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Duration of symptomatic stroke and successful reperfusion with endovascular thrombectomy for anterior circulation large vessel occlusive stroke
Conclusion In a real-world cohort of acute ischemic stroke patients with anterior circulation occlusion treated with endovascular therapy, longer duration of symptomatic stroke is associated with lower rates of successful reperfusion and reperfusion on the first pass.
Source: Journal of NeuroInterventional Surgery - November 18, 2021 Category: Neurosurgery Authors: de Havenon, A., Alexander, M. D., Nogueira, R. G., Haussen, D. C., Castonguay, A. C., Linfante, I., Johnson, M. A., Nguyen, T. N., Mokin, M., Zaidat, O. O. Tags: Ischemic stroke Source Type: research

Travel time and distance for bypass and non-bypass routing of stroke patients in the USA
Conclusions Bypass routing offers modest travel time benefits for LVO patients and incurs modest penalties for non-LVO patients. Differences are greatest in rural areas. A majority of Americans live in areas for which current guidelines recommend bypass.
Source: Journal of NeuroInterventional Surgery - June 16, 2023 Category: Neurosurgery Authors: Yu, C. Y., Panagos, P. D., Kansagra, A. P. Tags: Ischemic stroke Source Type: research

Rates of adverse events in patients with ischemic stroke treated at thrombectomy capable hospitals
Conclusions A decrease in-hospital adverse events and improved discharge outcomes were observed among patients with ischemic stroke admitted to a TCH compared with a non-TCH.
Source: Journal of NeuroInterventional Surgery - March 18, 2022 Category: Neurosurgery Authors: Chaudhry, S. A., Sadaf, H., Laleka, I., Nasir, W., Witzel, C., Bahiru, Z., Fang, Y., Ishfaq, F., Altaweel, L. R., Qureshi, A. I. Tags: Ischemic stroke Source Type: research

Health economic impact of first-pass success among patients with acute ischemic stroke treated with mechanical thrombectomy: a United States and European perspective
Conclusions FPE resulted in improved clinical outcomes, translating into lower healthcare resource use and lower estimated costs.
Source: Journal of NeuroInterventional Surgery - November 18, 2021 Category: Neurosurgery Authors: Zaidat, O. O., Ribo, M., Mattle, H. P., Saver, J. L., Bozorgchami, H., Yoo, A. J., Ehm, A., Kottenmeier, E., Cameron, H. L., Qadeer, R. A., Andersson, T. Tags: Open access, Ischemic stroke Source Type: research

Real-world outcomes associated with the use of the EmboTrap revascularization device for ischemic stroke in the United States
Conclusions This is the first study in the US to report real-world outcomes sourced by retrospective database analysis among patients with AIS undergoing MT using the EmboTrap device. Further research is needed to better understand performance of the EmboTrap device in real-world settings.
Source: Journal of NeuroInterventional Surgery - October 14, 2022 Category: Neurosurgery Authors: Brinjikji, W., Ikeme, S., Kottenmeier, E., Khaled, A., M, S., Khanna, R. Tags: Ischemic stroke Source Type: research

E-089 Rural versus metropolitan stroke activation incidence: using Viz.ai to determine disease penetrance
ConclusionCompared to a metropolitan PSC in our network, two rural PSCs had significantly higher per capita incidence of stroke activations. There was a trend toward higher per capita thrombectomy alerts as well. Given the known health disparities in rural regions of the US, these findings provide clear confirmation of the importance of stroke care protocols in rural areas, and the value of rapid identification and triage for rural communities. Our future studies will examine more detailed patient-specific factors based on geographic region.Disclosures J. Fraser: None. J. Frank: None. A. Chen: None. M. Campbell: None. L. W...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Fraser, J., Frank, J., Chen, A., Campbell, M., Wise, L., Krein, B., Silvernail, R., Dornbos, D., Pahwa, S., Lee, J. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

