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Endovascular treatment for calcified cerebral emboli in patients with acute ischemic stroke
CONCLUSIONS: While patients with CCE had significantly lower reperfusion rates and less improvement on the NIHSS after EVT, CCE were not significantly associated with worse functional outcome or higher mortality rates. Therefore, EVT should still be considered in this specific group of patients.PMID:33799302 | DOI:10.3171/2020.9.JNS201798
Source: Journal of Neurosurgery - April 2, 2021 Category: Neurosurgery Authors: Agnetha A E Bruggeman Manon Kappelhof Nerea Arrarte Terreros Manon L Tolhuisen Praneeta R Konduri Nikki Boodt Heleen M M van Beusekom Hajo M Hund Aladdin Taha Aad van der Lugt Yvo B W E M Roos Adriaan C G M van Es Wim H van Zwam Alida A Postma Diederik W Source Type: research

Prediction of long-term recurrent ischemic stroke: the added value of non-contrast CT, CT perfusion, and CT angiography
ConclusionData from CT imaging significantly improved the discriminatory performance and reclassification in predicting ischemic stroke recurrence beyond a model incorporating clinical risk factors only.
Source: Neuroradiology - March 17, 2021 Category: Radiology Source Type: research

Validation of automated Alberta Stroke Program Early CT Score (ASPECTS) software for detection of early ischemic changes on non-contrast brain CT scans
ConclusionThe performance of automated ASPECTS is comparable to expert readers and could support readers in the detection of early ischemic changes.
Source: Neuroradiology - March 17, 2021 Category: Radiology Source Type: research

MR CLEAN-LATE, a multicenter randomized clinical trial of endovascular treatment of acute ischemic stroke in The Netherlands for late arrivals: study protocol for a randomized controlled trial
Endovascular therapy (EVT) for acute ischemic stroke due to proximal occlusion of the anterior intracranial circulation, started within 6  h from symptom onset, has been proven safe and effective. Recently, EVT...
Source: Trials - February 24, 2021 Category: General Medicine Authors: F. A. V. ( Anne) Pirson, Wouter H. Hinsenveld, Robert-Jan B. Goldhoorn, Julie Staals, Inger R. de Ridder, Wim H. van Zwam, Marianne A. A. van Walderveen, Geert J. Lycklama à Nijeholt, Maarten Uyttenboogaart, Wouter J. Schonewille, Aad van der Lugt, Diede Tags: Study protocol Source Type: research

Comparison between EQ-5D-5L and PROMIS-10 to evaluate health-related quality of life 3 months after stroke: a cross-sectional multicenter study.
CONCLUSIONS: Both EQ-5D-5L and PROMIS-10 prove to be useful instruments to evaluate HRQoL in patients who are living at home 3 months after stroke. CLINICAL REHABILITATION IMPACT: It depends on the setting and underlying goal which patient-reported outcome measure is preferred to evaluate HRQoL 3 months after stroke. The PROMIS-10 should be preferred to detect differences in less affected stroke patients, whereas the EQ-5D-5L provides slightly more information in more affected stroke patients. PMID: 33448750 [PubMed - as supplied by publisher]
Source: European Journal of Physical and Rehabilitation Medicine - January 15, 2021 Category: Rehabilitation Authors: de Graaf JA, Visser-Meily JM, Schepers VP, Baars A, Kappelle LJ, Passier PE, Wermer MJ, de Wit DC, Post MW Tags: Eur J Phys Rehabil Med Source Type: research

Effect of Heparinized Flush Concentration on Safety and Efficacy During Endovascular Thrombectomy for Acute Ischemic Stroke: Results from the  MR CLEAN Registry
ConclusionEffect of heparin in flush fluids should not be ignored by clinicians or researchers as higher concentrations may be associated with higher rates of ICH. The observed variation in protocols regarding heparin concentrations between EVT centers should encourage further studies, ideally in a controlled way, resulting in recommendations on heparin use in flush fluids in future guidelines.
Source: CardioVascular and Interventional Radiology - January 3, 2021 Category: Radiology Source Type: research

Effect of intravenous thrombolysis in stroke depends on pattern of intracranial internal carotid artery calcification
The pattern of intracranial internal carotid artery calcification (ICAC) has been identified as an effect modifier of endovascular treatment in patients with acute ischemic stroke, but it is unclear whether it modifies the effect of intravenous thrombolysis. The purpose of this study was to evaluate the association between intravenous thrombolysis and 90-day clinical outcome, follow-up infarct volume, intracranial hemorrhage and recanalization across different patterns of ICAC.
Source: Atherosclerosis - November 22, 2020 Category: Cardiology Authors: Frans Kauw, Pim A. de Jong, Richard A.P. Takx, Hugo W.A.M. de Jong, L. Jaap Kappelle, Birgitta K. Velthuis, Jan W. Dankbaar, Dutch acute stroke study (DUST) investigators Source Type: research

Peripheral Artery Disease in Acute Ischemic Stroke Patients Treated With Endovascular Thrombectomy; Results From the MR CLEAN Registry
Conclusion: In the absence of an association between the presence of PAD and collateral scores or outcomes after EVT, it may be questioned whether PAD leads to RIPC in patients with acute ischemic stroke due to large vessel occlusion.
Source: Frontiers in Neurology - October 6, 2020 Category: Neurology Source Type: research

Long-Term Mortality Among ICU Patients With Stroke Compared With Other Critically Ill Patients
Conclusions: Stroke patients who need intensive care treatment have a high short-term mortality risk, but this alters favorably with increasing duration of survival time after ICU admission in patients with both ischemic stroke and intracerebral hemorrhage, especially compared with other populations of critically ill patients such as sepsis or severe community-acquired pneumonia patients.
Source: Critical Care Medicine - September 12, 2020 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Impact of different anticoagulation management strategies on outcomes in atrial fibrillation: Dutch and Belgian results from the GARFIELD-AF registry.
CONCLUSIONS: In GARFIELD-AF, despite similar characteristics, patients on anticoagulants were treated differently in NL and BE. Although the rate of major bleeding was 33% higher in NL, variations in bleeding, mortality and TE rates were not statistically significant. PMID: 32886853 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - September 3, 2020 Category: Hematology Authors: Seelig J, Hemels MEW, Xhaët O, Bongaerts MCM, de Wolf A, Groenemeijer BE, Heyse A, Hoogslag P, Voet J, Herrman JR, Vervoort G, Hermans W, Wollaert B, Boersma LVA, Hermans K, Lucassen A, Verstraete S, Adriaansen HJ, Mairesse GH, Terpstra WF, Faes D, Piete Tags: J Thromb Haemost Source Type: research

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