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The Impact of Longitudinal Data-Completeness of Electronic Health Record Data on the Prediction Performance of Clinical Risk Scores
Clin Pharmacol Ther. 2023 Apr 7. doi: 10.1002/cpt.2901. Online ahead of print.ABSTRACTThe impact of electronic health record (EHR) discontinuity, i.e., receiving care outside of a given EHR system, on EHR-based risk prediction is unknown. We aimed to assess the impact of EHR-continuity on performance of clinical risk scores. The study cohort consisted of patients aged ≥65 years with ≥1 EHR encounter in the two networks in Massachusetts (MA, 2007/1/1-2017/12/31, internal training and validation dataset), and one network in North Carolina (NC, 2007/1/1-2016/12/31, external validation dataset) that were linked with Medica...
Source: Clinical Pharmacology and Therapeutics - April 7, 2023 Category: Drugs & Pharmacology Authors: Yinzhu Jin Janick G Weberpals Shirley V Wang Rishi J Desai David Merola Kueiyu Joshua Lin Source Type: research

Original Article: Increased Stroke Severity and Mortality in Patients with SARS-CoV-2 Infection: An Analysis from the N3C Database
Studies from early in the COVID-19 pandemic showed that patients with ischemic stroke and concurrent SARS-CoV-2 infection had increased stroke severity. We aimed to test the hypothesis that this association persisted throughout the first year of the pandemic and that a similar increase in stroke severity was present in patients with hemorrhagic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - January 10, 2023 Category: Neurology Authors: Jackson A Narrett, Indika Mallawaarachchi, Chad M. Aldridge, Ethan D Assefa, Arti Patel, Johanna J Loomba, Sarah Ratcliffe, Ofer Sadan, Teshamae Monteith, Bradford B Worrall, Donald E Brown, Karen C Johnston, Andrew M Southerland, N3C consortium Source Type: research

Increased stroke severity and mortality in patients with SARS-CoV-2 infection: An analysis from the N3C database
Studies from early in the COVID-19 pandemic showed that patients with ischemic stroke and concurrent SARS-CoV-2 infection had increased stroke severity. We aimed to test the hypothesis that this association persisted throughout the first year of the pandemic and that a similar increase in stroke severity was present in patients with hemorrhagic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - January 10, 2023 Category: Neurology Authors: Jackson A Narrett, Indika Mallawaarachchi, Chad M. Aldridge, Ethan D Assefa, Arti Patel, Johanna J Loomba, Sarah Ratcliffe, Ofer Sadan, Teshamae Monteith, Bradford B Worrall, Donald E Brown, Karen C Johnston, Andrew M Southerland, N3C consortium Source Type: research

Tenecteplase use in the management of acute ischemic stroke: Literature review and clinical considerations
CONCLUSION: Current clinical evidence shows that tenecteplase is not inferior to alteplase for the treatment of ischemic stroke and suggests that tenecteplase may have a superior safety profile. Furthermore, tenecteplase also has practical advantages in terms of its administration. This can potentially lead to a decrease in medication errors and improvement in door to thrombolytic time.PMID:35020806 | DOI:10.1093/ajhp/zxac010
Source: American Journal of Health-System Pharmacy : AJHP - January 12, 2022 Category: Drugs & Pharmacology Authors: Kirubel Hailu Chad Cannon Sarah Hayes Source Type: research

Identification and Management of Ischemic Stroke in the Postanesthesia Care Unit
This report details the case of a 63-year-old male experiencing a stroke in the immediate postoperative period after total knee arthroplasty. Risk for perioperative stroke is influenced by age, sex, ethnicity, comorbidities, and some medications. The depressed neurocognitive state of patients recovering from anesthesia warrants special consideration for the identification and management of perioperative stroke.
Source: Journal of PeriAnesthesia Nursing - June 12, 2019 Category: Nursing Authors: Lisa O'Driscoll, Chad Moore, Raymond Bonds Tags: Continuing Education Source Type: research

Neuroprotection by post ‐stroke administration of an oral formulation of angiotensin‐(1–7) in ischaemic stroke
Experimental Physiology,Volume 103, Issue 6, Page 916-923, 1 June 2018.
Source: Experimental Physiology - June 1, 2018 Category: Physiology Authors: Douglas M.Bennion , Chad H.Jones , Lauren L.Donnangelo , Justin T.Graham , Jacob D.Isenberg , Alex N.Dang , VermaliRodriguez , Ruben D. M.Sinisterra , Frederico B.Sousa , Robson A. S.Santos , ColinSumners Source Type: research

Post-stroke angiotensin II type 2 receptor activation provides long-term neuroprotection in aged rats
by Douglas M. Bennion, Jacob D. Isenberg, Allison T. Harmel, Kelly DeMars, Alex N. Dang, Chad H. Jones, Megan E. Pignataro, Justin T. Graham, U. Muscha Steckelings, Jon C. Alexander, Marcelo Febo, Eric G. Krause, Annette D. de Kloet, Eduardo Candelario-Jalil, Colin Sumners Activation of the angiotensin II type 2 receptor (AT2R) by administration of Compound 21 (C21), a selective AT2R agonist, induces neuroprotection in models of ischemic stroke in young adult animals. The mechanisms of this neuroprotective action are varied, and may include direct and indirect effec ts of AT2R activation. Our objectives were to assess the...
Source: PLoS One - July 3, 2017 Category: Biomedical Science Authors: Douglas M. Bennion Source Type: research

Predictors of electrocerebral inactivity with deep hypothermia
Conclusions: Cooling to a nasopharyngeal temperature of 12.7°C or for a duration of 97 minutes achieved ECI in>95% of patients in our study population. However, patient-specific factors were poorly predictive of the temperature or cooling time required to achieve ECI, necessitating EEG monitoring for precise ECI detection.
Source: The Journal of Thoracic and Cardiovascular Surgery - April 15, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Michael L. James, Nicholas D. Andersen, Madhav Swaminathan, Barbara Phillips-Bute, Jennifer M. Hanna, Gregory R. Smigla, Michael E. Barfield, Syamal D. Bhattacharya, Judson B. Williams, Jeffrey G. Gaca, Aatif M. Husain, G. Chad Hughes Tags: Acquired Cardiovascular Disease Source Type: research