P-038 Demographic disparities in proximity to certified stroke care in the United States
ConclusionsDisparities in proximity to stroke care were worse in non-urban areas than in urban areas. Non-urban census tracts with greater representation of elderly, American Indian, or uninsured persons, or low median income, were substantially more distant from certified stroke care. Quantifying disparities in proximity to timely stroke care can inform ongoing efforts for infrastructure improvements that reduce inequalities in access to care.Disclosures C. Yu: None. T. Blaine: None. P. Panagos: None. A. Kansagra: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Yu, C., Blaine, T., Panagos, P., Kansagra, A. Tags: Oral poster abstracts Source Type: research

E-129 Trends in demographic and geographic disparities of stroke-related mortality in older adults in the United States from 1999 to 2020
Stroke is a leading cause of mortality and morbidity in the United States. Many risk factors are controversial, and their relative importance is not fully understood. Elucidating the association between demographic and geographic disparities and stroke-related mortality in older adults will guide policy to alleviate stroke burden. This retrospective cohort study characterizes stroke-related mortality among individuals aged 55 and older in the United States from January 1999 to December 2020 using the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database. Segmented regressio...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: McCandless, M., Powers, A., Baker, K., Strickland, A. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-152 Cone-beam CT angiogram acquisition in the angiography suite for LVO detection in acute ischemic stroke
ConclusionDTAS triage workflow with cone-beam head CT and CTA image acquisition in the angiography suite may be a next step to further optimize LVO stroke pathways by bypassing conventional CT/MR. This new workflow has the potential to further decrease door-to-needle times and thereby may improve patient outcome.Disclosures A. Kuhn: None. J. Singh: None. M. Garcia: None. S. Sarid: None. M. Gounis: 1; C; National Institutes of Health (NIH), the United States – Israel Binational Science Foundation, Anaconda, ApicBio, Arsenal Medical, Axovant, Balt, Cerenovus, Ceretrieve, CereVasc LLC, Cook Medical, Gal. 2; C; fee-per-h...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Kuhn, A., Singh, J., Garcia, M., Sarid, S., Gounis, M., Anagnostakou, V., Puri, A. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-102 Transport distances for bypass and non-bypass routing models of stroke patients in the United States
ConclusionsBypass incurs a modest distance penalty for non-LVO patients and offers a modest distance benefit for LVO patients. These differences in distance are likely insignificant to intra-hospital delays that contribute greatly to delays in EVT treatment in non-bypass transport. Based on current guidelines, bypass of the nearest stroke center for an EVT-capable center may be warranted for a majority of Americans.Disclosures C. Yu: None. P. Panagos: None. A. Kansagra: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Yu, C., Panagos, P., Kansagra, A. Tags: Electronic poster abstracts Source Type: research

O-031 Combinational therapy following elvo in a mouse model of stroke demonstrates new frontiers in neuroprotection: the mavaric trial
Stroke remains a leading cause of morbidity and mortality in the United States. Potential therapies have encountered significant barriers in attempts to translate bench to bedside research. Because of this, we have evaluated novel roles for FDA approved drugs, repurposed for treating stroke. Two such drugs, verapamil and magnesium, represent drug classes with a long history in neuroprotection trials with mixed results. Using an intra-arterial (IA) model developed in our lab, we selectively delivered our agents of interest to the stroke affected region following experimental stroke and successful recanalization. In addition...
Source: Journal of NeuroInterventional Surgery - July 23, 2017 Category: Neurosurgery Authors: Maniskas, M., Trout, A., Goodman, J., Bix, G., Fraser, J. Tags: Oral Abstracts Source Type: research

