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Age-Dependence of Flow Homeostasis in the Left Ventricle
Conclusions: In average, blood spends 1 to 3 beats inside the LV with very low shear stress rates. The apical region is the most prone to blood stasis, particularly in mid-aged adults. The washout of blood in the normal LV is age-dependent due to physiological changes in the degree of apical penetration of the filling waves. Introduction Cardioembolic stroke is a major source of mortality and disability worldwide and blood stasis one of its major determinants (Adams et al., 1986). Left ventricular (LV) function has evolved to maximize mechanical efficiency and ensure organ perfusion at a low cost of energy and fill...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

IJERPH, Vol. 18, Pages 4406: Importance of Geospatial Heterogeneity in Chronic Disease Burden for Policy Planning in an Urban Setting Using a Case Study of Singapore
. Dickens Chronic disease burdens continue to rise in highly dense urban environments where clustering of type II diabetes mellitus, acute myocardial infarction, stroke, or any combination of these three conditions is occurring. Many individuals suffering from these conditions will require longer-term care and access to clinics which specialize in managing their illness. With Singapore as a case study, we utilized census data in an agent-modeling approach at an individual level to estimate prevalence in 2020 and found high-risk clusters with >14,000 type II diabetes mellitus cases and 2000–2500 estimated s...
Source: International Journal of Environmental Research and Public Health - April 21, 2021 Category: Environmental Health Authors: Ken Wei Tan Joel R. Koo Jue Tao Lim Alex R. Cook Borame L. Dickens Tags: Article Source Type: research

Death and cardiovascular outcomes in end-stage renal failure patients on different modalities of dialysis
CONCLUSION: The short-term incidence of death and AMI remains high in Singapore. Future studies should investigate the benefits of a tighter control of cardiovascular risk factors among ESRF patients on dialysis.PMID:35373236
Source: Ann Acad Med Singapo... - April 4, 2022 Category: General Medicine Authors: Chun Yuan Khoo Fei Gao Hui Lin Choong Wei Xian Alex Tan Riece Koniman Jiang Ming Fam Khung Keong Yeo Source Type: research

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