Histological composition of retrieved emboli in acute ischemic stroke is independent of pre-thrombectomy alteplase use

Given recent evidence suggesting the clot composition may be associated with revascularization outcomes and stroke etiology, clot composition research has been a topic of growing interest. It is currently unclear what effect, if any, pre-thrombectomy thrombolysis has on clot composition. Understanding this association is important as it is a potential confounding variable in clot composition research. We retrospectively evaluated the composition of retrieved clots from ischemic stroke patients who did and did not receive pre-treatment tPA to study the effect of tPA on clot composition.

Source: Journal of Stroke and Cerebrovascular Diseases - February 17, 2022 Category: Neurology Authors: Waleed Brinjikji, Mehdi Abbasi, Oana Madalina Mereuta, Se án Fitzgerald, Jorge Arturo Larco, Daying Dai, Ramanathan Kadirvel, Raul G. Nogueira, Peter Kvamme, Kennith F. Layton, Josser E. Delgado, Ricardo A. Hanel, Vitor M. Pereira, Mohammed A. Almekhlafi Source Type: research