• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Infarct Evolution in Patients with Anterior Circulation Large-Vessel Occlusion Randomized to IV Alteplase and Endovascular Treatment versus Endovascular Treatment Alone INTERVENTIONAL
CONCLUSIONS: No statistically significant difference in infarct evolution was found in directly admitted patients who received IV alteplase and endovascular treatment within 4.5 hours of symptom onset versus patients who underwent endovascular treatment alone. Collateral status and occlusion location may be useful predictors of infarct evolution prognosis in patients eligible for IV alteplase who underwent endovascular treatment.
Source: American Journal of Neuroradiology - April 10, 2023 Category: Radiology Authors: Hoving, J. W., van Voorst, H., Kappelhof, M., Tolhuisen, M., Treurniet, K. M., LeCouffe, N. E., Rinkel, L. A., Koopman, M. S., Cavalcante, F., Konduri, P. R., van den Wijngaard, I. R., Ghariq, E., Anton Meijer, F. J., Coutinho, J. M., Marquering, H. A., R Tags: INTERVENTIONAL Source Type: research

EE568 Tenecteplase or Alteplase for Acute Ischemic Stroke? A Cost-Effectiveness Analysis
Alteplase is widely used as intravenous thrombolytic medication in acute ischemic stroke (AIS). However, tenecteplase, a genetically modified form of alteplase, has recently been shown to result in higher recanalization rates, improved functional outcome and a similar safety profile in AIS patients with large vessel occlusion (LVO) compared to alteplase. Accordingly, this study aims to evaluate the cost-effectiveness of 0.25mg/kg tenecteplase versus 0.9mg/kg alteplase for thrombolysis in AIS patients due to LVO from the Dutch healthcare payer perspective.
Source: Value in Health - December 1, 2022 Category: International Medicine & Public Health Authors: C Nguyen, MMH Lahr, DJ Van der Zee, H Van Voorst, YBWEM Roos, M Uyttenboogaart, E Buskens Source Type: research

Endovascular treatment for calcified cerebral emboli in patients with acute ischemic stroke
CONCLUSIONS: While patients with CCE had significantly lower reperfusion rates and less improvement on the NIHSS after EVT, CCE were not significantly associated with worse functional outcome or higher mortality rates. Therefore, EVT should still be considered in this specific group of patients.PMID:33799302 | DOI:10.3171/2020.9.JNS201798
Source: Journal of Neurosurgery - April 2, 2021 Category: Neurosurgery Authors: Agnetha A E Bruggeman Manon Kappelhof Nerea Arrarte Terreros Manon L Tolhuisen Praneeta R Konduri Nikki Boodt Heleen M M van Beusekom Hajo M Hund Aladdin Taha Aad van der Lugt Yvo B W E M Roos Adriaan C G M van Es Wim H van Zwam Alida A Postma Diederik W Source Type: research