ischemic Stroke and Thrombolytic Treatment
In this study, a patient with AIS and thrombotic thrombocytopenic purpura (TTP) symptoms during thrombolytic treatment was presented.
Source: Journal of Stroke and Cerebrovascular Diseases - November 28, 2017 Category: Neurology Authors: İbrahim Acır, Hacı Ali Erdoğan, Vildan Yayla, Nilay Taşdemir, Murat Çabalar Tags: Case Report Source Type: research
Response by Oppenheim et al to Letter Regarding Article, “Outcome After Reperfusion Therapies in Patients With Large Baseline Diffusion-Weighted Imaging Stroke Lesions: A THRACE Trial (Mechanical Thrombectomy After Intravenous Alteplase Versus Alteplase Alone After Stroke) Subgroup Analysis” Letter to the Editor
Source: Stroke - May 25, 2018 Category: Neurology Authors: Catherine Oppenheim, Serge Bracard, Francis Guillemin Tags: Magnetic Resonance Imaging (MRI), Prognosis, Treatment, Ischemic Stroke Letters to the Editor Source Type: research
Stroke Thrombolysis in Patients Taking Ticagrelor –Two Successful Cases and a Review of the Literature
Ticagrelor is a novel antiplatelet agent that is frequently used for secondary prevention in coronary artery disease and has emerging evidence in stroke after the recent results of SOCRATES and THALES trials. The use of intravenous thrombolysis with alteplase in acute ischemic stroke (AIS) patients on ticagrelor is a topic of debate as the safety profile of ticagrelor in this setting is not well established.
Source: Journal of Stroke and Cerebrovascular Diseases - December 11, 2020 Category: Neurology Authors: David R. Landzberg, Stephen English, Michael Frankel, Digvijaya Navalkele Source Type: research
Histological composition of retrieved emboli in acute ischemic stroke is independent of pre-thrombectomy alteplase use
Given recent evidence suggesting the clot composition may be associated with revascularization outcomes and stroke etiology, clot composition research has been a topic of growing interest. It is currently unclear what effect, if any, pre-thrombectomy thrombolysis has on clot composition. Understanding this association is important as it is a potential confounding variable in clot composition research. We retrospectively evaluated the composition of retrieved clots from ischemic stroke patients who did and did not receive pre-treatment tPA to study the effect of tPA on clot composition.
Source: Journal of Stroke and Cerebrovascular Diseases - February 17, 2022 Category: Neurology Authors: Waleed Brinjikji, Mehdi Abbasi, Oana Madalina Mereuta, Se án Fitzgerald, Jorge Arturo Larco, Daying Dai, Ramanathan Kadirvel, Raul G. Nogueira, Peter Kvamme, Kennith F. Layton, Josser E. Delgado, Ricardo A. Hanel, Vitor M. Pereira, Mohammed A. Almekhlafi Source Type: research
Outcomes with IV tenecteplase and IV alteplase for acute ischemic stroke with or without thrombectomy in real-world settings in the United States
Although many stroke centers in United States are using intravenous (IV) tenecteplase (TNK) for acute ischemic stroke patients, there is paucity of comparative data between IV TNK and IV alteplase from real-world settings.
Source: Journal of Stroke and Cerebrovascular Diseases - December 6, 2022 Category: Neurology Authors: Adnan I. Qureshi, William I. Baskett, Navpreet K. Bains, Brandi R. French, Farhan Siddiq, Camilo R. Gomez, Chi-Ren Shyu Source Type: research
Gender gap in stroke treatment likely due to delay by women seeking care
Women with clot-caused strokes are less likely than men to arrive at the hospital in time to receive the best treatment, according to a European study reported in the American Heart Association journal Stroke. In the study, 11 percent of women with acute ischemic strokes were treated with the clot-dissolving medication alteplase, compared with 14 percent of men. Study participants included 5,515 patients at 12 hospitals in the Netherlands...
Source: Health News from Medical News Today - July 29, 2013 Category: Consumer Health News Tags: Stroke Source Type: news
Fatal Intracranial Hemorrhage after Intravenous Thrombolytic Therapy for Acute Ischemic Stroke Associated with Cancer-related Nonbacterial Thrombotic Endocarditis
Nonbacterial thrombotic endocarditis (NBTE) is associated with hypercoagulability in patients with inflammatory states such as cancer and autoimmune diseases. Cardiac vegetations caused by NBTE often lead to life-threatening systemic thromboembolism that most frequently affects the brain, spleen, and kidneys. A 54-year-old woman diagnosed with ovarian cancer suddenly developed back pain and left hemiparesis. Although intravenous alteplase (rt-PA) therapy was administered to treat hyperacute ischemic infarction detected by magnetic resonance imaging, intracranial hemorrhage occurred in the left hemisphere several hours late...
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2014 Category: Neurology Authors: Takuya Yagi, Kie Takahashi, Mariko Tanikawa, Morinobu Seki, Takato Abe, Norihiro Suzuki Tags: Case Reports Source Type: research
Orolingual Angiodema Associated with Alteplase Treatment of Acute Stroke: A Reappraisal
Orolingual angioedema has been increasingly recognized as a potentially life-threatening complication associated with alteplase treatment of stroke. Concomitant treatment with an angiotension converting enzyme inhibitor (ACEi) and localization of infarction in the territory of middle cerebral artery seem to be associated with a higher risk of this complication.
Source: Journal of Stroke and Cerebrovascular Diseases - November 13, 2014 Category: Neurology Authors: Ana Sofia Correia, Gonçalo Matias, Sofia Calado, Ana Lourenço, Miguel Viana-Baptista Source Type: research
Correspondence Thrombolysis in acute stroke – Authors' reply
We thank the correspondents for their interest in our meta-analysis of individual patient data from trials of alteplase for patients with acute ischaemic stroke.1
Source: LANCET - April 10, 2015 Category: Journals (General) Authors: Jonathan Emberson, Kennedy R Lees, Patrick Lyden, Colin Baigent, Peter Sandercock, Werner Hacke, on behalf of the Stroke Treatment Trialists' Collaboration Tags: Correspondence Source Type: research
Twenty-Year History of the Evolution of Stroke Thrombolysis With Intravenous Alteplase to Reduce Long-Term Disability Topical Reviews
Source: Stroke - July 27, 2015 Category: Neurology Authors: Campbell, B. C. V., Meretoja, A., Donnan, G. A., Davis, S. M. Tags: Acute Cerebral Infarction, Emergency treatment of Stroke, Thrombolysis Topical Reviews Source Type: research
ENCHANTED results challenge reduced alteplase dose in Asian stroke patients
A reduced dose of alteplase has failed to prove itself noninferior to the standard dose in a predominantly Asian population of patients with ischaemic stroke.
Source: MedWire News - May 10, 2016 Category: Consumer Health News Tags: Stroke Source Type: news
Systemic Thrombolysis for Ischemic Stroke after Antagonizing Dabigatran with Idarucizumab—A Case Report
We here describe our experience of systemic thrombolysis therapy for severe ischemic stroke in a patient taking dabigatran for atrial fibrillation. After administration of the monoclonal antibody fragment idarucizumab, the anticoagulative effects of dabigatran were efficiently antagonized and application of alteplase was safe and feasible in our patient. This case report may illustrate a novel treatment option in the neurological emergency setting.
Source: Journal of Stroke and Cerebrovascular Diseases - May 24, 2016 Category: Neurology Authors: Niklas Schäfer, Andreas Müller, Ullrich Wüllner Tags: Case Studies Source Type: research
