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Fine particulate matter exposure aggravates ischemic injury via NLRP3 inflammasome activation and pyroptosis
CONCLUSION: These results suggested that PM2.5 exposure triggered the activation of NLRP3 inflammasome and pyroptosis under ischemic conditions, which may be mediated by increased ROS production after ischemic stroke. These findings may provide a more enhanced understanding of the interplay between PM2.5 and neuroinflammation and cell death, and reveal a novel mechanism of PM2.5-mediated toxic effects after ischemic stroke.PMID:35403328 | DOI:10.1111/cns.13837
Source: CNS Neuroscience and Therapeutics - April 11, 2022 Category: Neuroscience Authors: Li Gao Jie-Xing Qin Jian-Quan Shi Teng Jiang Fei Wang Chong Xie Qing Gao Nan Zhi Qing Dong Yang-Tai Guan Source Type: research

Sirt1-ROS-TRAF6 Signaling-Induced Pyroptosis Contributes to Early Injury in Ischemic Mice
In this study, we evaluated the inflammatory reactions induced by acute ischemia and found that pyroptosis occurred after acute ischemia bothin vivo andin vitro, as determined by interleukin-1 β, apoptosis-associated speck-like protein, and caspase-1. The early inflammation resulted in irreversible ischemic injury, indicating that it deserves thorough investigation. Meanwhile, acute ischemia decreased the Sirtuin 1 (Sirt1) protein levels, and increased the TRAF6 (TNF receptor associated factor 6) protein and reactive oxygen species (ROS) levels. In further exploration, both Sirt1 suppression and TRAF6 activation were foun...
Source: Neuroscience Bulletin - April 5, 2020 Category: Neuroscience Source Type: research