E-038 Stroke registries and publication metrics in relation to registration and industry sponsorship
ConclusionsStroke registries generate a substantial amount of publications and citations in literature. Approximately two-thirds of all publications do not reach their expected number of citations. Those registered at clinicaltrials.gov have fewer citations than their unregistered counterparts. Industry-sponsored registries have a higher impact factor, reflecting their publications in more prominent journals, but are less cited than non-sponsored ones.Disclosures W. Khawar: None. A. Monteiro: None. O. Bolanos: 5; C; Medtronic. B. Donnelly: None. K. Snyder: 2; C; Boston Scientific, Canon Medical Systems USA, Inc., MicroVent...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Khawar, W., Monteiro, A., Bolanos, O., Donnelly, B., Snyder, K., Davies, J., Levy, E., Siddiqui, A. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

O-004 A multicenter study evaluating the frequency and burden of mechanical thrombectomy on stroke centers
Conclusion This is the first study to quantify the time requirement of mechanical thrombectomy and the call burden on neurointerventional physicians at stroke centers. Over a three month period at 10 stroke centers across the United States, mechanical thrombectomy procedures occurred once every 5 days on average, although nearly 60% occurred during non-work hours. As ELVO awareness increases, thrombectomy call has important operational implications for hospitals implementing stroke call coverage. Abstract O-004 Figure 1 Disclosures T. Wilson: None. T. Kim: None. C. Frey: None. A. Spiotta: None. R. de Leacy: None. J. M...
Source: Journal of NeuroInterventional Surgery - July 23, 2017 Category: Neurosurgery Authors: Wilson, T., Kim, T., Frey, C., Spiotta, A., Leacy, R. d., Mocco, J., Albuquerque, F., Ducruet, A., Cheema, A., Arthur, A., Srinivasan, V., Kan, P., Mokin, M., Dumont, T., Rai, A., Leslie-Mazwi, T., Hirsch, J., Singh, J., Singh, J., Wolfe, S., Fargen, K. Tags: Oral Abstracts Source Type: research

E-006 Feasibility and safety of mechanical thrombectomy in stroke patients presenting with distal ACA occlusions - insights from star
ConclusionIn this multicenter study, MT for distal ACA occlusions in the A2/A3 segments seem to be feasible and associated with low complication and symptomatic hemorrhage rates. Future studies are needed to compare the functional outcome of MT versus medical management for stroke patients presenting with A2/A3 occlusions.Disclosures D. Pullmann: None. E. Almallouhi: None. S. Al Kasab: None. A. Alawieh: None. R. Chalhoub: None. R. Starke: None. R. De Leacy: None. D. Raper: None. A. Rai: None. T. Dumont: None. S. Wolfe: None. P. Jabbour: None. C. Ogilvy: None. M. Park: None. M. Levitt: None. A. Polifka: None. R. Crowley: No...
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Pullmann, D., Almallouhi, E., Al Kasab, S., Alawieh, A., Chalhoub, R., Starke, R., De Leacy, R., Raper, D., Rai, A., Dumont, T., Wolfe, S., Jabbour, P., Ogilvy, C., Park, M., Levitt, M., Polifka, A., Crowley, R., Arthur, A., Osbun, J., Crosa, R., Maier, I Tags: Electronic poster abstracts Source Type: research

E-096 COVID status is related to clot burden during thrombectomy in acute stroke patients
ConclusionOf 230 patients included in this interim analysis across 24 centers in the United States, between 02/2021 and 01/2022, 16 patients had a history of COVID. Comparing COVID-positive to non-positive, patients with COVID were younger (median 66.5 years vs 71.5 years, p 0.042), and had more intracranial clot by weight (median 101.0 mg vs 42.0 mg, p 0.047). There was a trend toward COVID positive patients to have more clot volume (median 180 cc vs 77.5 cc p 0.08), suggesting the difference was a higher clot burden instead of more density to the thrombus. These results suggest different histopathological characteristics...
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Fraser, J., Dabney, A., Vicari, J., Rivet, D., Woodward, B., Nanda, A., Fiorella, D., Baltan, S., Sohrabji, F., Pennypacker, K., Kellner, C. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

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